Reagent for separating amino acid enantiomer

An enantiomer and amino acid technology, applied in the field of mass transfer and separation, can solve the problems of limited varieties of chiral catalysts, insufficient product optical rotation, complicated product processing technology, etc., and achieves large partition coefficient, high economy, and chiral selectivity. high effect

Inactive Publication Date: 2007-08-22
TSINGHUA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] There are two ways to obtain a single enantiomer in industry: the first way is the asymmetric synthesis method, which uses chiral catalysts such as enzymes to synthesize a single enantiomer. This method has problems such as high cost and product optical rotation. Insufficient, cumbersome post-processing technology of products, limited variety of chiral catalysts, etc. Therefore, it is only suitable for the production of a small amount of enantiomeric drugs at present, and a large number of single enantiomeric drugs must rely on the second way, that is, chiral catalysts. Material Separation Technology

Method used

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  • Reagent for separating amino acid enantiomer

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Embodiment Construction

[0008] The novel reagent used for amino acid enantiomer separation described in the present invention is prepared by the following method: chiral molecule D-dibenzoyl tartaric acid or L-dibenzoyl tartaric acid with a molar concentration ratio of 1:1 to 40 and dibenzoyl tartaric acid (2-Ethylhexyl)phosphoric acid is mixed, diluent n-octanol is added to it, and after stirring, unreacted chiral molecules containing D-dibenzoyl tartaric acid or L-dibenzoyl tartaric acid, di(2-ethyl Base hexyl) phosphoric acid, and the mixed solution system that reacts to form a chiral intermediate complex, and the prepared mixed solution system is a new reagent for the separation of amino acid enantiomers.

[0009] The present invention will be described below in conjunction with specific embodiments.

[0010] Reagent 1:

[0011] At normal temperature (25°C) and normal pressure (101.3kPa), accurately weigh 0.358g (0.001mol) D-DBTA or L-DBTA and 0.322g (0.001mol) D2EHPA into a 100ml volumetric fla...

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Abstract

The invention relates to a new pattern agent for separating amino acid enantiomer, which belongs to the mass transfer isolation technique field about chemical industry, chemical and medicine. The invention discloses the new pattern agent to solve the problem which both the low selective and small flux of chiral selectors hinder the chirality enantiomer drugs industrial mass production seriously, which comprises: mixing the chirality molecule D-dimethylbenzoyl tartaric acid or L-dimethylbenzoyl tartaric acid with the mole ratio as 1:1-40 and D2EHPA, adding octanol as deflocculating agents, and stirring to get the D-dimethylbenzoyl tartaric acid, L-dimethylbenzoyl tartaric acid or D2EHPA with unreactive chiral molecules and the mixture liquid system of intermediate complex compound from the reaction formation. The mixture liquid system is the said new pattern agent for separating amino acid enantiomer.

Description

technical field [0001] The invention belongs to the technical field of mass transfer separation related to chemical industry, chemistry, medicine and the like. Background technique [0002] The physical and chemical properties of chiral enantiomers are the same, but due to the difference in spatial structure, there are great differences in the biological activities of many chiral enantiomers, such as pharmacodynamics and pharmacokinetics, and the use of racemic drugs may lead to wrong Pharmacological behavior and mode of action. Therefore, in 1992, the U.S. Food and Drug Administration (FDA) stipulated that in the future, any drug with an asymmetric center must be given the result of chiral separation and the efficacy of a single enantiomer. The European Community has also adopted a corresponding measure. Affected by this regulation, the sales of single-enantiomer chiral drugs in the world are increasing year by year, and their proportion in the global drug market is also ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C227/40B01D11/00
Inventor 谭斌骆广生汪家鼎
Owner TSINGHUA UNIV
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