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Anticancer auxiliary medicine using 20 (S)-panaxcoside Rg3 as effertive component and its application

A technology of anticancer drugs and ginsenosides, applied in medical preparations containing active ingredients, organic active ingredients, drug delivery, etc., can solve the problems of weak anti-tumor effect and inferior effect on killing cancer cells

Inactive Publication Date: 2005-06-08
SHANDONG GREENERY NATURAL MEDICINE RES & DEV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] According to reports, Rg3 has anti-tumor, anti-angiogenesis, anti-inflammation and other effects, but about 20(S)-ginsenoside-Rg3 can enhance the efficacy of anti-cancer drugs, reduce the toxicity of anti-cancer drugs, prevent and treat leukocytes caused by radiotherapy and chemotherapy The effect of reducing and enhancing the immune function of cancer patients has not been reported; although the Chinese patent publication CN 1092204C discloses the medical use of 20(S)-ginsenoside-Rg3 in the preparation and treatment of lung cancer, melanoma and S180 sarcoma, we Research has found that although 20(S)-ginsenoside-Rg3 has certain anticancer activity, its killing effect on cancer cells is far inferior to that of chemically synthesized drugs, such as cyclophosphamide, 5-fluorouracil, cisplatin, etc.; at the same time, we also found that It has a very obvious synergistic and attenuating effect on anticancer drugs, and can also improve the immunity of cancer patients
In addition, many studies have shown that 20(R)-ginsenoside-Rg3 has significant anti-tumor activity. In 2001, China took the lead in approving the trial production of a new drug (Chinese medicine) "Shenyi Capsule" with this as an active ingredient. It was listed on the market, but its anti-tumor effect was found to be very weak in clinical application. Therefore, when the trial production became regular, the instructions were revised to "Cultivate Yuan and strengthen the foundation, nourish Qi and blood

Method used

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  • Anticancer auxiliary medicine using 20 (S)-panaxcoside Rg3 as effertive component and its application
  • Anticancer auxiliary medicine using 20 (S)-panaxcoside Rg3 as effertive component and its application

Examples

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preparation Embodiment 1

[0015] Preparation Example 1: Preparation Example of Preparation for Injection

[0016] Take by weighing 1.00g 20(S)-ginsenoside-Rg3, add the propylene glycol of 20ml n-butanol and 30ml and saponin is melted completely, the citric acid of 0.15g tetracaine hydrochloride, 0.02g is added in 40ml water for injection, make completely Dissolve, and add the above aqueous solution to the drug solution, mix well; adjust the pH value to 5.5±1.0 with borax and boric acid; add 0.1% activated carbon for needles and keep warm at 85°C for 30 minutes, filter with G3 vertical fused glass funnel, 0.22um Microporous membrane filtration; the filtrate is divided into 7ml vials, each containing 2ml (the divided injection can be directly pressed into a stopper, pressed into an aluminum cap to form an injection; or freeze-dried by a freeze dryer to make a freeze-dried powder injection .).

preparation Embodiment 2

[0017] Preparation Example 2: Tablet Preparation Example

[0018] Weigh 10.00g of 20(S)-ginsenoside-Rg3, add 90g of starch, mix well, and sieve to obtain mixed powder; ethanol aqueous solution is used as binder to make suitable soft material, granulated with 18 mesh sieve, oven at 60°C Dry for 2 hours, granulate with a 16-mesh nylon sieve, add magnesium stearate, mix well, and press into tablets, with a tablet weight of about 100mg / tablet.

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Abstract

An auxiliary anticancer medicine for increasing the curative effect of other anticancer medicines, decreasing their toxic, and preventing and treating the leukocytopenia caused by radiotherapy or chemicotherapy features that its active component is 20(s)-ginsenoside-Rg3. It is applied by injection or oral taking.

Description

technical field [0001] The invention relates to an anti-cancer auxiliary drug for enhancing the curative effect of anti-cancer drugs, reducing the toxicity of anti-cancer drugs, preventing and treating leukopenia caused by radiotherapy and chemotherapy, and belongs to the medical field of cancer treatment. Background technique [0002] Cancer is one of the three major diseases that endanger human health, and its morbidity and mortality have risen to No. 1 in some countries. Therefore, the development of anticancer drugs is one of the major issues faced by the majority of medical workers. Although many anti-cancer drugs that have been successfully developed at present have better and better therapeutic effects, their clinical application is limited because of the strong toxic and side effects of the drugs themselves. Therefore, the current anticancer drug research, on the one hand, continues to search for therapeutic drugs that kill cancer cells, and develops anticancer adju...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/704A61P35/00
Inventor 蒋王林田京伟王超云傅风华王振华
Owner SHANDONG GREENERY NATURAL MEDICINE RES & DEV
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