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Method for preparing 'Sanjin tablet'

A technology of gold flakes and golden cherry roots, which is applied in the field of preparation of traditional Chinese medicine preparations, can solve the problems of large loss of index active ingredients, backward production technology, large quality fluctuations, etc., and achieve good fluidity, improve product quality, and prevent pollution.

Active Publication Date: 2005-06-22
GUILIN SANJIN PHARMACEUTICALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The preparation method of Sanjin tablets has been using relatively traditional preparation technology, the production process is relatively backward, the cost is high, the loss of index active ingredients is large, and the quality fluctuates greatly

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Put the crude drugs golden cherry root, sheep mouth, smilax, golden sand vine, centella asiatica, etc. into the extraction container according to the prescription ratio 80:40:40:24:24, add water to boil, extract twice, the first time is 2 hours, the second time After 1 hour, the extracted filtrate was concentrated and concentrated into a thick paste (d=1.20 / 60°C), weighed or measured.

[0034] Granulation:

[0035] The thick paste is placed in a storage tank, spray dried, and the drying process parameters are controlled as follows:

[0036] Air inlet temperature: 200°C; outlet air temperature: 110°C; spray rate 10ml / s.

[0037] Put it into a clean and airtight container, weigh and record.

[0038] Take Sanjin tablets dry paste powder, add appropriate amount of talc powder and dry starch, put it in the hopper of a one-step granulator, use 30% ethanol as a wetting agent, and add auxiliary materials (silicon dioxide, magnesium stearate, micro Appropriate amount of crystalline ...

Embodiment 2

[0042] Put the crude drugs golden cherry root, sheep mouth, smilax, golden sand vine, centella asiatica, etc. into the extraction container according to the prescription ratio 80:40:40:24:24, add water to boil, extract twice, the first time is 2 hours, the second time After 1 hour, the extracted filtrate was concentrated and concentrated into a thick paste (d=1.20 / 60°C), weighed or measured.

[0043] Granulation:

[0044] Take proper amount of talcum powder and starch into the hopper of spray drying granulator, spray into thick paste, add appropriate amount of auxiliary materials (silicon dioxide, magnesium stearate, microcrystalline cellulose, etc.) after making granules, mix well, and granulate. Put it into a clean bucket, weigh it, and control the moisture content between 4.0% and 8.0%.

[0045] The process parameters are controlled as follows:

[0046] Inlet air temperature: 50-160°C, outlet air temperature: 40-100°C, material temperature 50-150°C, atomization pressure 0.1-0.8...

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Abstract

The invention discloses a method for preparing 'Sanjin tablet' which comprises, (1) extracting Fructus Rosae Laevigatae, sheep opening, smilax China root, Lygodium japonicum, cat's-foot with water, (2) mixing the extract with pharmaceutically acceptable carrier, spray drying and granulating, (3) tabletting, (4) dressing.

Description

Technical field: [0001] The invention relates to a preparation method of a traditional Chinese medicine preparation, in particular to a preparation method of Sanjin preparations such as Sanjin tablets, which has many advantages compared with the prior art. Background technique: [0002] Sanjin preparations such as Sanjin Tablets are the varieties included in the 2000 edition of the Chinese Pharmacopoeia. For sugar-coated tablets or film-coated tablets. The functions and indications are: clearing away heat and detoxification, removing dampness and dredging dampness, tonifying the kidney. It is used for patients with damp-heat, hot showers, short red urine, astringent leaching and pain; acute and chronic pyelonephritis, cystitis, urinary tract infections with kidney deficiency damp-heat syndrome. [0003] The preparation method of Sanjin tablets has always adopted more traditional preparation technology, the production process is relatively backward, the cost is high, the loss of i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/28A61P13/02A61P13/10A61P13/12
Inventor 邹节明
Owner GUILIN SANJIN PHARMACEUTICALS CO LTD
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