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Use of ampelopsin in preparation of angiogenesis inhibitor drug

A technology of angiogenesis inhibition and staphylophyll, which is applied in drug combinations, antineoplastic drugs, pharmaceutical formulations, etc., and can solve problems such as reports on the application of staphylophyll that have not been seen.

Inactive Publication Date: 2005-07-06
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there have been no reports on the application of staphylophyllin in the preparation of angiogenesis inhibitor drugs

Method used

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  • Use of ampelopsin in preparation of angiogenesis inhibitor drug
  • Use of ampelopsin in preparation of angiogenesis inhibitor drug
  • Use of ampelopsin in preparation of angiogenesis inhibitor drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Take the root of the genus Snake Grape or Snake Grape in the family Vitis genus, extract and purify it by conventional extraction methods to prepare staphylophyll, and pack it into 500 mg / bottle powder ampoules or injections.

Embodiment 2

[0016] Take vine tea and extract the staphylophyllin extract conventionally without purification. After content determination, add auxiliary materials according to conventional methods, granulate, sieve, add glidants magnesium sulfate and talcum powder; process according to the conventional production process of tablets Formed into tablets, each containing 250mg of staphylococcus.

Embodiment 3

[0017] Example 3 Bovine aortic endothelial cell proliferation inhibition experiment by MTT method

[0018] 3.1.1 Isolation and culture of neonatal bovine aortic endothelial cells

[0019] References [Chai Weidong, et al. Culture of Fetal Bovine Aortic Endothelial Cells. Journal of Nanjing Medical University, 2000, 20(3): 173] method, newborn healthy dairy cows were sacrificed by carotid artery bleeding, and the aorta was isolated under aseptic conditions. 12-15cm long, put into PBS with double antibody (100U / mL each of penicillin and streptomycin). Take out the artery on the ultra-clean table, remove the fascia and fat on the outer wall of the artery, and wash it with sterile PBS phosphate buffer solution (concentration mmol / L: NaCl130, KCl2.5, NaCl2.5, NaCl2. 2 HPO 4 10, KH 2 PO 4 1.5) Rinse repeatedly 3-5 times, and cut along the middle of the petri dish. A layer of 0.25% trypsin was dripped on the inner wall of the artery, and immediately after 10-20 seconds (s), the...

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Abstract

The invention relates to the use of ampelopsin in preparation of angiogenesis inhibitor drug, wherein the suppression function of ampelopsin to propagation of blood vessel endothelial cells is reviewed, the suppression function of ampelopsin to synthesis and secretion of VEGF, bFGF by human hepatoma cells is also examined, test results show that ampelopsin has suppression function to propagation of blood vessel endothelial cells, and also suppression action to the synthesis and secretion of VEGF and bFGF.

Description

technical field [0001] The invention relates to the application of staphylococcus in the field of pharmacy, in particular to the application of staphylocin in the preparation of drugs for angiogenesis inhibitors. Background technique [0002] Grapevine is the main component of several plants of the genus Vitaceae (such as mulberry root, vine tea, etc.) that are widely distributed in southern China. Staphylin, also known as dihydromyricetin, belongs to flavonoids, and its structural formula is [0003] [0004] Chemical name: 3,5,7,3',4',5'-hexahydroxy-2,3-dihydroflavone. [0005] Wuligen is the root or whole plant of Ampelopsis cantoniensis (HooK.etArm) Planch, which is mainly produced in South China and is a traditional folk medicine. "Dictionary of Traditional Chinese Medicine" records that it has the function of anti-inflammatory and detoxification, and it is mainly used to treat osteomyelitis, acute lymphadenitis, acute parotitis, pustule, damp erysipelas, scabies, ...

Claims

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Application Information

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IPC IPC(8): A61K31/353A61P35/00
Inventor 刘德育
Owner SUN YAT SEN UNIV
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