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Separation and purification method of dodecanedioic acid

A dodecanedioic acid and purification method technology, which is applied in the field of separation and purification of dodecanedioic acid produced by fermentation, can solve the problems of no further disclosure of technical solutions, imperfect post-processing technology, complicated solvent recovery, etc., and achieve The effect of cleaning the production process route, facilitating industrial application, and eliminating the solvent recovery process

Inactive Publication Date: 2004-07-28
SHANGHAI RES INST OF CHEM IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with the production of dodecanedioic acid by chemical synthesis, the biological fermentation method has great advantages in terms of production technology, safety and economy. However, due to the imperfect post-treatment process of the fermentation product, the product purity is not high. To be perfected by further research work in the future
[0003] In the prior art, Japanese Patent Laid-Open No. 58-193694 discloses a post-treatment process for the production of dodecanedioic acid by fermentation. It adopts a mixed solvent high-temperature extraction and cooling crystallization method to separate and purify dodecanedioic acid. The purity of the product reaches 99%, and the nitrogen content is less than 100ppm. However, the process of this method is complicated. During the purification process, circulation extraction is required at a temperature of 100°C. The energy consumption is high, and the recovery of the solvent is also relatively complicated.
[0004] Fushun Petrochemical Research Institute introduced a post-treatment process for the long-chain tridecane dibasic acid fermentation broth (Modern Chemicals, 1996, 1:22-24). This process uses a solvent-free method for purification, and the separation process is relatively simple, and Use microfiltration to remove mycelium, but the article does not further disclose detailed technical solutions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take 1000 mL of biological fermentation broth of dodecanedioic acid, add 30 g of activated carbon at 70° C. for decolorization, stir, and filter to obtain a filtrate. The temperature of the filtrate was kept at 40° C., 11 mg of ethylenediaminetetraacetic acid was added and stirred for 20 minutes, then 14 mg of chitosan was added and stirred for another 20 minutes at a stirring speed of 50 to 60 rpm. Pass the treatment solution through a 0.3 μm microporous filter to obtain a microfiltrate. After the filtration, the filter residue in the filter was replaced twice with 40°C deionized water, each time with 500 mL of water. At this time, the filtrate was about 1940 mL, and the filter residue contained about 60 mL of replacement liquid. The filtrate enters a tubular ultrafilter with a diameter of 100 mm for ultrafiltration. The molecular weight of the ultrafilter membrane is 1000 Daltons, the operating pressure is 0.2 MPa, the operating temperature is 40 ° C, and the membrane...

Embodiment 2

[0025] Take 1000 mL of biological fermentation broth of dodecanedioic acid, add 30 g of activated carbon at 80° C. for decolorization, stir, and filter to obtain a filtrate. The temperature of the filtrate was kept at 40° C., 7 mg of ethylenediamine tetraacetic acid was added, and stirred for 20 minutes, and then 11 mg of chitosan was added, and stirred for another 20 minutes at a stirring speed of 50 to 60 rpm. Pass the treated solution through a 0.1 μm microporous filter for microfiltration. After the filtration, the filter residue in the filter was replaced twice with 40°C deionized water, each time with 500 mL of water, and the filtrate was about 1940 mL at this time. The filtrate enters into a plate type ultrafilter for ultrafiltration, the molecular weight of the ultrafilter membrane is 1000 Dalton, the operating pressure is 0.2MPa, the operating temperature is 40°C, and the membrane surface velocity is 2.0m / s. At the end of the ultrafiltration, about 1900 mL of the ult...

Embodiment 3

[0027] In addition to adding chitosan 5mg and ethylenediaminetetraacetic acid 10mg when the filtrate temperature is 30°C, the molecular weight of the ultrafilter membrane is 500 Daltons, the operating pressure is 0.02MPa, the operating temperature is 30°C, and the membrane surface velocity is 1.2m / s, the ultrafiltration permeate was used to precipitate dodecanedioic acid with hydrochloric acid, and the filter cake was washed 4 times with deionized water at about 60°C. The rest of the operations were the same as in Example 2, and the product of dodecanedioic acid was obtained after drying 46.84g, analysis, total acid 99.64% in this product, monoacid (dodecanedioic acid) 98.40%, nitrogen content 50ppm, Fe 2+ 3ppm, ash 100ppm.

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Abstract

The separation and purification method of dodecanedioic acid includes the following steps: decolouring the fermenting liquor in which the organism is fermented with active carbon, filtering, adding chitosan and ethylene diamine tetraacetic acid into the filtrate, making them combine with impurity being in fermenting liquor to form suspended matter, microfiltering to remove the suspended matter, ultrafiltering and further removing impurity to make purification, then adding acid in the filtrate to make dodecanedioic acid precipitate, filtering and drying so as to obtain the dodecanedioic acid product.

Description

1. Technical field [0001] The invention relates to a method for separating and purifying dodecanedioic acid, more precisely, to a method for separating and purifying dodecanedioic acid produced by fermentation. 2. Background technology [0002] Dodecanedioie Acid (DDDA for short), also known as lauric acid, is an important chemical raw material for the manufacture of engineering plastics, nylon 12, nylon hot-melt adhesives, spices, coatings, optical cables, etc., and has a wide range of uses. The production of dodecanedioic acid generally has two methods: chemical synthesis and biological fermentation. However, due to the chemical synthesis method, the hydrogenation reaction needs to be fire-proof, explosion-proof, and poison-proof, and it must be catalytically synthesized under high temperature and high pressure conditions. Severe environmental pollution and high production costs have limited its industrial application. In recent years, the industrial production of dodecan...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C51/42C07C51/487C07C55/21
Inventor 章序文李育炜何建铧王晨
Owner SHANGHAI RES INST OF CHEM IND
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