Palatable oral suspension and method

A technology of suspension and medicine, applied in the field of delicious oral suspension and its preparation

Inactive Publication Date: 2005-07-20
TOYAMA CHEM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, many traditional sweeteners are ineffective at masking specific unpleasant medicinal tastes without resorting to other taste-masking mechanisms

Method used

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  • Palatable oral suspension and method
  • Palatable oral suspension and method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Dry powders and suspensions containing des-quinolones

[0063] (3.301Kg mixed for 100mg / 5ml strength)

[0064] The dry powder containing des-quinolone was prepared by mixing-grinding-mixing process. The following ingredients were mixed in a drum mixer for 15 minutes: des-quinolone (126.9 g), sodium bisulfite (3.5 g, 200 mesh or equivalent), silicon dioxide (20 g), aspartame Vegan (200g), L-Arginine (42g), Sodium Carboxymethylcellulose (8.0g), Methylparaben (8.0g), Magnasweet 100 (18.0g), Natural Special Compound ( 30.0g), grape flavor (45.0g) and xylitol (2800.0g).

[0065] The powder was poured from the mixer and then ground through a #00 plate, hammer up, high and medium feed Fitz mill. The milled powder was mixed again for 20 minutes in the tumble mixer. Pellets were decanted from the mixer and filled to the desired fill weight into high density polyethylene 60cc bottles. Each vial is mixed with an appropriate amount of water to prepare a palatable suspension ...

Embodiment 2-5

[0067] Pediatric granules (POS) for oral suspension containing des-quinolone and L-arginine.

Embodiment 2

[0069] (3.317Kg mixed for 200mg / 5ml strength)

[0070] Preparation of dry powder

[0071] Dry granules containing des-quinolone were prepared by the mixing-grinding-mixing process described in Example 1.

[0072] Composition of 10, 100, 200 and 400MG / 5ML products,

[0073] Example No.

[0074] Each of the above formulations is mixed with an appropriate amount of water to prepare palatable suspensions at the indicated drug concentrations.

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Abstract

A drug formulation in the form of a dry powder is provided which when mixed with water forms a palatable oral suspension substantially free of bitter taste, the dry powder being formed of a drug, preferably des-quinolone, which in solution has a bitter taste, and a pH modifying agent which is preferably an alkaline material such as L-arginine, where upon mixing the dry-powder in water causes the drug to have reduced solubility or precipitate in-situ to form a palatable oral suspension essentially free of bitter taste. An oral suspension, methods for making same and a method for masking the bitter taste of drugs employing one or more pH modifying agents are also provided.

Description

[0001] This application claims priority to US Provisional Application 60 / 363,704, filed March 12, 2002, which is hereby incorporated by reference in its entirety. [0002] The present application relates to a palatable oral suspension drug formulation comprising suspended particles of a readily water-soluble drug such as des-quinolone (des-quinolone) antibacterial agent, wherein the normal bitter taste of the drug is masked, and also relates to a combination of the above drug and pH A dry powder consisting of a regulator which, when mixed with water, produces an in-situ reduction in solubility or precipitation to form a suspension of the above-mentioned powder which is substantially free of bitterness, also relates to a process for the preparation of the above-mentioned oral suspension, and also It relates to a method for masking the bitter taste of orally administered soluble bitter drugs without insoluble polymer or paraffin coating or microencapsulation process. Background o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/4709A61K47/18
CPCA61K9/145A61K31/475A61K31/4709A61K9/10A61K47/183A61K9/0095A61P31/04
Inventor I·乌拉G·J·维利
Owner TOYAMA CHEM CO LTD
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