Chinese medicine prepn containing arasaponin and its prepn process

A technology of Panax notoginseng saponins and ginsenosides is applied in the directions of medical preparations containing active ingredients, pharmaceutical formulations, drug delivery, etc., and can solve the problems of irritation at the injection site, inconvenient administration, and influence on drug acceptability, etc. Achieve pure white color, increase acceptability, and facilitate administration

Inactive Publication Date: 2005-05-04
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The curative effect of the injection is definite, but because it is easy to cause irritation to the injection site, and the administration is inconvenient, it affects the acceptability of the drug

Method used

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  • Chinese medicine prepn containing arasaponin and its prepn process
  • Chinese medicine prepn containing arasaponin and its prepn process
  • Chinese medicine prepn containing arasaponin and its prepn process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Take 1g of Avicel PH-101 and 1g of PNS and place them in a mortar, add 20ml of distilled water, and grind in a grinder for 50min at a speed of 200rpm. Then freeze-dry in a freeze dryer for 18 hours, pass through a 200-mesh sieve, and obtain a dry powder spray.

Embodiment 2

[0040] Take 5g of Avicel PH-103 and 2g of PNS and place them in a mortar, add 100ml of distilled water, and grind in a grinder for 50min at a speed of 400rpm. Then freeze-dry in a freeze dryer for 24 hours, and pass through a 200-mesh sieve to obtain a dry powder spray.

Embodiment 3

[0042] Take 3g of calcium carbonate and 5g of PNS and place them in a mortar, add 50ml of distilled water, and grind in a grinder for 50min at a speed of 500rpm. Then freeze-dry in a freeze dryer for 22 hours, pass through a 220-mesh sieve to obtain a dry powder; take 1 g of hydroxypropyl cellulose and swell it in 100 ml of distilled water for 12 hours, then fully stir to disperse evenly and become a transparent gel matrix; Stir and mix the dry powder to obtain a gel spray with a PNS concentration of 50 mg / ml.

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PUM

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Abstract

The invention belongs to the field of traditional Chinese medicine pharmacy, and in particular relates to a traditional Chinese medicine preparation containing Panax notoginseng saponins and a preparation method thereof. The present invention adopts the total saponins of Panax notoginseng as the active ingredient, adds dry powder agent and gel agent agent, and freeze-dries to prepare dry powder sprays, gel sprays and suspension sprays of other non-injection routes of administration other than oral administration. new dosage forms. Animal tests of the present invention prove that the bioavailability is high, the administration is convenient, the administration site is non-irritating, and the patient's compliance is good.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and in particular relates to a traditional Chinese medicine preparation containing Panax notoginseng saponins and a preparation method thereof. Background technique [0002] Chinese medicine Panax notoginseng, also known as Tianqi, scientifically named Panax notoginseng (Buck.) F.H.Chen, is produced in Yunnan and Guangxi, my country, and is a species of Panax ginseng in the family Araliaceae. It has a wide range of pharmacological effects and has an impact on all major systems of the body. It is also known as an "adaptive" drug along with ginseng. Its root tuber is used in traditional medicine, which has the functions of stopping bleeding, activating blood circulation, relieving pain, anti-inflammation, etc., and can enhance the body's defense function. It is known that dencichine, a hemostatic active ingredient isolated from the traditional Chinese medicine Panax notoginseng...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/72A61K31/704A61P9/10
Inventor 方晓玲许清芳陈道峰
Owner FUDAN UNIV
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