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Dispersion tablet of Tamoxifen(Nolvedox) of cedrat acid as well as preparationmethod and usage

A technology of tamoxifen and citric acid, which is applied in the field of medicine, can solve problems such as exhaustion, and achieve the effects of less gastrointestinal irritation, simple preparation process, and stable quality for long-term storage

Inactive Publication Date: 2004-10-27
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this complex does not stimulate RNA and protein synthesis, but depletes estrogen receptors in the cytoplasm, thereby antagonizing the effects of estrogen

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Tamoxifen Citrate 10%

[0014] Crospovidone 20%

[0015] Lactose 20%

[0016] Microcrystalline Cellulose 50%

[0017] Talc 0.5%

[0018] 90% ethanol appropriate amount

[0019] The above-mentioned raw and auxiliary materials are respectively passed through a 100-mesh sieve, granulated by wet method, and pressed into dispersible tablets.

Embodiment 2

[0021] Tamoxifen Citrate 20%

[0022] Sodium Starch Carboxymethyl 10%

[0023] Starch 40%

[0024] Microcrystalline Cellulose 30%

[0025] Magnesium Stearate 0.5%

[0026] 90% ethanol appropriate amount

[0027] The above-mentioned raw and auxiliary materials are respectively passed through a 100-mesh sieve, granulated by wet method, and pressed into dispersible tablets.

Embodiment 3

[0029] Tamoxifen Citrate 10%

[0030] Low Substituted Hydroxypropyl Cellulose 30%

[0031] Mannitol 30%

[0032] Dextrin 30%

[0033] Magnesium Lauryl Sulfate 0.5%

[0034] 90% ethanol appropriate amount

[0035] The above-mentioned raw and auxiliary materials are respectively passed through a 100-mesh sieve, granulated by wet method, and pressed into dispersible tablets.

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PUM

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Abstract

A dispersing tablet of tamoxifen citrate is prepared from tamoxifen citrate, disintegrant, filler, lubricant and alcohol through sieving by 100 meshes, proportionally mixing, wet granulating, drying, sieving by 18-24 meshes, adding lubricant, and tabletting. It can be used for treating mastadenoma, melanocarcinoma, etc.

Description

Technical field: [0001] The invention relates to the technical field of medicine, specifically tamoxifen citrate dispersible tablet and its preparation method and application. Background technique: [0002] Tamoxifen citrate, the chemical name is (Z)-N,N-dimethyl-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-ethylamine Citrate, synthesized in 1964. Tamoxifen is a steroid that is structurally similar to estrogen. Pharmacological research data show that tamoxifen can compete with estradiol for estrogen receptors in the cytoplasm, form stable complexes with estrogen receptors, and transport them in the nucleus. However, this complex does not stimulate RNA and protein synthesis, but depletes estrogen receptors in the cytoplasm, thereby antagonizing the effects of estrogen. The anti-breast cancer effect of this product mainly relies on its anti-estrogen effect to stop the growth of estrogen-dependent cancer cells. Its curative effect is directly proportional to the estrogen receptor ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/138A61P35/00
Inventor 潘卫三姜华威
Owner SHENYANG PHARMA UNIVERSITY
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