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Hyacinth bletilla micro-balls for liver and kidney arterial embolism

A technology of Bletilla striata microspheres and renal arteries, which is applied in the direction of non-active ingredient medical preparations, antineoplastic drugs, powder delivery, etc., can solve the problem that the matrix has no therapeutic effect, achieve reduced peripheral blood drug concentration, and good biocompatibility sexual effect

Inactive Publication Date: 2003-06-18
SHANGHAI INST OF PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above matrix has no therapeutic effect and is only a carrier

Method used

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  • Hyacinth bletilla micro-balls for liver and kidney arterial embolism
  • Hyacinth bletilla micro-balls for liver and kidney arterial embolism
  • Hyacinth bletilla micro-balls for liver and kidney arterial embolism

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Preparation of Bletilla striata microspheres

[0028] Take the bletilla striata polysaccharide aqueous solution with a content of 25%, w / w, filter it through a Buchner funnel under reduced pressure while it is hot, and prepare microspheres from the filtrate by spray drying.

[0029] The process parameters of spray drying encapsulation are as follows:

[0030] Inlet air temperature: 180+10°C Outlet air temperature: 95+5°C Nozzle pressure: 2.5kg / cm 2 The microspheres obtained by spray drying are spherical, and the particle size ranges from 5 μm to 50 μm. See figure 1 . Bletilla striata microspheres with different particle sizes can be obtained by controlling the viscosity and feeding speed of the Bletilla striata polysaccharide solution.

Embodiment 2

[0032] In order to improve the toughness and therapeutic effect of the microspheres, gelatin can be added to the above-mentioned bletilla striata polysaccharide solution in an amount of 50% (w / w), and the same process conditions as in Example 1 can be used to obtain a particle size of 5 μm to 50 μm. of microspheres.

Embodiment 3

[0034] Preparation of drug-loaded Bletilla striata microspheres

[0035] Take the above bletilla striata polysaccharide aqueous solution, add antineoplastic drug 5-fluorouracil, the addition amount is calculated as 50% (w / w) according to the dry weight of bletilla striata polysaccharide.

[0036] After the above-mentioned Bletilla striata polysaccharide solution and the solution (or suspension, emulsion, etc.) of the anticancer drug are uniformly mixed, spray-dry according to the method in Example 1. In order to improve the toughness and drug loading capacity of the microspheres, gelatin was added in an amount of 10% (w / w) based on the dry weight of Bletilla striata polysaccharide, and the method of this example was implemented. The drug has a high encapsulation rate in the microsphere with Bletilla striata as the skeleton.

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Abstract

A bletilla microsphere for blocking the arteriae is liver and kidney to cut off the blood supply to tumor can be used as the carrier of anticancer medicine. It is prepared through dissolving the bletilla polyose and glue (or gum) in water, filtering, adding anticancer medicine, spray drying, and solidifying by cross-linking agent. Its advnatages are high biological compatibility, better biodegradability and high anticancer effect.

Description

technical field [0001] The invention relates to a bletilla striata microsphere for anti-cancer, in particular to a bletilla striata microsphere for hepatic and renal arterial embolization, and the preparation and application of the bletilla striata microsphere. Background technique [0002] Liver cancer is a common malignant tumor in Asia. There are 250,000 new primary liver cancer patients in my country every year, and about 100,000 people die of liver cancer every year. Due to the rapid and insidious onset of liver cancer, once discovered, it is often already at an advanced stage. Surgical resection is of course the first choice, but the rate of surgical resection is only about 10%. The survival period of chemotherapy patients is generally 3 to 6 months. [0003] Based on the fact that most of the blood supply (about 95%) of liver tumors comes from the hepatic artery, while the normal liver parenchyma has dual blood supply from the portal vein and the hepatic artery. In v...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K47/36A61K47/46A61P35/00A61P43/00
Inventor 陈庆华瞿文郑传胜冯敢生
Owner SHANGHAI INST OF PHARMA IND
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