Recombinant adenovirus for preventing baby's diarrhea

Abstract

A recombinant adenovirus for preventing baby's diarrhea by preparing its nosal drops, spray, injection and orally applied preparation. It features that its genoma has the deficiency of E1 region (delta E1 ) and E3 region (delta E3) and the gene expression box VP6 of rotavirus is inserted at said deficient positions. Its advantages include high immune effect and safety, low cost and easy storage and preparing.

Description

(1) Technical field [0001] The invention relates to a recombinant adenovirus for preventing diarrhea in infants and belongs to the field of biological genetic engineering. (2) Background technology [0002] Rotavirus is the most important cause of diarrhea in infants and young children, and it is widely prevalent in the world. According to the report of the World Health Organization, there were 3 to 5 billion cases of diarrhea in Asia, Africa, and Latin America in 1977-1978. , resulting in the death of 5-10 million children, ranking first in both morbidity and mortality. In another report, it is estimated that in Asian, African, and Latin American countries, there are 700-100 million diarrhea cases and 4.6 million deaths each year. Diarrhea, even in developed countries such as the United States, is very harmful. The total expenditure for the treatment of rotavirus infection in the United States exceeds 1 billion U.S. dollars every year. Diarrhea ranks second in the cause of de...

AI Technical Summary

Problems solved by technology

[0002] Rotavirus is the most important cause of diarrhea in infants and young children, and it is widely prevalent in the world. According to the report of the World Health Organization, there were 3 to 5 billion cases of diarrhea in Asian, African, and Latin American countries in 1977-1978. , resulting in 5-10 million child deaths, ranking first in both morbidity and mortality. In another report, it is estimated that in Asian, African, and Latin countries, there are 700-100 million diarrhea cases and 4.6 million deaths each year. Diarrhea, even in developed countries such as the United States, is very harmful. The total expenditure for the treatment of rotavirus infection in the United States exceeds 1 billion U.S. dollars every year. Diarrhea ranks second in the cause of death of infants and young children in my country. From this point of view, rotavirus disease Infected diarrhea not only causes a large number of infant deaths, but also causes economic losses. At present, there is no specific drug for treatment. Therefore, preventing rotavirus infection is an important task to reduce the occurrence of the disease. Therefore, research and development of rotavirus vaccines , can reduce morbidity and mortality, so that infants and young children can reduce the suffering of diarrheal diseases and the threat of death

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