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Antimicrobial composition

A composition, compound technology, applied in the direction of chemicals for biological control, biocides, animal repellants, etc., can solve the problem of alternatives reducing the risk of microbial resistance development, insensitivity to antimicrobial compounds, etc.

Active Publication Date: 2022-07-29
FIRMENICH SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Without wishing to be bound by any particular theory, the availability of alternatives reduces the risk of development of microbial resistance and / or insensitivity to specific antimicrobial compounds

Method used

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  • Antimicrobial composition
  • Antimicrobial composition
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0170] Measurement of antimicrobial activity of compositions according to the invention

[0171] Methods for Assessing Antimicrobial Activity

[0172] The following methods allow for a combined assessment of the antimicrobial activity of different raw materials. The fractional inhibitory concentration index (FIC index) is a measure of activity (Garcia L.S., Clinical Microbiology Procedures Handbook, pg. 140-162, 3 rd Edition (2010), ASM Press, Washington DC), and calculated according to the following formula:

[0173]

[0174] of which (MIC A individually) and (MIC B alone) are the minimum inhibitory concentrations (MIC) of components A and B when used alone; while (MIC A combination) and (MIC B combination) is the minimum inhibitory concentration of materials A and B when tested in combination. Component A corresponds to non-2,6-dien-1-ol and component B represents 3-neopentylpyridine, 2-methylhex-3-one oxime, terpineol or 2-isopropyl-5- methylphenol.

[0175]...

Embodiment 2

[0221] Antimicrobial Effects of Compositions According to Some Forms Provided herein in Liquid Soap Bases

[0222] Preparation of bacterial solutions

[0223] Bacterial solutions of the two strains E. coli DSMZ 1103 and S. aureus DSMZ 1104 were prepared for BCT testing as follows. Stock cultures stored at -80°C were subcultured on Tryptic Soy Agar (TSA) agar plates and incubated at 37°C for 24 hours to obtain single colonies. Single colonies of primary cultures were streaked onto TSA slants and incubated in a 37°C incubator for 24 hours. Collect bacterial plateaus of slant cultures in PBS buffer to prepare target levels of 1–5 × 10 8 CFU / mL suspension. A 1:100 dilution of each cell suspension in PBS buffer was used as the bacterial solution for the BCT test.

[0224] Preparation of test samples

[0225] Test samples of bases with synergistic binary mixtures were prepared as follows. The raw materials of the synergistic binary mixture (Table 17) were mixed with the ...

Embodiment 3

[0243] Antibacterial effect of compositions according to some forms provided herein in roll-on deodorant bases

[0244] Preparation of bacterial solutions

[0245]A bacterial solution of C. xerosis ATCC 373 strain was prepared for BCT testing as follows. Stock cultures stored at -80°C were subcultured on tryptic soy agar medium containing 0.5% Tween 80 (TSA-TW80) and incubated at 37°C for 48 hours. Primary cultures were subcultured onto TSA-TW80 again to prepare secondary cultures. A single colony of the secondary culture was inoculated into 30 ml of brain heart infusion (BHI) broth (BHI-TW80) containing 0.5% Tween 80 and incubated at 37°C for 24 hours at 180 rpm. An aliquot (1 ml) of the 24 hour culture was inoculated into 30 ml of fresh BHI-TW80 broth and incubated for 48 hours at 37°C at 180 rpm. Aliquots (2-3 ml) of the 48 hour culture were inoculated into four 50 ml fresh BHI-TW80 broth media and incubated at 37°C at 180 rpm for 4-6 hours. When the OD reached the ...

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Abstract

The present disclosure relates to the field of antimicrobial compositions. More specifically, the present invention relates to the use of a composition comprising a component selected from the group consisting of (i) nonyl-2, 6-dien-1-ol and at least one component selected from the group consisting of 3-neopentylpyridine, 2-methylhex-3-ketoxime, terpilenol, and 2-isopropyl-5-methylphenol, as an antimicrobial agent, and to the use of a composition comprising a component selected from the group consisting of: (i) nonyl-2, 6-dien-1-ol and at least one component selected from the group consisting of 3-neopentylpyridine, 2-methylhex-3-ketoxime, terpilenol, and 2-isopropyl-5-methylphenol; (ii) at least one component selected from the group consisting of [gamma]-dodecalactone, 1-methyl-4-(1-methylvinyl)-cyclohexene, 4-methoxybenzaldehyde, and 1, 3-benzodioxol-5-formaldehyde, and at least one component selected from the group consisting of [gamma]-dodecalactone, 1-methyl-4-(1-methylvinyl)-cyclohexene, 4-methoxybenzaldehyde, and 1, 3-benzodioxol-5-formaldehyde; (iii) (Z)-3, 7-dimethyl-2, 6-octadiene-1-ol, and [gamma]-dodecalactone, and a method for preparing the same; (iv) cis-4-(isopropyl) cyclohexane methanol and 4-methoxybenzaldehyde, and (v) an organic solvent; and (v) 1, 3-benzodioxol-5-formaldehyde and 4-methoxybenzaldehyde, where the ingredient is present in an amount sufficient to provide an antimicrobial effect. The composition and its use for the preparation of antimicrobial active perfuming compositions and consumer products are also an object of the invention.

Description

[0001] The present invention is a divisional application of the invention patent application No. 201780047414.1 filed on August 4, 2017 with the name of the invention "antimicrobial composition". [0002] Cross-reference related applications [0003] This application claims priority to US Provisional Patent Application Serial No. 62 / 371,462, filed August 5, 2016, and European Patent Application Serial No. 16186681.9, filed August 31, 2016, the entire contents of which are incorporated herein by reference. technical field [0004] The present disclosure relates to the field of antimicrobial compositions and their use as antimicrobial agents, or their use in the preparation of antimicrobially active perfuming compositions and consumer products. More specifically, the present disclosure relates to a composition selected from the group consisting of: (i) non-2,6-dien-1-ol and a composition selected from the group consisting of 3-neopentylpyridine, 2-methyl At least one component ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N27/00A01N31/02A01N31/04A01N31/08A01N35/04A01N35/10A01N43/08A01N43/30A01N43/40A01P1/00A61K8/31A61K8/34A61K8/35A61K8/40A61K8/41A61K8/49A61Q17/00
CPCA01N31/02A01N43/08A01N35/04A01N27/00A01N31/04A01N31/08A01N35/10A01N43/30A01N43/40A61K8/31A61K8/34A61K8/345A61K8/342A61K8/347A61K8/35A61K8/40A61K8/41A61K8/4926A61K8/4973A61Q17/005A61L9/01A61K8/33A61Q19/10A61K8/49A61K2800/56A61K2800/77A61Q13/00
Inventor M·班德拉N·奥利利G·马尔
Owner FIRMENICH SA
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