Soft capsule of decoction of four ingredients possessing effect of enriching blood and regulating menstruation and preparation method

Abstract

A Chinese medicine in the form of softgel for nourishing blood, promoting blood circulation and treating menoxenia is composed of the core prepared from rehmannia root, white peony root, Chinese angelica root and Chuan-xiong rhizome and the softgel wall prepared from gelatin, plasticizer, water, light shielding agent and nipagin. Its preparing process is also disclosed.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and relates to a new preparation of Chinese patent medicine, more specifically, to a Siwutangfang soft capsule made of four Chinese herbal extracts of rehmannia glutinosa, white peony root, angelica, and chuanxiong rhizoma as raw materials and its preparation method. Background technique [0002] Siwu Decoction comes from the "Taiping Huimin Heji Bureau Prescription" in the Song Dynasty, and is composed of four traditional Chinese medicines: rehmannia glutinosa, white peony root, angelica, and chuanxiong. It has the functions of nourishing blood, promoting blood circulation, and regulating menstruation. It is used for all symptoms such as stagnation of nutrient blood deficiency, women's irregular menstruation, pain in the navel and abdomen, metrorrhagia, hard lumps of blood, pale tongue with white fur, etc. Siwu Decoction is a common prescription for nourishing blood and a basic prescription fo...

AI Technical Summary

Problems solved by technology

But the mixture has the following disadvantages: (1) poor stability, which affects the quality of medicines: one of the main effective parts of Angelica and Rhizoma Chuanxiong volatile oil is extremely unstable in aqueous solution

Ligustilide has the highest content (30-80%) in the volatile oil of Angelica and Chuanxiong, and the most active ingredient, ligustilide, is easily decomposed by isomerization reaction at room temperature, especially in aqueous solution, ligustilide The pharmacological effects of the decomposed volatile oil of Rhizoma Chuanxiong significantly decreased or even disappeared [Shi Lifu, et al. Chinese Journal of Pharmacology and Toxicology, 1995; 9(2): 157], thereby affecting the quality of the drug; (2) long-term storage is easy to produce precipitation; ( 3) It is inconvenient to carry and transport; (4) The volatile oil of angelica and chuanxiong has a special odor and is irritating to the gastrointestinal tract, which is difficult for patients to accept

Therefore, it is unreasonable to make Siwu Decoction into a mixture dosage form

And Siwu Decoction Granules is 10g at a time, and the dosage is large; the content of active substances is low, and the content of auxiliary materials is more than 80%; it needs to be taken with water, which is inconvenient to take

At present, there is no report on the development of Siwutangfang soft capsule formulations