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Preparation of polymer drug-laden coating on cardiovascular stent

A drug-loaded coating and polymer technology, applied in blood vessels, stents, medical science, etc., can solve problems such as easy to fall off and affect the treatment effect, and achieve the effect of strong adhesion

Inactive Publication Date: 2005-06-22
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the polymer coating cannot form a chemical bond with the metal surface, the coated stent is easy to fall off during disinfection, surgical delivery, and blood washing after implantation, which affects the therapeutic effect.

Method used

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  • Preparation of polymer drug-laden coating on cardiovascular stent
  • Preparation of polymer drug-laden coating on cardiovascular stent
  • Preparation of polymer drug-laden coating on cardiovascular stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The first step: the preparation of the middle layer

[0039] The surface of the 316L stainless steel stent that has undergone chemical oxidation treatment is coated with a chloroform solution of (methacryloyloxyethyl) phosphate, then dried, and then coated with a crosslinking agent, followed by photocuring treatment. Then, a cross-linking agent and a chloroform solution of aminoethylmethacrylamide are sequentially coated on it, and then photocured for use.

[0040] Step 2: Preparation of polymer drug coating

[0041] After dissolving 0.1g of poly(lactide-glycolide), wherein lactide / glycolide=80 / 20 (mol / mol), in 9.9g of chloroform, add 10mg of rapamycin and 0.1g N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide was fully dissolved, and a 316L stainless steel bracket was immersed in it, and then the bracket was dried at room temperature. This coating process was repeated twice, and then the stent was vacuum desolvated at room temperature for 48 hours to obtain a polymer dr...

Embodiment 2

[0043] The first step: the preparation of the middle layer

[0044] The surface of the 316L stainless steel stent that has undergone chemical oxidation treatment is coated with a chloroform solution of (methacryloxybutyl) phosphate, then dried, and then coated with a cross-linking agent for photocuring treatment. Afterwards, a cross-linking agent and a chloroform solution of aminopropyl methacrylamide are sequentially coated thereon, and then photocured again for use.

[0045] Step 2: Preparation of polymer drug coating

[0046] After dissolving 0.2g poly(lactide-glycolide), wherein lactide / glycolide=70 / 30 (mol / mol), in 9.8g chloroform, add 40mg rapamycin and 0.2g N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide was fully dissolved, and a 316L stainless steel bracket was immersed in it, and then the bracket was dried at room temperature. This coating process was repeated twice, and finally the stent was vacuum desolvated at room temperature for 48 hours to obtain a polymer dru...

Embodiment 3

[0048] The first step: the preparation of the middle layer

[0049] The surface of the 316L stainless steel stent that has undergone chemical oxidation treatment is coated with a chloroform solution of (methacryloyloxydecyl) phosphate, then dried, and then coated with a crosslinking agent for photocuring. Afterwards, a chloroform solution of a cross-linking agent and aminopentylmethacrylamide is coated sequentially thereon, and then photocured again.

[0050] Step 2: Preparation of polymer drug coating

[0051] With 0.3g poly(lactide-glycolide), wherein lactide / glycolide=50 / 50 (mol / mol), after it is dissolved in 9.7g chloroform, add 15mg rapamycin and 0.3g N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide, after fully dissolving, and immerse the 316L stainless steel bracket prepared with the intermediate layer in it, take out the bracket and place it at room temperature dry. This coating process was repeated twice, and then the solvent was removed under vacuum at room temperat...

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Abstract

The invention provides the preparation of polymer drug-laden coating on cardiovascular stent, which comprises carrying out surface chemical oxidation treatment to the steel stent, coating methacrylate ester cross linking agent onto the surface and performing optical solidification treatment, then immersing the stent into the mixed solution of polymer carrier and medicament, finally taking out and vacuum drying.

Description

technical field [0001] The invention belongs to the technical field of in vivo drug delivery method and medical equipment. It relates to a preparation method of a polymer drug-loaded coating for a coronary stent, especially involves preparing an intermediate layer between the metal stent surface and the polylactic acid drug-loaded coating by self-assembled monolayer technology, so as to improve the adhesion between the polylactic acid coating and the metal surface. Adhesion to avoid peeling off of the coating. Background technique [0002] Coronary heart disease is a common disease that seriously threatens human life and health. At present, coronary artery stent implantation has become a common method widely used in the treatment of coronary heart disease. However, the biggest defect of this technology is the problem of in-stent restenosis, which limits its curative effect, resulting in 20-30% of patients with postoperative in-stent restenosis. Among the many methods for pr...

Claims

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Application Information

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IPC IPC(8): A61F2/90A61L27/00A61L27/40A61L27/50
Inventor 齐民杨大智赵红刘炼刘洪泽黄莹莹张可敏邢滨杨璠
Owner DALIAN UNIV OF TECH
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