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Sodium ferulic acid osmosis pump controlled release formulation and its preparation method

A technology of osmotic pump controlled release and sodium ferulate, which is applied in pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve problems that are difficult to achieve, and improve compliance, reduce the number of medications, blood The effect of stable drug concentration

Inactive Publication Date: 2004-08-25
TIANJIN PACIFIC PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is difficult to achieve controlled release of 24-hour constant drug release

Method used

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  • Sodium ferulic acid osmosis pump controlled release formulation and its preparation method
  • Sodium ferulic acid osmosis pump controlled release formulation and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Tablet prescription:

[0037] Sodium Ferulate 150g

[0038] Sodium chloride 150g

[0039] Croscarmellose Sodium 9g

[0040] Povidone K30 12g

[0041] Magnesium Stearate 1.5g

[0042] Semipermeable Membrane Prescription:

[0043] Cellulose acetate 15g

[0044] Polyethylene Glycol - 1000 3g

[0045] Moisture-proof film prescription Opadry model opadryII configuration method: put the solvent in the container, the solvent is water, and slowly add the Opadry model opadryII into the solvent while stirring, with a solid content of 8%-20%

[0046] Preparation Process:

[0047] Sieve the sodium ferulate, croscarmellose sodium, povidone K30, and magnesium stearate in the prescription separately for later use, crush and sieve the sodium chloride for later use, put the main and auxiliary materials in a container, and mix well , Add lubricant ethanol: water (1:1) to make soft materials. Granulate with a 20-mesh sieve, dry in a drying oven at 45 degrees Celsius, and granulat...

Embodiment 2

[0051] Tablet prescription:

[0052] Sodium Ferulate 1500g

[0053] Sodium chloride 750g

[0054] Sucrose 750g

[0055] Croscarmellose Sodium 90g

[0056] Povidone K300 120g

[0057] Magnesium Stearate 15g

[0058] Semipermeable Membrane Prescription:

[0059] Cellulose acetate 150g

[0060] Polyethylene Glycol-4000 20g

[0061] Moisture-proof film prescription Opadry model opadryII configuration method: put the solvent in the container, the solvent is water, and slowly add the Opadry model opadryII into the solvent while stirring, with a solid content of 8%-20%

[0062] Preparation Process:

[0063] Sieve the sodium ferulate, croscarmellose sodium, povidone K30, and magnesium stearate in the prescription separately for later use, crush and sieve the sodium chloride for later use, put the main and auxiliary materials in a container, and mix well , Add lubricant ethanol: water (1:1) to make soft materials. Granulate with a 20-mesh sieve, dry in a drying oven at 45 deg...

Embodiment 3

[0067] Tablet core prescription

[0068] Sodium Ferulate 450g

[0069]Sodium chloride 225g

[0070] Sucrose 225g

[0071] Croscarmellose Sodium 27g

[0072] Povidone K30 36g

[0073] Magnesium Stearate 15g

[0074] Semipermeable Membrane Prescription:

[0075] Cellulose acetate 45g

[0076] Polyethylene glycol-6000 4.5g

[0077] Moisture-proof film prescription Opadry model opadryII configuration method: put the solvent in the container, the solvent is water, and slowly add the Opadry model opadryII into the solvent while stirring, with a solid content of 8%-20%

[0078] Preparation Process

[0079] Sieve the sodium ferulate, croscarmellose sodium, povidone K30, and magnesium stearate in the prescription separately for later use, crush and sieve the sodium chloride for later use, put the main and auxiliary materials in a container, and mix well , Add lubricant ethanol: water (1:1) to make soft materials. Granulate with a 20-mesh sieve, dry in a drying oven at 45 degr...

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Abstract

The present invention relates to a preparation method of sodium ferulate penetration pump type controlled release preparation. It is formed from tablet core containing effective active component sodium ferulate, semi-transparent coating film, medicine-releasing hole and damp-proof film, and its tablet core contains (wt%) 40%-90% of sodium ferulate, 30%-95% of penetrating agent, 1%-8% of adhesive, 2%-10% of disintegrating agent and 0.5%-3% of lubricating agent. It can implement constant medicine release, the effective blood concentration in vivo can be retained for 24 hrs, the number of times for oral administration can be reduce, once per day, its blood concentration is stable and its side effect is small.

Description

Technical field: [0001] The invention relates to a preparation method of sodium ferulate osmotic pump type controlled release preparation Background technique: [0002] Sodium ferulate (sodium Ferulate) is a water-soluble active ingredient extracted from Angelica or Chuanxiong. The chemical name is 3-methoxy-4-hydroxy-sodium phenylacrylate. It is a commonly used drug for treating cardiovascular and cerebrovascular diseases. Its pharmaceutical dosage form There are conventional dosage forms such as ordinary tablets, powders and aqueous solutions. Due to the short biological half-life of sodium ferulate, it can be absorbed quickly after oral administration, so it can be eliminated quickly in the body. In order to maintain the effective blood drug concentration, it must be administered in a balanced manner, which will cause peaks and valleys in the blood drug. Chinese patent CN138515151 discloses a sustained-release tablet. However, due to the good water solubility of sodium ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K9/28A61K31/192A61P9/10
Inventor 宋德成
Owner TIANJIN PACIFIC PHARMA
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