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Process for preparing lactic acid oligomer

A technology of lactic acid oligomers and mixtures, applied in the field of preparation of lactic acid oligomers, to achieve the effects of improving basic metabolism, lowering blood sugar, and suppressing excessive appetite

Inactive Publication Date: 2004-05-19
AMATO PHARMA PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, it is difficult to selectively generate lactic acid oligomers by conventional methods, and the lactic acid oligomers obtained in the dehydration condensation process of lactic acid contain high polymers with too wide molecular weight distribution, so it is necessary to separate and recover lactic acid oligomers by separation methods such as chromatography. thing

Method used

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  • Process for preparing lactic acid oligomer
  • Process for preparing lactic acid oligomer
  • Process for preparing lactic acid oligomer

Examples

Experimental program
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Effect test

Embodiment 1

[0054] The reaction scheme of Example 1 is shown below.

[0055]

[0056] Lithium diisopropylamide (LDA)

[0057]

[0058] Add 0.63mL (1mmol) of n-butyllithium (1.6M hexane solution) to a 5mL THF solution of 0.101g (1mmol) of diisopropylamine at 0°C under a nitrogen atmosphere, and stir for 10 minutes to obtain diisopropylamine After lithium propylamide (LDA), a 4 mL THF solution of 0.577 g (4 mmol) of L-(-)-lactide was added, followed by stirring for 15 minutes to allow a reaction. To the reaction mixture was added 20 mL of saturated aqueous ammonium chloride to work up the reaction, and then 10 mL of water was added. It was extracted 5 times with THF (50 mL), and the organic layer was dried over anhydrous sodium sulfate. After filtering anhydrous sodium sulfate, the organic solvent was concentrated under reduced pressure to obtain 0.53 g of a crude product. The resulting crude product was added to 6 mL of ether, immersed in an ult...

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Abstract

An object of the present invention is to provide a novel method for the effective preparation of a mixture of linear and cyclic lactic acid oligomers. The present invention provides a method for the preparation of a mixture of linear and cyclic lactic acid oligomers represented by the following formula (1) or (2): wherein m represents an integer of 1 to 30, and n represents an integer of 1 to 30, wherein lactides are polymerized in the presence of a compound represented by the following formula (3): Me-N(R<1>)(R<2>) (3) wherein Me represents an alkali metal, and each of R<1 >and R<2 >independently represents an aliphatic group or aromatic group.

Description

technical field [0001] The invention relates to a preparation method for preparing a chain-like and cyclic lactic acid oligomer mixture, and a chain-like and cyclic lactic acid oligomer mixture prepared by the preparation method. Background technique [0002] Lactic acid oligomers are compounds useful as medicines such as tumor cell growth inhibitors (JP-A-3-193731 ) and anticancer agents (JP-A-9-227388 ) or their intermediates. [0003] Conventionally, such lactic acid oligomers have been produced by dehydrating and condensing lactic acid under heating in an inert atmosphere, and then separating and recovering the oligomer component from the resulting reaction product. [0004] However, it is difficult to selectively generate lactic acid oligomers by conventional methods, and the lactic acid oligomers obtained in the dehydration condensation process of lactic acid contain high polymers with too wide molecular weight distribution, so it is necessary to separate and recover l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/357A61P3/02A61P3/04A61P3/10A61P35/00A61P35/04A61P37/04A61P43/00C07D323/00C08G63/08C08G63/82
CPCC08G63/823C07D323/00A61P3/02A61P3/04A61P3/10A61P35/00A61P35/04A61P37/04A61P43/00C08G63/08
Inventor 渡边干夫村上正裕
Owner AMATO PHARMA PROD
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