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Guanido vitriol compound and its extraction and separation method

A separation method and compound technology are applied in the field of compounds to achieve the effects of small molecular weight, simple and feasible method and novel structure

Inactive Publication Date: 2007-04-04
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far no compound has been found that contains both sulfur and guanidine

Method used

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  • Guanido vitriol compound and its extraction and separation method
  • Guanido vitriol compound and its extraction and separation method
  • Guanido vitriol compound and its extraction and separation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] A kind of guanidine sulfuric acid compound structural formula is as follows:

[0017]

[0018] Its extraction and separation method uses the wrinkled soft sponge (Halichondria rugosa Ridley&Dendy) from the South China Sea as a raw material, and adopts the method of combining a normal-phase column and a reverse-phase column, which can be operated as follows:

[0019] The wrinkled soft sponge (Halichondria rugosa Ridley&Dendy) from the South China Sea was collected, stored in a -20°C refrigerator immediately after collection, freeze-dried (100 g) before use, crushed, mechanically stirred in methanol for extraction, and repeated 4 times. The extracts were combined and reduced. Concentrate to a slurry by pressure distillation, disperse the slurry evenly in 100ml of water, and extract three times successively with an equal amount of cyclohexane, ethyl acetate, and n-butanol respectively, and concentrate the n-butanol extract under reduced pressure. The product was eluted ...

Embodiment 2

[0025] 2 kg of the collected fresh sponge was minced, directly stirred and extracted with 2000 ml of methanol, the extract was concentrated to 1000 ml, and then extracted and separated sequentially in the same manner as in Example 1 to obtain colorless needle-like crystals.

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Abstract

The invention relates to guanidino sulfate compound with structural formula shown as the figure by column separation technique. This invention has fresh structure and well application future.

Description

technical field [0001] The present invention relates to the compound separated from sponge, specifically a kind of sulfuric acid guanidinium compound and its extraction and separation method. Background technique [0002] Sponges are lower multicellular animals and the largest source of natural products. At present, a variety of natural products have been isolated from sponges, mainly terpenes, alkaloids, brominated compounds, steroids, etc., many of which have unique chemical structures, and have obvious antibacterial, anti-inflammatory, anti-tumor, etc. activity, and some have entered the clinical trial stage. [0003] Sulfur is the fourth largest element in seawater, so marine organisms contain a large number of sulfur-containing compounds. Relatively speaking, there are not many sulfur-containing compounds isolated from sponges. Nearly 100 compounds containing sulfuric acid groups were isolated from sponges. , (Document 1: Jean-Michel Kornprobst, ClaireSallenave and Gi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C309/15C07C303/44
Inventor 靳艳张卫虞星炬金美芳
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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