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Ethylene equol molecular engram solid phase extracting small pole and its its prepn process

A technology of solid-phase extraction cartridges and diethylstilbestrol, which is applied in the field of analytical chemistry and can solve the problem that solid-phase extraction cartridges cannot separate DES and fat

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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

but C 18 SPE cartridges do not separate DES and fat well

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] (1). Preparation of diethylstilbestrol (DES) imprinted molecular polymer:

[0017] Reaction raw material list

[0018] Molecular weight Reaction amount

[0019] Reagent

[0020] (g / mol) Molar weight (mmol) Mass (g) Actual amount

[0021] Diethylstilbestrol

[0022] 268.4 0.50 0.134 270mg

[0023] DES

[0024] Methacrylic acid MAA 68.01 2.0 0.136 0.136ml

[0025] Ethylene glycol dimethacrylate

[0026] 198.22 10.0 1.687 2.0ml

[0027] EDMA

[0028] Azobisisobutyronitrile AIBN 164.21 0.12 19.7 19.7g

[0029] Acetonitrile 6ml

[0030] To

[0031] Chloroform 6ml

[0032] hole

[0033] Diethyl ether 6ml

[0034] agent

[0035] 6ml of the above three liquids

[0036] Add the reaction reagents Diethylstilbestrol (MES), methacrylic acid (MAA), ethylene glycol dimethacrylate (EDMA), azobisisobutyroni...

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Abstract

The invention discloses a molecular impriting solid-phase extraction small column capable of high-selectively purifying and enriching diethyl stiboestrol (DES) from sample solution for determining residual amount of artificially-synthetic estrin diethyl stiboestrol (DES) in animal food and its preparation method. Said invention uses diethyl stiboestrol as molecular template to prepare molecular imprinting polymer, it is a cross-linked polymer with fixed hole size and form and definite arranged function group, and has the 'memory' function for steresotructure of diethyl stiboestrol template molecule, so that said material can be fileld into polypropylene small column so as to can obtain the diethyl stiboestrol molecular imprinting solid-phase extraction small column. As compared with general solvent extraction method and C18 solid-phase extraction method said invented imprinting column is more simple, quick and higher in efficiency.

Description

technical field [0001] The invention relates to the field of analytical chemistry, in particular to the highly selective purification and enrichment of diethylstilbestrol molecularly imprinted solid-phase extraction small columns for measuring the residual amount of artificial estrogen diethylstilbestrol (DES) in animal foods and the Preparation. Background technique [0002] Diethylstilbestrol (DES) is a synthetic estrogen with a phenolic hydroxyl structure, and many countries such as Europe and the United States prohibit its use in animal feed. Due to the abuse of diethylstilbestrol, the detection of diethylstilbestrol residues in animal foods has attracted great attention at home and abroad. According to the prescribed amount, the residual status of diethylstilbestrol in animal tissues and body fluids is: the concentration in muscle and fat is very low, usually <0.5μg / kg, the concentration in liver is <2μg / kg, and the concentration in excre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/08G01N30/84
Inventor 陈波马金余刘程
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