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Poly lactic acid composition film and its preparing method and use

A technology of polylactic acid and composition, applied in the field of polylactic acid composition film and its preparation and use, can solve the problems of lack of extensibility, insignificant effect, inability to repair cleft palate, etc., to reduce risks, shorten anesthesia time, shorten the The effect of surgery time

Inactive Publication Date: 2004-09-29
成都迪康中科生物医学材料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, there are related studies on polyhydroxybutyrate film (West China Journal of Stomatology, 2000, 18 (4) period) and collagen film (Journal of Oral and Maxillofacial Surgery, 2001, 11 (2)). Among them, collagen film is commonly used Although it can be absorbed by the human body, the retention time is too short, and it will be absorbed after 2 to 3 weeks, and the effect is not obvious
[0003] Polylactic acid and its copolymers are medical materials with good biocompatibility and can be completely absorbed by the human body. However, since the glass transition temperature of polylactic acid is higher than room temperature (Tg: 55-60°C), the polylactic acid film is brittle at room temperature. Not extensible and cannot be used directly for cleft palate repair

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Poly DL-lactic acid 85% and acetyl tributyl citrate 15% were mixed in a kneader for 15 minutes, and then formed with a Haake Rheomix Model 202 single-screw extruder equipped with a monofilament nozzle with a diameter of 0.25cm . The extrusion conditions are as follows: the temperature of the first heating zone is 145°C, the temperature of the second heating zone is 155°C, the temperature of the third heating zone is 135°C, the rotation speed of the screw is 35 rpm, and water is used as the cooling liquid for the molten filament. Then cut into granules with a length of 0.25 cm with a granulator. The particles were vacuum dried at 50°C for 4 hours before use.

[0024] The blend pellets were extruded into films using a Haake Rheomix Model 202 single-screw extruder. The extruder is equipped with a sheet nozzle with a width of 10cm and a die gap of 0.2cm. The temperature of the first heating zone is 145°C, the temperature of the second heating zone is 155°C, the temperatur...

Embodiment 2～13

[0025] Embodiment 2~13, method is the same as implementation 1, concrete composition following table.

Embodiment 14

[0027] Add the mixture granules of Example 1 to 5% bone morphogen protein, and form a film after mixing.

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Abstract

The polylactic acid film contains polylactic acid 85-98 wt% and medical plasticizer 2-15 wt%, the polylactic acid may be poly L-lactic acid, poly DL-lactic acid, lactic acid-glycolic acid copolymer or the copolymer of poly L-lactic acid and poly DL-lactic acid with molecular weight of 20-1500 KDa, and the medical plasticizer is tributyl citrate, tributyl acetylcitrate, polyethylene glycol or lactic acid oligomer. The polylactic acid composition of the present invention has excellent flexibility, may be used in introducing the growth of hard and soft tissues in repairing cleft palate or as regenerating film, and introducing the regeneration of bone tissue.

Description

technical field [0001] The invention relates to a composite film of polylactic acid and a preparation method thereof, as well as its application in cleft palate repair. To prevent adhesion, the more important purpose is to guide tissue regeneration. Background technique [0002] Biofilm and its technology are the hotspots of current research and application. Among them, biofilm-guided growth or regeneration of tissues (including soft and hard tissues) is an important research and application development content. For example, in traditional cleft palate reconstruction surgery, due to the stripping and exposure of the bone tissue wound surface, the exposed bone surface affects the growth of the maxilla, resulting in abnormal development of the maxilla, and finally forms a developmental deformity of the jaw. One of the means to solve this difficult problem is to study and apply some biofilm materials as a protective film, which is placed on the exposed...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/60C08J5/18C08L67/00
Inventor 魏世成李万山郑谦宁秋罗恩余兰王德祥杨德娟熊成东
Owner 成都迪康中科生物医学材料有限公司
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