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Quantitative collection, treatment and preservation device and method for liquid sample

A liquid sample and quantitative collection technology, which is applied in the field of sample collection, processing and storage in analytical chemistry, can solve the problems of cumbersome sample processing, difficult sample quantitative measurement, inconvenient storage, etc., and achieves convenient operation, low cost, and simple structure. Effect

Pending Publication Date: 2022-06-07
ZHEJIANG UNIV HANGZHOU GLOBAL SCI & TECH INNOVATION CENT +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention uses a microchannel network to quantitatively measure samples, and the present invention can generate multiple samples with accurate volumes in one collection process, which solves the problem of difficulty in quantitatively measuring samples due to small sample volumes in the conventional micro-sampling process
By using a porous material chip with a sample processing function to store samples, the invention solves the problems of cumbersome sample processing and inconvenient storage when sampling under non-professional conditions or in the field

Method used

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  • Quantitative collection, treatment and preservation device and method for liquid sample
  • Quantitative collection, treatment and preservation device and method for liquid sample
  • Quantitative collection, treatment and preservation device and method for liquid sample

Examples

Experimental program
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Effect test

Embodiment 1

[0082] The present invention is applied to the on-site blood sample collection and preservation of athlete doping detection, such as Figures 2 to 4 shown.

[0083] In Example 1, the material of the quantitative measuring chip 1 is polymethyl methacrylate, and the quantitative measuring chip 1 has a microchannel network 2 on it. The microchannel network has one inlet 3 and three outlets 4, and each outlet 4 has a corresponding microchannel 8 with a volume of 20 μL.

[0084] In Example 1, the inlets 3 of the microchannel network 2 have some hydrophobic treated surfaces 12. like image 3 As shown, these hydrophobic treatment surfaces 12 enable the liquid sample to be separated from the inlet 3 at the inlet 3 to automatically block and separate the liquid between the microchannels 8 .

[0085] In Example 1, the microchannel 8 is closed, and the inner surfaces of the microchannel 8 and the outlet 4 are both subjected to surface hydrophilic treatment.

[0086] In Example 1, the...

Embodiment 2

[0095] The present invention is applied to the collection of urine samples, such as Figure 5 shown.

[0096] In Example 2, the porous material chip 5 is made of cellulose filter paper, and a processing and storage unit 6 having a hydrophilic channel is formed by spraying wax. The specific antibody 11 is embedded on the processing and storage unit 6 as a sample processing material. When the urine sample diffuses from the microchannel outlet 4 at the corresponding position 10 of the porous material chip 5 to other positions of the hydrophilic channel of the processing and storage unit 6 , the trace antigens in the urine sample can be captured by the specific antibody 11, thereby realizing the enrichment of trace antigens in the urine.

[0097] In Example 2, the processing and storage unit 6 is also loaded with anhydrous magnesium sulfate as a sample processing material, which facilitates rapid drying and long-term storage of the sample.

Embodiment 3

[0099] The invention is applied to the detection of toxins in algal blooms by collecting environmental water samples.

[0100] In Example 3, the microchannels 8 in the microchannel network 2 are not closed, but open, so that large particles of impurities in the process of collecting environmental water samples can block the microchannels and cause sampling failure.

[0101] In Example 3, the porous material chip 5 is made of sintered polyethylene that has undergone hydrophilic treatment, so as to ensure that the porous material chip can withstand environmental water samples with complex compositions.

[0102] In Example 3, the sample treatment material contained two substances, sodium benzoate and anhydrous magnesium sulfate. Sodium benzoate can quench the microbial activity in the water sample as soon as possible to avoid the deterioration of the sample during the preservation process; and anhydrous magnesium sulfate can realize the dry preservation of the sample.

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Abstract

The invention discloses a device and a method for quantitatively collecting, processing and storing a liquid sample. The device comprises a quantitative measuring chip and a porous material chip connected with the quantitative measuring chip through a structural member, the quantitative measuring chip is provided with a micro-channel network with an inlet and a plurality of outlets; the porous material chip is provided with a plurality of processing and storing units which are in butt joint with the outlets in the folding working state. The device provided by the invention can be used for quantitatively measuring liquid samples from nano liters to milliliters. According to the invention, collection, treatment and preservation of the liquid sample are combined, and after collection of the liquid sample is completed, post-treatment such as antibiosis, drying, enrichment and the like is carried out immediately, so that the sample can be preserved on the porous material chip for a long time, and collection, treatment and preservation of the liquid sample are greatly facilitated. The device is simple in structure and convenient to operate, and can still keep reliable performance under non-professional conditions or field conditions.

Description

technical field [0001] The invention relates to the field of sample collection, processing and preservation of analytical chemistry, in particular to a quantitative acquisition, processing and preservation device for liquid samples and a method thereof. Background technique [0002] Sample collection is usually referred to as sampling, which is a method of sampling. Sampling of liquids is the first task of many research and analysis, such as blood testing, urine testing, water quality testing, chemical experimental analysis, radioactivity testing, and liquid composition analysis. Wait. [0003] At present, most of the sampling of liquid samples requires manual direct operation and the use of corresponding measuring devices, such as common devices such as pipettes, pipettes, and liquid samplers. When the number of samples is small and the sampling volume is suitable, it is feasible to use a universal measuring tool for sampling. However, when the liquid volume is small, for...

Claims

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Application Information

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IPC IPC(8): G01N1/10G01N1/28
CPCG01N1/10G01N1/28
Inventor 方群王慧峰潘建章陈志宇温洪涛
Owner ZHEJIANG UNIV HANGZHOU GLOBAL SCI & TECH INNOVATION CENT
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