Coated Hypericum perforatus extract micro pill preparation and its preparing process
A technology of Hypericum perforatum and film coating, which is applied in the direction of pill delivery, sugar-coated pills, drug combination, etc., can solve instability and other problems, and achieve the effects of fast drying, less weight gain, and stable chemical properties
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Embodiment 1
[0046] The composition and proportion of the pellets are:
[0047] Blank ball core 12g
[0048] Extract A 1.8g
[0049] Extract B 0.9g
[0051] Microcrystalline Cellulose 0.6g
[0052] Vitamin C 30mg
[0053] PVP 0.5g
[0054] The composition and proportion of the film coating are:
[0055] No. IV acrylic resin 0.5g
[0056] Hydroxypropyl methylcellulose 0.04g
[0058] Titanium dioxide 0.2g
[0059] Magnesium stearate 0.1g
[0060] Tween-80 0.2ml
[0061] Preparation:
[0062] 1. Preparation of Hypericum perforatum extract pellets:
[0063] (1) Add 0.4 g of talcum powder, 0.6 g of microcrystalline cellulose, and 30 mg of vitamin C to 1.8 g of extract A (passed through 100 mesh), and mix well.
[0064] (2) Dissolve 0.9 g of Extract B in 2-4 ml of 10% PVP ethanol...
Embodiment 2
[0074] The composition and proportion of Hypericum perforatum extract pellets are the same as those in Example 1.
[0075] The composition and proportion of the film coating are:
[0076] No. IV acrylic resin 0.5g
[0077] Talc powder 0.2g
[0078] Titanium dioxide 0.2g
[0079] Magnesium stearate 0.1g
[0080] PEG60000.1g
[0081] Rouge 0.05g
[0082] Preparation Process:
[0083] 1. The preparation of Hypericum perforatum extract pellets is the same as in Example 1.
[0084] 2. Film-coat the pellets:
[0085] (1) Soak No. IV acrylic resin overnight with 95% ethanol, dissolve it, and make 5% No. IV acrylic resin solution.
[0086] (2) Dissolve 0.05g carmine completely with a few drops of water, add it to 10ml No. IV acrylic resin solution, then add 0.2g talcum powder, 0.2g titanium dioxide, 0.1g magnesium stearate and PEG6000 0.1 g. After grinding repeatedly in the grinding chamber, t...
Embodiment 3
[0089] The composition and proportion of Hypericum perforatum extract pellets are the same as those in Example 1.
[0090] The composition and proportion of the film coating are:
[0091] Hydroxypropyl methylcellulose 0.2g
[0092] Titanium dioxide 0.3g
[0093] Magnesium stearate 0.3g
[0094] Glycerin 0.12ml
[0095] Preparation Process:
[0096] 1. The preparation of Hypericum perforatum extract pellets is the same as in Example 1.
[0097] 2. Film-coat the pellets:
[0098] (1) Soak hydroxypropyl methylcellulose with 80% ethanol overnight, dissolve it, and make 2% hydroxypropyl methylcellulose solution.
[0099] (2) Add 0.3 g of 100-mesh titanium dioxide and 0.3 g of magnesium stearate in sequence to 10 ml of hydroxypropyl methylcellulose solution, then add 0.12 ml of glycerin, grind repeatedly in the grinding chamber, and transfer to a spray bottle for later use.
[0100] The remaining steps are the same as the film coating steps (3) to (5) of Examp...
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