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Honeysuckle flower and coptis root powder injection and its preparing method

A technology for silver yellow powder and injection, applied in the field of medicine, can solve the problems of accelerated component degradation, solution precipitation, inconvenient use, etc., and achieve the effects of convenient transportation and use, long storage period and good stability

Inactive Publication Date: 2003-06-18
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the main components of Yinhuang injection, chlorogenic acid and baicalin, will be oxidatively degraded if left in solution for a long time, and the temperature rise will accelerate this process. The content of bacteria decreased by 20% before and after, and the content decreased by 40% after being placed at 30°C for 30 days, and if left for too long, the solution would precipitate, making the use of water needles unsafe
Moreover, the water injections freeze up in winter in the north, making it inconvenient to use, and heating and dissolving accelerates the degradation of the ingredients
It can be seen that the quality of Yinhuang injection is very unstable, thus affecting the curative effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Example 1, in a workshop below grade 100, take 125g of honeysuckle extract (containing chlorogenic acid > 18%), 200g of baicalin (purity > 92%), add 1000ml to 5000ml of water for injection, and heat it at 20°C Next, add 5% low-molecular dextran by weight of the above two components, adjust the pH to 6.5, filter the solution aseptically, spray dry the filtrate aseptically, pack into 1000 pieces, crimp the cap, and pack to obtain the finished product.

Embodiment 2

[0010] Example 2, in a workshop below grade 100, take 125g of honeysuckle extract (containing chlorogenic acid > 18%), 200g of baicalin (purity > 92%), add 1000ml to 5000ml of water for injection, and heat it at 30°C Next, add 200g-300g of mannitol, adjust the pH to 8.5, filter the solution aseptically, divide the filtrate into 1000 5ml vials, freeze-dry, and crimp the cap to obtain Yinhuang powder for injection.

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PUM

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Abstract

A powder injection for treating upper respiratory tract infection, acute tonsillitis, and pharyngitis is prepared from the honeysuckle flower's extract whose main component is chlorogenic acid, baicalein and water-soluble additive for injection. Its advantages are high curative effect and stability, and long storage time.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a silvery yellow powder for injection for treating upper respiratory tract infection, acute tonsillitis, pharyngitis and other diseases and a preparation method thereof. Background technique [0002] Yinhuang has the effects of clearing away heat, detoxifying, and soothing the throat. It is used for acute tonsillitis, upper respiratory tract infection, and wind-heat invading the lungs resulting in fever, cough, and sore throat. Yinhuangzhen, tablets, granules, capsules and oral liquids made from honeysuckle and Scutellaria baicalensis extracts have all come out. However, the main components of Yinhuang injection, chlorogenic acid and baicalin, will be oxidatively degraded if left in solution for a long time, and the temperature rise will accelerate this process. The content of bacteria decreased by 20% before and after, and the content decreased by 40% after being p...

Claims

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Application Information

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IPC IPC(8): A61P11/00A61P11/04
Inventor 张卫东周耘苏娟
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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