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Silybum marianum dripping pill and its preparing method

A silymarin and silymarin-containing technology, which is applied in pill delivery, digestive system, metabolic diseases, etc., can solve the problems of low dissolution rate, slow dissolution rate of silymarin tablets, and low bioavailability, so as to achieve high drug efficacy and increase bioavailability , high bioavailability

Inactive Publication Date: 2005-01-12
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can solve the problems of slow dissolution rate, low dissolution rate and low bioavailability of silymarin tablets. Using solid dispersion technology, silymarin can be made into medicines with high bioavailability, good stability, good absorption performance, and drug effect. Dropping pills that are rapid, non-irritating to the gastrointestinal tract, and have low toxic and side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Take 95% of polyethylene glycol 6000 and heat and melt at 90°C, add 5% of 80-mesh silymarin, stir and mix, pour it into a self-made dropping pill device kept at 90°C, let it stand for 10 minutes, and at 90°C, use Drop into simethicone oil: liquid paraffin (80:60, V / V) at a speed of 10 drops / minute, and the weight of each drop is 100 mg. After condensing into pellets, recover the condensate and absorb the condensate on the surface of the pellets Drying, inspection, packaging, to get the finished product.

[0016] Implementation effect: This process can produce smooth, roundness, moderate hardness, and weight difference that meets the requirements of the Pharmacopoeia. The silymarin dripping pills of the present invention are measured by an intelligent dissolution tester and an ultraviolet spectrophotometer, and the average cumulative dissolution amount of the silymarin within 60 minutes is 68.94%, which can improve the dissolution of the silymarin.

Embodiment 2

[0018] Take 60% of polyethylene glycol 6000 and 15% of polyethylene glycol 4000 and heat and melt at 80°C, add 25% of 80-mesh silymarin, stir and mix well, pour it into a self-made dropping pill device kept at 80°C, and place it for 10 minutes , in the state of 80°C, drip into the camellia oil at a rate of 20 drops / minute, and the weight of each drop is 50mg. After being condensed into pills, the condensate is recovered, and the condensate on the surface of the pills is adsorbed and dried, inspected, packaged, to get the finished product.

[0019] Implementation effect: This process can produce smooth, roundness, moderate hardness, and weight difference that meets the requirements of the Pharmacopoeia. The silymarin dripping pills of the present invention are measured by an intelligent dissolution tester and an ultraviolet spectrophotometer, and the average cumulative dissolution amount of the silymarin within 60 minutes is 75.22%. Can improve the dissolution of silymarin.

Embodiment 3

[0021] Get 25% of the amount of polyethylene glycol 6000, 25% of the amount of sodium stearate, 25% of the amount of glyceryl monostearate, 5% of the amount of poloxamer at 60 ℃ heating and melting, add 20% of the amount of 80 The target silymarin is mixed evenly, poured into a self-made dropping pill device kept at 60°C, placed for 10 minutes, and dropped into vegetable oil at a rate of 50 drops / min with a weight of 10 mg per drop at 60°C, and waited to be condensed into After the pills, the condensate is recovered, and the condensate on the surface of the pills is adsorbed and dried, inspected, packaged, and the finished product is obtained.

[0022] Implementation effect: This process can be used to produce dripping pills that are slightly rough, slightly poor in roundness, moderate in hardness, and have weight differences that meet the requirements of the Pharmacopoeia. The silymarin dripping pills of the present invention are measured by an intelligent dissolution tester ...

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PUM

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Abstract

A dripping pill of silybin for treating hepatitides, early hepatocirrhosis and hyperlipemia is prepared from silybin and matrix chosen from polyglycol 6000, polyglycol 4000, sodium stearate, poloxamer, and monoglyceride stearate. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to the technical field of medicine. In particular, the invention relates to a hepatoprotective medicine, silymarin dripping pills capable of treating acute hepatitis, chronic hepatitis, persistent hepatitis, early liver cirrhosis and hyperlipidemia and a preparation method thereof. Background technique [0002] Hepatitis and various liver injuries are common and frequently-occurring diseases, which seriously endanger people's health. my country is a "hepatitis big country", and there are 20 million chronic hepatitis B patients. The commonly used liver protection drugs in clinical practice mainly include inosine, coenzyme Q10, milk thistle, cilibinamine, Liganlong, Yiganling, and compound Yiganling, oleanolic acid, etc., most of which are various silymarin preparations or compound preparations containing silymarin. [0003] Silymarin is an insoluble water-soluble flavonoid compound extracted and refined from the dried fruit of mil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/357A61P1/16A61P3/06
Inventor 贾伟李绍顺邱明丰沈琦孙霞
Owner SHANGHAI JIAO TONG UNIV
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