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Medicine composition for regulating blood fat

A technology for regulating blood lipids and compositions, applied in the field of medicine, can solve the problems of easy rebound of blood lipids and the like, and achieve the effect of regulating blood lipids with strong biological activity

Inactive Publication Date: 2009-11-25
李平亚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The currently commonly used western medicines for treating hyperlipidemia include statins and fibrates. They have certain curative effects, but long-term use has certain side effects, and blood lipids tend to rebound after drug withdrawal

Method used

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  • Medicine composition for regulating blood fat
  • Medicine composition for regulating blood fat
  • Medicine composition for regulating blood fat

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0019] Experimental Example 1 The preparation method of each compound of the present invention:

[0020] Experimental materials, instruments and reagents

[0021] The aerial part of Dioscorea nipponica Makino was collected from Jingyu County, Jilin Province, and was identified as the aerial part of Dioscorea nipponica Makino by Professor Zhang Jimin, Department of Pharmacognosy, School of Pharmacy, Jilin University.

[0022] Silica gel (400-500 mesh) for column chromatography is a product of Qingdao Ocean Chemical Factory, and silica gel plate (100mm×100mm) for thin-layer chromatography is a product of Qingdao Ocean Chemical Factory. The filler used in the atmospheric pressure ODS column was produced by Tianjin Chemical Reagent Factory Chromatography Technology Development Company. All reagents used are of analytical grade, and petroleum ether is in the middle boiling range (60°C-90°C). Xinhua No.1 filter paper was used for paper chromatography. Thin-layer chromatography us...

experiment example 2

[0060] Experimental example 2 The present invention is to the impact test of hyperlipidemia mouse blood lipid

[0061] Materials and Methods

[0062] Animals 120 ICR mice, 80 males and 40 females, weighing 18-20 g. Purchased from the Animal Experiment Center of Jilin University School of Basic Medicine, animal certificate number: SCXK-(Ji)-2003-0001. Drugs and reagents Xuezhikang Capsules, specification: 300mg / capsule, batch number 20060305, produced by Beijing Beida Weixin Biotechnology Co., Ltd.;

[0063] Fenofibrate group, specification: 200mg / capsule, batch number 89396, produced by French Liboforni Pharmaceutical Company;

[0064] Cholesterol, specification: biochemical reagent, 25g / bottle, lot number: 070516, Tianjin Guangfu Fine Chemical Research Institute;

[0065] Sodium cholate, specification: biochemical reagent, batch number: 20070525, Beijing Chemical Reagent Company;

[0066] Lard, provided by the laboratory;

[0067] Serum Total Cholesterol (TC) Content Det...

experiment example 3

[0096] The preparation of experimental example 3 granules of the present invention

[0097] It is composed of the following compounds by weight percentage:

[0098] 3,7-Dihydroxy-2,4,6-trimethoxyphenanthrene 15%,

[0099] 1-(2,7-dihydroxy-4,6-dimethoxyphenanthrene)-2,7-dihydroxy-4,6-dimethoxyphenanthrene 15%,

[0100] 7-Hydroxy-2,6-dimethoxy-1,4-phenanthrenequinone 10%,

[0101] Kaempferol-3-O-β-D-glucopyranoside 15%

[0102] Kaempferol-3-O-β-rutinoside 15%

[0103] Rutin 35%.

[0104] The above-mentioned compound is added with conventional auxiliary materials for preparing granules to prepare granules.

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Abstract

The invention relates to a medicine composition for regulating blood fat, belonging to the field of medicine. The medicine composition for regulating the blood fat comprises the following compounds by weight percent: 10-35 percent of 3,7-dihydroxy-2,4,6-trimethoxy phenanthrene, 10-35 percent of1-(2,7-dihydroxy-4,6-dimethoxy phenanthrene)-2,7-dihydroxy-4,6-dimethoxy phenanthrene, 10-35 percent of 7-hydroxyl group-2,6-dimethoxy-1,4-phenanthrenequinone, 10-35 percent of kaempferol-3-O-beta-D-glucopyranoside, 10-35 percent of kaempferol-3-O-beta-rutinoside and 10-35 percent of rutin. The invention has the advantages that the ingredients of the medicine composition are all obtained by being extracted and separated from the aboveground part of dioscorea nipponica makino; the medicine composition belongs to natural products and has high capability for regulating the biological activity of the blood fat; and an optimal proportion of ingredients of compositions for treating hyperlipoidemia.

Description

technical field [0001] The invention belongs to the field of medicine. Background technique [0002] There are about 650 species of plants in the genus Dioscorea of ​​the family Dioscoreaceae in the world, among which more than 30 kinds of plants of the genus Dioscorea contain diosgenin in their rhizomes. Diosgenin is an important drug source for the synthesis of various steroid hormones and contraceptive drugs. Currently, more than 60% of the steroid hormones in the world use it as a raw material. Steroid hormone drugs are widely used in contraception, anti-inflammation, anti-rheumatism, heart disease, anti-tumor, hemostasis, anti-allergy and other diseases. They are in great demand and develop rapidly. They are an important field of drug production. Therefore, plants of this genus have important Economic Value. [0003] Hyperlipidemia is a common disease in middle-aged and elderly people, and it is also an important cause of atherosclerosis and cardiovascular and cerebro...

Claims

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Application Information

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IPC IPC(8): A61K31/09A61K31/122A61K31/7048A61P3/06
Inventor 李平亚卢丹刘金平
Owner 李平亚
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