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Vaccine preparation for fused virus-like granule, its production method and process of using

A technology that integrates viruses and production methods. It is applied in the fields of botanical equipment and methods, biochemical equipment and methods, and viral antigen components. It can solve the problem of low immune response, achieve easy implementation, improve the ability to stimulate a complete immune response, protect The body's resistance to pathogens

Inactive Publication Date: 2004-03-17
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Although the HBV-S antigen can form particles, and the recombinant malaria vaccine loaded on the S antigen has been included in clinical trials (Bojang, et al. 2001. Lancet 358: 1927), the immune response produced by the S antigen particles is much lower than core antigen

Method used

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  • Vaccine preparation for fused virus-like granule, its production method and process of using
  • Vaccine preparation for fused virus-like granule, its production method and process of using
  • Vaccine preparation for fused virus-like granule, its production method and process of using

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Embodiment Construction

[0042] The present invention will be further described by means of the following implementation examples:

[0043] The following implementation examples are exemplary rather than restrictive, and specific implementation manners can be determined according to the above-mentioned technical solutions of the present invention and actual conditions. Example 1. Design and synthesis of primers

[0044] According to the sequences of human hepatitis B virus core antigen and foot-and-mouth disease VP1, DNAMAN software was used to design 6 primers for amplifying the sequence of fusion virus-like particles. The designed primers are: the sequence of primer P1 is: aagaattc ggc atg gac att gac ccg tat aaa the sequence of primer P2 is: ACC TCC ACC TCC GGA ACC gtc ttc caa att act tcc c the sequence of primer P3 is: GGT TCC GGA GGT GGA GGT acc acc tct gcg ggt gag The sequence of primer P4 is: ACC TCC ACC TCC GGA ACC cag aag ctg ttt tgc ggg The sequence of primer P5 is: GGT TCC GGA GGT GGA GGT ...

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Abstract

The fusion virus-like particle contains protein capable of forming virus-like particle as carrier and fused protective target virus antigen. Specifically, human hepatitis B virus core antigen forming virus-like particle is used as the carrier, and protective target virus antigen gene segment is fused in to form fused virus-like particle, which is further mixed with adjuvant, if any, to form vaccine. The target antigen may display its surface to produce relatively high B cell activity and stimulate T cell to produce protective immunity. During use, the vaccine may be made to enter body via injection, spraying, oral taking, dropping to nose or eye, penetration, absorption or physical and chemical mediation.

Description

technical field [0001] The invention relates to the preparation of a fusion virus-like particle vaccine by using a genetic engineering method, its production method and the use method of activating, improving and regulating the body's immune response, and is a novel protein subunit vaccine preparation method and use method. Background technique [0002] There are many ways to prevent infection by various pathogens, and improving the body's immunity is the most important means, which is generally achieved by vaccination. Vaccination is an effective measure to prevent infection by various pathogens. Common pathogens are organisms and molecules such as viruses, microorganisms, eukaryotic cells, parasites, and environmental agents. Various methods have been used to produce vaccines against infectious pathogens, such as inactivated vaccines, live attenuated vaccines, recombinant vaccines, subunit vaccines and nucleic acid vaccines. Their basic pri...

Claims

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Application Information

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IPC IPC(8): A61K39/12A61P37/04C12N15/33C12N15/62
Inventor 王宾俞庆龄
Owner CHINA AGRI UNIV
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