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Antalgic medicine for cancerous pain and its preparing process

A technology for cancer pain and drugs, which is applied in the field of preparation of the drug, can solve the problems of cancer pain patients not being well treated and clinical application limitations, and achieve the effects of no toxic side effects, long acting time, and good analgesic effect

Inactive Publication Date: 2002-11-13
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, the abuse and dependence of this type of drug have increased significantly, and the resulting serious social problems have become increasingly prominent, which has severely restricted the clinical application of this type of drug, resulting in many cancer pain patients who have not yet received treatment. Good treatment, management of cancer pain remains a thorny issue for doctors

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Weigh 500g of Qingfengteng, 1000g of celandine, and 1000g of Chinese peach leaves. The above three flavors, celandine, and Qingfengteng add 10 times the amount of 85% ethanol to soak for 24 hours, heat and reflux 3 times, each time for 2.5 hours, combine the alcohol extracts, recover the ethanol under reduced pressure and concentrate to 1:1, use 1.5mol / L phosphoric acid to adjust the pH to 2.3, let it stand for 24 hours, filter, adjust the pH of the filtrate to 11 with 60% sodium hydroxide solution, extract 6 times with an equal amount of chloroform, combine the chloroform liquid, recycle the chloroform, and dry the residue in vacuum to obtain total alkaloids. Decoct Chinese peach leaves with water for 3 times, 2 hours each time, combine the decoction liquid, filter, concentrate the filtrate under reduced pressure, and use ethanol precipitation treatment twice. The alcohol content of the first solution reaches 70%, and the second time reaches 80%. %, filter each time,...

Embodiment 2

[0018] Weigh 800g of Qingfengteng, 700g of celandine, and 1000g of Chinese peach leaves. The above three flavors, celandine, and Qingfengteng add 8 times the amount of 80% ethanol to soak for 2 hours, heat and reflux twice, each time for 2 hours, combine the alcohol extracts, recover the ethanol under reduced pressure and concentrate to 1:1, use 1mol / Adjust the pH to 3.1 with L phosphoric acid, let stand for 18 hours, filter, adjust the pH to 10 with 40% sodium hydroxide solution in the filtrate, extract 5 times with an equal amount of chloroform, combine the chloroform liquid, reclaim the chloroform, and dry the residue in vacuum to obtain the total alkaloids. Decoct Chinese peach leaves with water for 2 times, each time for 1.5 hours, combine the decoction liquid, filter, concentrate the filtrate under reduced pressure, and use ethanol precipitation treatment twice. The alcohol content of the first solution reaches 60%, and the second time reaches 85%. %, filter each time,...

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PUM

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Abstract

An antalgic medicine as Chinese medicine in the form of injection for treating cancerous pain is prepared from 3 Chinese medicinal materials including orientvine stem, greater celandine herb, etc. through respectively extracting general alkaloid and dried extract, mixing with water for injection, tween-80 and phenylmethanol, filtering and sterilizing to obtain the injection. Its advantages are high antalgic effect, durable acting time, and no toxic by-effect.

Description

Technical field [0001] The invention relates to a medicine for analgesic cancer pain, and also relates to a preparation method of the medicine. Background technique [0002] Cancer pain is a common worldwide problem. Effective analgesic treatment, especially for advanced cancer patients, is one of the four priorities of the World Health Organization's Comprehensive Cancer Programme. According to the statistics of the World Health Organization, there are about 7 million new cancer patients in the world every year, and more than 4.3 million deaths, of which 30 to 50% of the patients are accompanied by different degrees of pain when they die. The mechanism of cancer pain in modern medicine has not been fully clarified. [0003] Currently, cancer pain is still a difficult disease to conquer. The World Health Organization recommends a three-step therapy for the treatment of cancer pain. For mild pain, use non-opioid analgesics, such as: paracetamol, aspirin, ibuprofen, naprox...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61P29/00A61P35/00
Inventor 张平
Owner JIANGSU KANION PHARMA CO LTD
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