Double capsule for the administration of active principles in multiple therepies

A technology of capsules and compounds, applied in the field of double-layer capsules that give active ingredients in compound treatments, can solve problems such as unfavorable treatment results

Inactive Publication Date: 2004-04-28
APTALIS PHARMA CANADA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Therefore, it is safe to say that misinterpretation of treatments that require complex doses such as combination therapy may detrimentally affect the outcome of the treatment itself

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0125] Prepare size 3 capsules with the following contents:

[0126] Tetracycline hydrochloride 125mg

[0127] Omeprazole for Stomach Protection 5mg

[0128] Magnesium Stearate 5mg

[0129] Talc powder 5mg

[0130] Prepare size O+ capsules with the following contents:

[0131] Bismuth dicalcium citrate 215mg (equivalent to 53.7mg bismuth)

[0132] Metronidazole 125mg

[0133] Magnesium Stearate 5mg

[0134] Talc powder 5mg

[0135] Capsules O+ were not fully sealed so that they could be reopened with a hand machine (Zuma) and inserted into pre-prepared size 3 capsules.

[0136] Capsules were then sealed and subjected to controls related to deagglomeration time, average weight of contents, sealing process, single component evaluation and microbial purity as described in the Pharmacopoeia.

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PUM

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Abstract

A pharmaceutical dosage form particularly suitable for the administration of active principles in multiple therapies is disclosed. The pharmaceutical dosage form is a double capsule wherein an internal capsule is placed inside an external one. Each internal and external capsule includes one or more active principles. A double capsule according to the invention is preferably used in triple or quadruple therapies against the microorganisms Helicobacter Pylori. Advantages of this pharmaceutical dosage form consist in provididng a simple posology for administration of two and more active principles, allowing the active principles to activate at the right intervals of time and in the pre-established quantities, and preventing interactions between active principles. In a preferred embodiment of the invention, the pharmaceutical dosage form has an external capsule containing bismuth subcitrate and metronidazole, and an internal capsule containing tetracycline and optionally omeprazole, which is used in therapy for eradication of Helicobacter pylori.

Description

field of invention [0001] The present invention relates to a pharmaceutical dosage form consisting of double capsules for administering active ingredients in combination therapy. The bilayer capsule consists of a capsule placed inside another capsule. Background of the invention [0002] Therapies for the administration of more than one active ingredient simultaneously or at short intervals are well known. The most commonly used pharmaceutical dosage form consists of tablets with coatings to allow separate release of the compounds for the different active ingredients. [0003] Among the treatments described, the most common are effects on the digestive system due to the presence of the microorganism Helicobacter pylori, such as gastritis and gastroduodenal ulcers, which may in due course lead to tumor formation. Helicobacter pylori is known as the newest name for Campylobacter pylori. [0004] US5196205 describes a method of treating these pathological agents comprising a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K9/64A61K31/19A61K31/4164A61K31/426A61K31/4439A61K31/60A61K31/65A61K31/7048A61K33/24A61K47/02A61K47/10A61K47/12A61K47/14A61K47/26A61K47/36A61K47/38A61K47/44A61P31/04
CPCA61K9/4808A61P1/04A61P31/04A61K9/48
Inventor G·桑索
Owner APTALIS PHARMA CANADA
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