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Cyclodextrin cross-linking polymeric microsphere capable of absorbing bilirubin and its preparation and application

A cross-linked polymer and cyclodextrin technology, applied in other chemical processes, chemical instruments and methods, etc., can solve the problems of cumbersome preparation process of adsorption materials, poor selectivity and blood compatibility, and unsatisfactory removal effect, etc., to achieve Good clinical application potential, simple preparation process, high removal efficiency and selectivity

Inactive Publication Date: 2004-11-03
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

With the development of synthetic chemistry and polymer chemistry, hemoperfusion has gradually become a powerful means to remove bilirubin; now the materials used in this area mainly include activated carbon, resin, and polymers with dyes as affinity groups; Activated carbon is used as the adsorption material, the particles are easy to scatter and cause blood clogging, and the albumin-collodion activated carbon microcapsules are made into albumin-collodion activated carbon microcapsules, which have the disadvantages of complicated manufacturing industry and poor adsorption selectivity; general resin polymers and dyes as affinity There are also problems such as poor selectivity and blood compatibility, and contamination of blood in the polymer of the group.
Immunoadsorption materials for the treatment of hyperbilirubinemia (Chinese Patent Application No. 01128196.0) have disadvantages such as cumbersome preparation process, high cost, poor blood capacity, unsatisfactory removal effect, slow adsorption speed, and poor specificity.

Method used

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  • Cyclodextrin cross-linking polymeric microsphere capable of absorbing bilirubin and its preparation and application
  • Cyclodextrin cross-linking polymeric microsphere capable of absorbing bilirubin and its preparation and application
  • Cyclodextrin cross-linking polymeric microsphere capable of absorbing bilirubin and its preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A bilirubin adsorbent microsphere, which uses a cyclodextrin compound as a monomer and 1,6-hexamethylene diisocyanate as a crosslinking agent;

[0019] The synthetic method of the granular cross-linked polymer that adsorbs bilirubin is as follows:

[0020] 1) Weigh a certain amount (0.3510g) of cyclodextrin and dissolve it in 20mL of dry dimethyl sulfoxide, and sonicate it at 20°C for 30 minutes to completely dissolve it;

[0021] 2) Take a certain amount (1.2ml or 1.8ml) of 1,6-hexamethylene diisocyanate and pour it into the DMSO solution of step 1) cyclodextrin, and continue to sonicate for 5 minutes to obtain a uniform solution;

[0022] 3) Pour the homogeneous mixture in step 2) into a 50mL round-bottomed flask that has been purged with nitrogen for 5 minutes in advance, put in a magnet, seal the flask, and stir and react for 6 hours at 45°C;

[0023] 4) The polymer particles obtained in step 3) were thoroughly rinsed with acetone, hot water, and hot ethanol in seq...

Embodiment 2

[0031] A bilirubin adsorbent microsphere, which uses cyclodextrin compounds as monomers and diphenylmethane-4,4'-diisocyanate as crosslinking agent;

[0032] The synthetic method of the granular cross-linked polymer that adsorbs bilirubin is as follows:

[0033] 1) Weigh a certain amount of cyclodextrin and dissolve it in 20mL of dry dimethyl sulfoxide, and sonicate it at 50°C for 10 minutes to completely dissolve it;

[0034] 2) Measure a certain amount of diphenylmethane-4,4'-diisocyanate and pour it into the DMSO solution of step 1) cyclodextrin, and continue ultrasonication for 15 minutes to obtain a uniform solution;

[0035] 3) Pour the homogeneous mixture in step 2) into a 50mL round-bottomed flask that has been purged with nitrogen for 10 minutes in advance, put in a magnet, seal the flask, and stir and react for 1 hour at 80°C;

[0036] 4) The polymer particles obtained in step 3) were thoroughly rinsed with acetone, hot water, and hot ethanol in sequence to remove u...

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Abstract

The present invention relates to the removal of bilirubin from blood, and is especially cyclodextrin crossed polymer microsphere for adsorbing bilirubin and its preparation and application. The microsphere is prepared with diisocyanate as crosslinking agent and through condensation with cyclodextrin monomer. The polymer microsphere of the present invention has low cost and results in simplified experiment process, and the efficient removal of bilirubin with the polymer microsphere shows that the said material has excellent clinical application latent.

Description

technical field [0001] The invention relates to the removal of bilirubin in blood, in particular to cyclodextrin cross-linked polymer microspheres for absorbing bilirubin and its preparation and application. Background technique [0002] The removal of bilirubin in the blood has always been one of the focuses of the medical community. At present, scientists have adopted many methods to remove excess bilirubin in the blood, such as phototherapy, hemodialysis, and hemoperfusion. (hemoperfusion) or a combination of multiple technologies. With the development of synthetic chemistry and polymer chemistry, hemoperfusion has gradually become a powerful means to remove bilirubin; now the materials used in this area mainly include activated carbon, resin, and polymers with dyes as affinity groups; Activated carbon is used as the adsorption material, the particles are easy to scatter and cause blood clogging, and the albumin-collodion activated carbon microcapsules are made into albu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26
Inventor 邹汉法郑朝俊孔亮黄晓冬
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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