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Preparation method of injectable photocuring hemostatic hydrogel for traumatic brain injury

A brain injury, traumatic technology, applied in application, surgery, surgical adhesives, etc., can solve the problems of unable to achieve sustained release, unable to adapt to complex hemostatic environment, etc., achieve controllable mechanical properties, is conducive to hemostasis repair, good stability sexual effect

Pending Publication Date: 2022-07-22
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the above-mentioned technical problems, the present invention provides a preparation method for injectable photocurable hemostatic hydrogel for traumatic brain injury, to obtain a convenient hydrogel for hemostasis, so as to solve the problem that the above-mentioned traditional hemostatic materials cannot adapt to complex hemostatic environments and the problem of not being able to achieve sustained release

Method used

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  • Preparation method of injectable photocuring hemostatic hydrogel for traumatic brain injury
  • Preparation method of injectable photocuring hemostatic hydrogel for traumatic brain injury
  • Preparation method of injectable photocuring hemostatic hydrogel for traumatic brain injury

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Embodiment 1

[0037] Practical application of the preparation method of injectable photocurable hemostatic hydrogel for traumatic brain injury:

[0038] (1) adding sodium carbonate to deionized water, diluting the sodium carbonate solution to pH=9, then adding hyaluronic acid at a ratio of 20 g / L, then stirring and dissolving at 50 ° C to obtain a hyaluronic acid solution, methyl The volume-to-mass ratio of acrylic anhydride and hyaluronic acid is 3:1, the N,N-dimethylformamide added at the ratio of 3ml / L, triethylamine is added at the ratio of 0.2g / L, and the ratio is 1.0 every 12 hours. Sodium carbonate was added at a ratio of mmol / L, and after 24 hours of reaction at room temperature, dialysis was performed with deionized water at room temperature for 5 days, and the water was changed every 12 hours. The molecular weight cut-off of the dialysis bag was: 8KDa-14KDa. methacrylated hyaluronic acid;

[0039] (2) An ethanol-water solution with a volume ratio of 100 ml / L was prepared, and NaO...

Embodiment 2

[0043] Practical application of the preparation method of injectable photocurable hemostatic hydrogel for traumatic brain injury:

[0044] (1) adding sodium carbonate to deionized water, diluting the sodium carbonate solution to pH=10, then adding hyaluronic acid in a ratio of 5g / L, then stirring and dissolving at 30°C to obtain a hyaluronic acid solution, methyl The volume-to-mass ratio of acrylic anhydride and hyaluronic acid is 5:1, the N,N-dimethylformamide added at the ratio of 5ml / L, triethylamine at the ratio of 0.6g / L, and the ratio of 0.8 every 12 hours. Sodium carbonate was added at a ratio of mmol / L, and after 40 hours of reaction at room temperature, dialysis was performed with deionized water at room temperature for 5 days, and the water was changed every 12 hours. The molecular weight cut-off of the dialysis bag was: 8KDa-14KDa. methacrylated hyaluronic acid;

[0045] (2) Prepare an ethanol-aqueous solution with a volume ratio of 750ml / L, and NaOH is added to th...

Embodiment 3

[0049] This embodiment is an experimental case using the preparation method of an injectable photocurable hemostatic hydrogel for traumatic brain injury;

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Abstract

The invention discloses a preparation method of injectable light-cured hemostatic hydrogel for traumatic brain injury, which comprises the following steps: by taking hyaluronic acid as a raw material, carrying out acylation modification on the hyaluronic acid by utilizing methacrylic anhydride, and introducing photo-crosslinking to obtain cross-linked network hydrogel; photocrosslinking is adopted, an activated network is generated for natural polymer hydrogel, the grafting rate of methylacryloylated HAMA is controlled according to the amount of methacrylic anhydride, an injectable gel material with the controllable degradation rate and enhanced mechanical property is obtained, and then oxidized cellulose is combined, so that the free radical oxidation resistance of the injectable gel material is higher; compared with the prior art, the injectable hydrogel has the advantages that the injectable hydrogel is more smooth, higher in slow-release efficiency, more beneficial to hemostasis and repair and excellent in mechanical property and biocompatibility, and in addition, the injectable photo-curing hydrogel is bonded with the synthetic fiber cell growth factor and the cyclosporin A, so that the injectable hydrogel has the functions of resisting inflammation and promoting tissue repair, and development and utilization of injectable functional hydrogel materials are facilitated.

Description

technical field [0001] The invention belongs to the technical field of biological material preparation, in particular to a preparation method of an injectable light-cured hemostatic hydrogel for traumatic brain injury. Background technique [0002] Traumatic brain injury is a mechanical damage to the brain tissue caused by strong external force, usually accompanied by intracranial hemorrhage caused by rupture of cerebral blood vessels. If not dealt with in time, headache, vomiting, partial weakness or numbness may occur in a short period of time, followed by coma. Severe traumatic brain injury is usually accompanied by symptoms such as hemiplegia, which is related to the lack of effective treatment to suppress intracranial hemorrhage in the early stage after trauma. Therefore, timely resolution of intracranial hemorrhage is more important after traumatic brain injury. [0003] Appropriate hemostatic materials can significantly shorten the operative time and are essential f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/28C08J3/24C08L1/28C08L5/08C08B37/08A61L24/00A61L24/08
CPCC08J3/075C08J3/28C08J3/24C08B37/0072A61L24/0042A61L24/0031A61L24/001A61L24/08A61L24/0015A61L2400/04A61L2400/06A61L2300/414A61L2300/41A61L2300/252A61L2300/602C08J2301/28C08J2405/08C08J2305/08C08J2401/28C08L5/08C08L1/04
Inventor 魏景宽张磊申佳宁李勇李宁潘扬萍
Owner KUNMING UNIV OF SCI & TECH
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