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Method for preparing hydroxyapatite biodegradable aliphatic polyester composite material

A technology of hydroxyapatite and aliphatic polyester is applied in the field of preparation of hydroxyapatite biodegradable aliphatic polyester composite material, which can solve the problem of limiting the application range of composite materials, high toxicity of isocyanate and less covalent bond connection and other problems, to achieve the effect of high use value, uniform and stable dispersion, and good biocompatibility

Active Publication Date: 2004-11-10
CHANGCHUN SINOBIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method is far from meeting the requirements of practical applications. The toxicity of isocyanate is very high. Its addition limits the application range of composite materials and is not environmentally friendly. Moreover, the hydroxyapatite particles actually obtained in the composite materials obtained by this method -Isocyanate-Polymer molecular chains with little covalent linkage

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Preparation of modified hydroxyapatite nanoparticles grafted with lactic acid on the surface. In three reaction flasks, disperse 15g of hydroxyapatite (HA) nanoparticles (about 20-50nm in diameter) in 80ml of tetrahydrofuran solvent, and slowly add 7.5ml, 15ml, and 30ml of lactic acid, after the lactic acid is completely added, stir and react at 60°C for 3 hours, then add 200ml of toluene and continue the reaction for 10 hours under azeotropic dehydration conditions. The product was repeatedly washed with tetrahydrofuran and ethanol five times to remove unloaded lactic acid, and dried in vacuum at 40° C. for 48 hours to obtain modified hydroxyapatite nanoparticles loaded with lactic acid on the surface. Infrared spectroscopy can verify the chemical connection between lactic acid and nanoparticles, and the loading amount of lactic acid on nanoparticles obtained by thermogravimetric method is shown in Table 1.

[0027]

Embodiment 2

[0029] In embodiment 1, replace tetrahydrofuran solvent with dioxane, test procedure and method are identical with embodiment 1. The results of the content of lactic acid grafted on the surface of hydroxyapatite are shown in Table 2.

[0030]

Embodiment 3

[0032] In embodiment 1, replace toluene dehydrating agent and dispersant with xylene, test procedure and method are identical with embodiment 1. The results of the content of lactic acid grafted on the surface of hydroxyapatite are shown in Table 3.

[0033]

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Abstract

The invention provides a process for preparing a novel nanometer / micrometer inorganic- biological degradable polyester composite material comprising, subjecting hydroxyapatite nanometer / micrometer particles and lactic acid to dewatering polycondensation reaction in organic solvent under the condition of heating and stirring, further reacting under toluene azeotropic dewatering condition, the dewatering polycondensation reaction can also be conducted to hydroxyapatite and lactic acid without the presence of solvent, grafting the hydroxyl of the particle surface of the hydroxyapatite to obtain the chemical constitution of lactic acid ester or low polylactic acid ester - hydroxyapatite, under the condition of waterless and oxygen free, using stannous octoate as initiating agent to trigger epsi-caprolactone, lactide, glycolide or cyclic ester monomer, and ring-opening polymerizing to obtain the homopolymer of epsi-caprolactone, lactide or glycolide biodegradable polyester and the nanometer / micrometer composite material of their dyadic and ternary copolymer.

Description

technical field [0001] The invention relates to a preparation method of a hydroxyapatite biodegradable aliphatic polyester composite material. Background technique [0002] Aliphatic polyesters, such as polylactide (PLA), polyε-caprolactone (PCL), and polyglycolide (PGA), are currently a class of fully biodegradable materials that are widely used. Aliphatic polyester has low immunity and good biodegradability, biocompatibility and mechanical strength, so it is widely used in biomedical and medical fields, such as: fracture fixation materials, surgical sutures, tissue engineering scaffold materials, drugs Sustained-release carrier materials, etc. [0003] Hydroxyapatite is a good degradable bone substitute material, and almost no adverse reactions occur in the human body. There have been a large number of literature reports that osteoblasts are more likely to grow on bone-like hydroxyapatite. The osseointegration ability of pure polylactic acid is low. A large number of stu...

Claims

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Application Information

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IPC IPC(8): C08K3/32C08L67/04
Inventor 陈学思邱学宇洪重奎景遐斌边新超杨立新徐效义
Owner CHANGCHUN SINOBIOMATERIALS
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