Oral disintegrants of nimodipine and their preparation

Abstract

An oral disintegrating tablet of nimodipine is prepared from nimodipine, carrier, adsorbent, disintegrant, filler, soluble polybasic alcohol, and other auxiliaries.

Description

technical field [0001] The invention relates to a dosage form of nimodipine, in particular to an orally disintegrating tablet of nimodipine and a preparation method thereof. technical background [0002] Nimodipine is an insoluble polymorphic drug with a large first-pass effect, low bioavailability in vivo, and uncertain curative effect. In recent years, the crystal form phenomenon of drugs has also attracted great attention. With the deepening of research, it is found that the crystal form of a drug has a great relationship with the curative effect, dissolution rate, bioavailability, and stability of the drug. The research on the polymorphic form of the drug and the selection of the appropriate drug crystal form are beneficial to the transformation of the drug. In order to improve clinical efficacy and reduce toxic and side effects. Using solid dispersion technology to highly disperse drugs with appropriate crystal forms into water-soluble polymer ...

AI Technical Summary

Problems solved by technology

However, these dosage forms have several problems when taking

For example, the crystal form of the active ingredient of the drug used is not appropriate, and the drug has not been dispersed in a solid, resulting in poor dissolution and low bioavailability; the elderly and young children with weak swallowing power or patients in special environments (such as lack of water) are taking When taking tablets and capsules, it is difficult to swallow, and there may even be reluctance to take due to blockage of the throat and esophagus and reluctance to take due to blockage of the esophagus