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Medicine for promoting recovery of renal function

A kidney function and drug technology, applied in the field of drugs for promoting renal function recovery, can solve the problems of insufficient donors, unclear mechanism of action, and large volume of traditional Chinese medicine compounds.

Inactive Publication Date: 2003-03-05
龙勉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, limited by the shortage of donors, rejection and high cost, the patients who can benefit are limited
Although there are various compound prescriptions of traditional Chinese medicine for renal insufficiency, they also have certain curative effect, but the traditional Chinese medicine compound prescription is bulky, inconvenient to take, and the mechanism of action is not clear enough

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Example 1: Drynaria fortunei 500g, reflux distillation with 50% ethanol 5000ml for 60 minutes, extract three times, evaporate the organic solvent, redissolve in 500ml water, extract three times with ethyl acetate, 500ml each time, pass through the silica gel column layer after concentration The fraction was collected by gradient elution with n-hexane:acetone (95:5 to 0:100). Prepare injections, tablets, capsules and granules according to conventional methods. Its unit dose contains drynaria flavonoids and steroids 5-500 mg.

Embodiment 2

[0012] Embodiment 2: Drynaria fortunei 500g, heating water 5000ml, decoct twice, first time 1 hour, second time 30 minutes, filter, go up polyamide column (or macroporous adsorption resin), collect 20% to 90% The ethanol eluate, the solvent is recovered under reduced pressure, spray-dried, and then made into injections, tablets, capsules, and granules according to conventional methods. The unit dose contains 5-500 mg of total flavonoids and total steroids of drynaria.

Embodiment 3

[0013] Example 3: Drynaria fortunei 500g was added with 50% ethanol 5000ml, heated and extracted twice, the solvent was recovered under reduced pressure, spray-dried, and then prepared into injections, tablets, capsules, and granules according to conventional methods. The unit dose contains 5-500 mg of total flavonoids and total steroids of drynaria.

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PUM

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Abstract

The medicine for promoting renal function recovery is total flavone and total steroid extracted from single Chinese medicine drynaria rhizome. It can be made into injection, tablet, capsule and granules, and its unit dosage contains 5-500 mg of total flavone and total steroid of drynaria rhizome. The tests show that said medicine can improve the function of renal tubular epithelial cell, promoting regeneration of renal tubular epithelial cell, raising excretory function of kidney organ so as to promote internal secretion of kidney and other functions to improve renal function and cure renal failure and secondary diseases due to renal insufficiency. The purified total flavone and total steroid effective component content is high, toxicity is reduced, can be used in renal dialysate.

Description

technical field [0001] The invention relates to a medicine for improving renal function to treat and prevent diseases related to insufficient renal function, such as secondary deafness, osteoporosis, hair loss and even renal failure. Background technique [0002] Renal insufficiency is a disease caused by multiple reasons such as poisons, drugs, infection, trauma, age, and secondary diseases of other organs. Severely insufficient kidney function is called renal failure. Renal insufficiency can not only impede kidney and urinary function, but also cause deafness, osteoporosis, hair loss and other diseases. The current treatment methods for renal failure mainly include renal dialysis, kidney transplantation, or traditional Chinese medicine compound. Kidney dialysis is an artificial way to replace the function of the kidneys to remove toxins from the body, so as to improve the symptoms of nephrotoxicity and prolong the patient's life. The essence of its treatment cannot prom...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61P13/12
Inventor 龙勉本杰明杰拉夫特(BENJAMINJ.LUFT)
Owner 龙勉
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