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Method for preparing Diaoxinxuekang micro pill

A technology of Xinxuekang and Diao, applied in the field of preparation of Diao Xinxuekang pellets, can solve the problems of low bioavailability and the like

Inactive Publication Date: 2004-09-29
成都尚科药业有限公司
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AI Technical Summary

Problems solved by technology

[0002] Di'ao Xinxuekang is a raw material medicine extracted from the rhizomes of Dioscoreaceae yellow yam and Dioscorea chinensis. It is recorded in the 2000 edition of "Chinese Pharmacopoeia", page 441. Now it is generally processed into ordinary capsules for use, and its bioavailability is low. Clinical need a kind of efficient, convenient dosage form, Here it is the problem that the present invention solves

Method used

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Embodiment Construction

[0004] 1. Taking Di'ao Xinxuekang as the raw material drug, adding auxiliary materials such as microcrystalline cellulose, methyl cellulose, polyethylene glycol, etc., through the following preparation process: mixing the drug and auxiliary material powder evenly, adding a binder to make a soft material, and sieving Granulate, roll in a coating pan to form a pellet not less than 0.5 mm and not more than 2.5 mm, and meet the relevant requirements for "micro-pills" in an appendix of the 2000 edition of "Chinese Pharmacopoeia".

[0005] 2. Taking Di'ao Xinxuekang as the raw material drug, adding auxiliary materials such as polyethylene glycol, etc., through the following preparation process: melting the drug and auxiliary material powders by melting method, mixing them, and dripping them into the cooling liquid through the drip nozzle to prepare no less than 0.5mm. Pills not larger than 2.5 mm, and comply with the relevant requirements for "micro-pills" in an appendix of the 2000 ...

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Abstract

The Diaoxinxuekang micro pill is prepared with the medicine material extracted from yellow Chinese yam as a kind of yam plant and tuber of dioscorea nipponica and supplementary material, and through one of the following four processes: mixing the medicine material and the supplementary material, adding adhesive to prepare soft material, sieving, pelletizing and coating to form micro pill; mixing the medicine material and the supplementary material in a fluidizing bed while blowing air flow and spraying adhesive to obtain granule and drying the granule in a boiling bed; melting medicine material and supplementary material powder, mixing and dropping into cooling liquid; and mixing the medicine material, supplementary material and adhesive, extruding the mixture into strips, cutting the strips and form spherical pills. The pills are of the size of 0.5-2.5 mm.

Description

technical field [0001] pharmaceutical technology Background technique [0002] Di'ao Xinxuekang is a raw material medicine extracted from the rhizomes of Dioscoreaceae yellow yam and Dioscorea chinensis. It is recorded in the 2000 edition of "Chinese Pharmacopoeia", page 441. Now it is generally processed into ordinary capsules for use, and its bioavailability is low. A highly efficient and convenient dosage form is needed clinically, which is the problem solved by the present invention. Contents of the invention [0003] Take Diao Xinxuekang, which is recorded on page 441 of the 2000 edition of "Chinese Pharmacopoeia", extracted from the rhizomes of Dioscoreaceae yellow yam and Dioscorea punctatus, as the raw material drug, and add excipients such as starch, methyl cellulose, ethyl cellulose , polyethylene glycol, etc., through one of the following preparation processes: 1. Mix the medicine and auxiliary material powder evenly, add a binder to make a soft material, sieve...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61P9/10
Inventor 牛锐
Owner 成都尚科药业有限公司
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