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Synthesis of trichlorosucrose

A synthesis method and technology of sucralose, applied in chemical instruments and methods, disaccharides, sugar derivatives and other directions, can solve the problems of complex process and high production cost, and achieve the effects of simple process, low production cost and high product purity

Inactive Publication Date: 2004-11-17
广东广业清怡食品科技股份有限公司
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AI Technical Summary

Problems solved by technology

These synthetic methods have a certain degree of advancement, but there are also certain limitations, such as complex processes and high production costs.

Method used

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  • Synthesis of trichlorosucrose
  • Synthesis of trichlorosucrose

Examples

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Embodiment Construction

[0014] ①Synthesis of sucrose-6-acetate

[0015] Add 60g of sucrose, 250ml of N,N-dimethylformamide, 100ml of ethyl acetate, 1g of cerium sulfate-silica gel (1:1) into a 1000ml three-necked flask, heat to 80°C and react for 4 hours under stirring, cool to 5 DEG C, the catalyst was recovered by filtration, ethyl acetate was recovered from the mother liquor under normal pressure, and DMF was recovered under reduced pressure to obtain 68 g of syrup, which contained 83.4% of sucrose-6-acetate as measured by HPLC (equipped with a differential detector).

[0016] ②Synthesis of sucralose-6-acetate

[0017] Take the above 68g syrup and dissolve it with 400ml N, N-dimethylformamide, cool to -20°C, add 100ml of thionyl chloride dropwise, control the rate of addition, keep the temperature below 0°C during the dropping process, , and stirred at 0° C. for 30 minutes, then slowly raised the temperature to 110° C., and kept at 110° C. for 4 reaction hours. The reaction solution was cooled t...

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Abstract

The present invention discloses the synthesis of trichlorosucrose. Sucrose material is mixed with N, N-dimethyl formamide solution, made to produce ester exchange reaction with ethyl acetate in the action of solid sulfate catalyst, which may be adsorbed on polymer carrier, to produce sucrose-6-acetate. Sucrose-6-acetate is then chlorohydrinated to produce trichlorosucrose. The present invention has the advantages of simple technological process, high product purity, low production cost, etc. and is suitable for industrial production.

Description

Technical field [0001] The invention relates to a synthesis method of food sweetener-sucralose. Background technique [0002] Sucralose, chemical name 4,1',6'-trichloro-4,1',6'-trideoxygalactose, its structural formula is: [0003] [0004] Sucralose is 600 times sweeter than sucrose and has been approved as a food sweetener by more than 20 countries. [0005] The preparation methods of sucralose generally fall into two categories: single group protection method and whole group protection method. The whole group protection method (as recorded in US Pat. To make other hydroxyl groups react while the 6-position hydroxyl group remains unchanged, group protection of the 6-position hydroxyl group is required, which is the starting point for the consideration of single-group protection. Therefore, the core of the single-group protection method is the preparation of sucrose-6-acetate. The structural formula of sucrose-6-acetate is: [0006] [0007] The synthetic method ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H1/00C07H3/04C07H3/08C07H5/02C07H13/04
CPCC07H13/04C07H5/02C07H1/00
Inventor 王三永李春荣李晔曹敢星
Owner 广东广业清怡食品科技股份有限公司
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