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Compound phenformin

A hypoglycemic drug and compound technology, applied in the field of compound hypoglycemic drugs, can solve problems such as difficulty in diabetic syndrome and hypoglycemia, and achieve the effects of improving microcirculation, lowering blood pressure, and improving human bioavailability

Inactive Publication Date: 2007-04-11
天津市若围药物研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, single preparations such as berberine hydrochloride or sulfonylurea drugs are often used clinically to lower blood sugar in patients. Although these drugs have certain hypoglycemic effects and have certain curative effects on diabetes, if the dosage of sulfonylurea drugs If it is too large, hypoglycemia and other phenomena will often appear, especially for many diabetic syndromes, it is difficult to work

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1: compound hypoglycemic capsule

[0012] Each 1000 compound hypoglycemic capsules contains the following substances:

[0013] Gliclazide 20g

[0014] Berberine Hydrochloride 250g

[0015] Sodium alginate 100g

[0016] Soluble starch 72g

[0017] Alginic acid 50g

[0018] Hydroxypropyl Cellulose 5g

[0019] Magnesium Stearate 3g

[0020] According to the above prescription, firstly, the main ingredients were subjected to ultra-micronization treatment, so that the fineness reached 40 μm; 72 g of soluble starch and 20 g of gliclazide were mixed in equal increments, and fully stirred evenly, and then passed through a 120-mesh sieve; Mix 50g alginic acid and 100g sodium alginate diester evenly, and pass through a 100-mesh sieve; take 5g hydroxypropyl cellulose and 3g magnesium stearate, mix evenly, and pass through a 100-mesh sieve; mix the above raw and auxiliary materials evenly and put them into No. 0 Or No. 1 capsule and mak...

Embodiment 2

[0021] Embodiment 2: Compound Jiangtang Tablets

[0022] Each 1000 tablets of compound hypoglycemic tablets contains the following substances:

[0023] Glibenclamide 1.25g

[0024] Berberine Hydrochloride 250g

[0025] Sodium alginate 100g

[0026] Modified starch 15g

[0027] Microcrystalline Cellulose 15g

[0028] Starch slurry (20%) 15g

[0029] Magnesium Stearate 3g

[0030] According to the above prescription, the main ingredients were firstly subjected to ultra-micronization treatment to make the fineness reach 100 μm; the auxiliary materials were weighed and passed through a 120-mesh sieve; 15 g of modified starch and 1.25 g of glibenclamide were mixed evenly in an equal increment method, And pass through a 120 mesh sieve, then mix with 250g berberine hydrochloride, 100g sodium alginate diester and 15g microcrystalline cellulose for 30 minutes; 15g concentration of 20% starch slurry is added to the mixed powder to make soft material, a...

Embodiment 3

[0031] Embodiment 3: Compound hypoglycemic granules

[0032] Each 1000 bags of compound hypoglycemic granules contains the following substances:

[0033] Glipizide 2.5g

[0034] Berberine Hydrochloride 250g

[0035] Sodium alginate 100g

[0036] Xylitol 100g

[0037] Soluble starch 25g

[0038] Hydroxypropyl Cellulose 10g

[0039] Menthol 0.05g

[0040] Starch slurry (10%) 20g

[0041] According to the above prescription, firstly, the main ingredients are subjected to ultra-micronization treatment, so that the fineness reaches 60 μm and 90 μm, each accounting for 50%; take 25 g of soluble starch and 2.5 g of glipizide and mix them uniformly in equal increments, and pass through 120 mesh Sieve; take 100g xylitol and 250g berberine hydrochloride and mix evenly, pass through a 100 mesh sieve; take 10g hydroxypropyl cellulose and 100g sodium alginate diester, mix uniformly, pass through a 100 mesh sieve; mix the above raw and auxiliary materi...

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PUM

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Abstract

A compound hypoglycemic medicine in the form of tablet, capsule, particles, or powder for decreasing the sugar, pressure, fat and viscosity of blood is prepared from the fine powder of sulfonylurea medicines, the fine powder of berberine hydrochloride, biliposodium alginate, diluent, adhesive, disintegrant, lubricant, flowing aid, antisticking agent and slow releasing agent. Its advantages are high biological utilization rate, low dosage and low by-effect.

Description

technical field [0001] The invention relates to a medicine, in particular to a compound hypoglycemic medicine capable of treating diabetes. Background technique [0002] With the improvement of people's living standards, the global incidence of diabetes is increasing year by year. Diabetes has become the third major disease threatening human health after malignant tumors and cardiovascular diseases. This disease is a common endocrine disease, which is a complex disease of endocrine disorders and metabolic disorders caused by abnormal insulin function. Most patients with diabetes are accompanied by symptoms such as high blood lipids, high blood viscosity, high blood pressure, and arteriosclerosis. People with diabetes for a long time will also develop retinopathy, resulting in vision loss or even blindness. They may also experience peripheral neuropathy due to circulatory disturbance Various complications such as lower extremity ulceration. At present, berberine hydrochlor...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/715A61K31/4745A61K31/64A61P3/10
Inventor 张志毅刘世珍
Owner 天津市若围药物研究所
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