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Antemetic Granisetron Hydrochloride tablet and its preparation

A granisetron hydrochloride tablet, granisetron hydrochloride technology, applied in the direction of medical formula, pill delivery, drug combination, etc., to achieve the effect of convenient administration, low production cost and short production cycle

Inactive Publication Date: 2005-06-01
周宇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention aims at the defects of existing granisetron hydrochloride antiemetics and provides a new dosage form drug with convenient taking, fast action and significant effect and its preparation method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Suspend 10 mg of granisetron hydrochloride, the main drug, in 7.5 g of hydroxyethyl cellulose in an aqueous solution to form solution A. According to the formula in excipient 1, mix and dissolve 2.5 g of gelatin, 0.5 g of spices, 64.5 g of mannitol and 25 g of sucrose , to form solution B, mix solution A with solution B, add an appropriate amount of water to dilute, mix well, add to the mold to freeze at low temperature, put it in a freeze dryer to vacuum, sublimate the ice until the material is completely dry, press seal and pack .

[0038] The total weight of the five auxiliary materials is 100g, and 1000 tablets are made, and each auxiliary material is 100mg. The main drug granisetron hydrochloride is 10 μg, that is, the weight of each orally disintegrating tablet is 100.01 mg.

Embodiment 2

[0040] 20mg granisetron hydrochloride, 10g gelatin, 1g spices, 1g hydroxyethyl cellulose, 15g mannitol and 73g sucrose replace the raw material consumption in embodiment 1, method is the same as embodiment 1, the total weight of five kinds of auxiliary materials is 100g, makes 1000 tablets, each tablet has excipients 100mg, main drug granisetron hydrochloride 20μg. That is, each tablet weighs 100.02 mg. Each tablet contains 20 μg of granisetron hydrochloride.

Embodiment 3

[0042] Glucose 30g, compressible sorbitol 10g, mannitol 20g, sucrose 20g, sodium bicarbonate 10g, citric acid 9.9g, saccharin sodium 0.05g, aspartame 0.05g, a total of eight kinds of excipients 100g mixed with granisetron hydrochloride 30mg Uniform, add wetting agent to make soft material, sieve, dry, granulate, add lubricant and compress into tablets to make 1000 tablets, each weighing 100.03 mg, including 30 μg of granisetron hydrochloride and 100 mg of excipients.

[0043] The orally disintegrating tablets of granisetron hydrochloride produced in the above three examples are 3.0mg, 10mg, and 20mg in three specifications, and other specifications can also be produced. The weight of each tablet is variable, and the main drug content is 0.1-24mg / tablet. Easy to take.

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Abstract

The orally disintegrated granisetron tablet as antiemetic is prepared with granisetron hydrochloride as main medicine component, hydroxyethyl cellulose and other medicinal supplementary material. After being taken, the antiemetic may be disintegrated fast in orally and swallowed into digestive tract without need water to produce excellent effect of preventing and treating nausean and vomiting caused by chemotherapy, radiotherapy and surgical operation. The present invention has low production cost.

Description

technical field [0001] The invention relates to an antiemetic granisetron hydrochloride tablet and a preparation method thereof. Background technique [0002] Some chemotherapy drugs can cause nausea and vomiting when used. Severe nausea can make patients daunted by the subsequent chemotherapy, and even have the idea of ​​unwillingness or giving up further chemotherapy, making chemotherapy unsustainable. However, commonly used antiemetic drugs are not effective against the vomiting caused by chemotherapy. [0003] Granisetron hydrochloride is a potent and highly selective 5-HT3 receptor antagonist in peripheral neurons and central nervous system. Chemotherapy, radiotherapy, surgery and other factors can cause enterochromaffin cells to release 5-HT, and 5-HT can activate the 5-HT3 receptors in the central or vagus nerves to trigger vomiting. Granisetron hydrochloride can selectively block the triggering of this vomiting reflex without the side eff...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/439A61P1/08
Inventor 周宇
Owner 周宇
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