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Magnetic slow release 5-aminosalicylic acid with intercalate structure and its preparation method

An aminosalicylic acid and magnetic technology, which is applied in the assembly field of magnetic supramolecular intercalation structure sustained-release 5-aminosalicylic acid, can solve the problems of residual in vivo and incomplete degradation, and can shorten the treatment time and improve the treatment. effect of effect

Inactive Publication Date: 2006-11-08
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this kind of polymer coating materials all have phenomena such as residues in the body and incomplete degradation.

Method used

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  • Magnetic slow release 5-aminosalicylic acid with intercalate structure and its preparation method
  • Magnetic slow release 5-aminosalicylic acid with intercalate structure and its preparation method
  • Magnetic slow release 5-aminosalicylic acid with intercalate structure and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (1). Accurately weigh 0.012mol of Zn(NO 3 ) 2 ·6H 2 O and 0.003mol of Al(NO 3 ) 3 9H 2 O use 200ml of water to make a mixed salt solution A with a Zn / Al molar ratio equal to 4, and then add 0.0009835mol of MgFe 2 o 4 Add to mixed salt solution A;

[0039] (2). In addition, 0.038mol of NaOH and 0.008mol of 5-ASA former drug are made into mixed alkaline solution B with 100ml of water;

[0040] (3). In N 2 Slowly drop the mixed alkali B solution into the vigorously stirred mixed salt A solution under protection. After the dropwise addition, use 0.1M NaOH to adjust the final pH value to 8.4;

[0041] (4). The resulting slurry was crystallized at 60°C for 48 hours, filtered, washed, and dried in vacuum at room temperature for 72 hours to obtain 5-ASA-LDHs / MgFe 2 o 4 . The water used in the process is decarbonized deionized water.

[0042] The obtained 5-ASA-LDHs / MgFe 2 o 4 Carried out X-ray powder diffraction characterization, the results are shown in figure ...

Embodiment 2

[0049] (1). Accurately weigh 0.012mol of Zn(NO 3 ) 2 ·6H 2 O and 0.003mol of Al(NO 3 ) 3 9H 2 O Use 200ml of water to make a mixed salt solution A with a Zn / Al molar ratio of 4, and add 0.00008mol of NiFe 2 o 4 ;

[0050] (2). In addition, 0.038mol of NaOH and 0.008mol of 5-ASA former drug are made into mixed alkaline solution B with 100ml of water;

[0051] (3). In N 2 Slowly drop the mixed alkali B solution into the vigorously stirred mixed salt A solution under protection. After the dropwise addition, use 0.1M NaOH to adjust the final pH value to 8.4;

[0052] (4). The resulting slurry was crystallized at 60°C for 48 hours, filtered, washed, and dried in vacuum at room temperature for 72 hours to obtain 5-ASA-LDHs / NiFe 2 o 4 . The water used in the process is decarbonized deionized water.

[0053] The resulting 5-ASA-LDHs / NiFe 2 o 4 VSM characterization was carried out, and the specific saturation magnetization of the product was 2.78emu / g.

[0054] After ana...

Embodiment 3

[0057] (1). Accurately weigh 0.008mol of Mg(NO 3 ) 2 ·6H 2 O and 0.004mol of Al(NO 3 ) 3 9H 2 O Use 200ml of water to make a mixed salt solution A with a Mg / Al molar ratio equal to 2, and add 0.0009835mol of MgFe 2 o 4 ;

[0058] (2). The NaOH of 0.038mol and the 5-ASA former drug of 0.008mol are made into mixed alkali solution B with 100ml water;

[0059] (3). In N 2 Under protection, slowly drop the mixed alkali B solution into the vigorously stirred mixed salt A solution. After the dropwise addition, use 0.1M NaOH to adjust the final pH value to 9.5;

[0060] (4). The resulting slurry was crystallized at 60°C for 48 hours, filtered, washed, and dried in vacuum at room temperature for 72 hours to obtain 5-ASA-LDHs / MgFe 2 o 4. The water used in the process is decarbonized deionized water.

[0061] The obtained 5-ASA-LDHs / MgFe 2 o 4 VSM characterization was carried out, and the specific saturation magnetization of the product was 1.76emu / g.

[0062] The empirica...

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Abstract

The invention relates to 5-aminosalicylic acid of slow- released type in magnetic intercalated structure and the preparation method thereof. The invention has NFe204 of spinel type as magnetic material, LDHs of anion layered material as host, 5aminosalicylic acid as intercalated object. Firstly the spinel nanopowders are added into soluble mixed salt solution comprising metal ion of bivalence and tervalence, then which is intercalation-assembled with alkali solution of 5-aminosalicylic acid, 5ASA-LDHs / NFe204 of supra molecular is thus obtained. Said magnetic 5-amino salicylic acid slow-released formulation is composed of the structure of shell / nucleus type, that is the layered material is coated outside with NFe204 nanoparticles, the specific saturation magnetization of which is 1.0-4.Oemu / g, the particle size of which is around 25-120nm. The invention imparts the medication with magnetism, and the medication is targeted to a focus location by the lead of outside magnetism. The treatment time is reduced and the treatment effect is improved.

Description

Technical field: [0001] The invention relates to a magnetic drug slow-release agent and a preparation method thereof, in particular to a method for assembling slow-release 5-aminosalicylic acid with a magnetic supramolecular intercalation structure. Background technique: [0002] Magnetic sustained-release drugs are a type of drugs that combine magnetism and controlled release. Different from traditional magnetic drugs and sustained-release drugs, when such drugs are used in the body, the magnetic field effect outside the body can guide the drug to move in the body. and localized concentration, and realize the controlled release of drugs. Currently, such drugs are mainly used as anticancer drug carriers. Animal experiments and clinical observations have proved that magnetic species have the definite effect of inhibiting the growth of cancer cells, shrinking tumors and improving subjective symptoms of patients. [0003] Existing magnetic sustained-release agent medicine has...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/60A61K9/20A61P1/04A61P1/00A61K9/00A61K9/51A61K31/606A61K33/26A61K41/00A61K45/06
CPCA61K9/0009A61K9/5115A61K31/606A61K33/26A61K41/00A61K45/06A61P1/00A61P1/04B82Y5/00A61K2300/00
Inventor 段雪张慧孙辉
Owner BEIJING UNIV OF CHEM TECH
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