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Sertraline hydrochloride dripping pills and the prepn

A technology of sertraline hydrochloride and sertraline hydrochloride, which is applied in the field of sertraline hydrochloride dripping pills and its preparation, can solve the problem of long disintegration time of sertraline hydrochloride tablets, affecting the therapeutic effect, dissolution rate and dissolution rate of sertraline hydrochloride To solve the problems of low rate, to achieve the effect of convenient carrying and taking, small pill size, improved dissolution rate and dissolution rate

Inactive Publication Date: 2004-09-08
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Sertraline hydrochloride tablets have long disintegration time, low dissolution rate and dissolution rate, poor absorption, low bioavailability, large proportion of excipients, inconvenient administration and poor compliance for children, the elderly, bedridden patients and patients with dysphagia. The therapeutic effect of sertraline hydrochloride

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0051] prescription:

[0052] Sertraline Hydrochloride 5g

[0053] Macrogol 6000 15g

[0054] Makes 1000 capsules

[0055] Preparation method: Take sertraline hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 matrix, stir well, use simethicone as a coolant, make pellets by drop method, and dry. have to.

example 2

[0057] prescription:

[0058] Sertraline Hydrochloride 5g

[0059] Macrogol 4000 15g

[0060] Makes 1000 capsules

[0061] Preparation method: Take sertraline hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 matrix, stir well, use simethicone as a coolant, make pellets by dropping, dry, and have to.

example 3

[0063] prescription:

[0064] Sertraline Hydrochloride 5g

[0065] Macrogol 6000 5g

[0066] Macrogol 4000 10g

[0067] Makes 1000 capsules

[0068]Preparation method: Take sertraline hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 4000 and polyethylene glycol 6000 mixed matrix, stir well, use simethicone oil as the coolant, drop The preparation method is to make pills, dry them, and obtain them.

[0069] 4. Example 4

[0070] prescription:

[0071] Sertraline Hydrochloride 5g

[0072] Glyceryl monostearate 15g

[0073] Makes 1000 capsules

[0074] Preparation method: Take sertraline hydrochloride fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten glyceryl monostearate matrix, mix well, use ice water as a coolant, make pellets by drop method, and...

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PUM

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Abstract

The present invention is Sertraline hydrochloride dripping pill prepared through superfine crushing and dripping pill producing process. The Sertraline hydrochloride dripping pill has raised disintegrating and dissolving speed, high digestion rate and digestion degree, fast acting, high stability, reduced supplementary material consumption, low production cost and easy carrying about and taking. It may be sucked in mouth or swallowed, has excellent conformity and is especially suitable for children, the aged and other patients with dysphagia.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to sertraline hydrochloride dropping pills and a preparation method thereof. Background technique [0002] Sertraline hydrochloride can selectively inhibit the reuptake of 5-hydroxytryptamine in the central nervous system, thereby increasing the concentration of 5-hydroxytryptamine in the synaptic cleft and exerting an antidepressant effect. [0003] Sertraline hydrochloride is easily absorbed when taken orally, and the time to peak plasma concentration is 6-10 hours, t 1 / 2 It takes about 26 hours to reach a stable blood level after taking the medicine for 4-7 days. The plasma protein binding rate is 97%. It is metabolized in the liver, and the metabolite is N-norsertraline. The activity is 1 / 10 of the parent drug, and it is mainly excreted in urine. Only tablets are currently on the market, which are clinically used for depression and can also be us...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/136A61P25/24
Inventor 钱进许军彭红李平朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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