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Phenylethyl resorcinol nanostructure lipid carrier, preparation method and application in cosmetics

A technology of phenylethylresorcinol and nanostructured lipids, applied in preparation methods and applications in cosmetics, in the field of phenylethylresorcinol nanostructured lipid carriers, can solve polymorphic transformation, drug Leakage and other issues to achieve the effect of reducing irritation, avoiding toxic effects, improving photostability and bioavailability

Active Publication Date: 2022-05-20
OCEAN UNIV OF CHINA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Solid lipid nanoparticles (SLN) are mainly composed of solid lipids, which can enhance the stability of active ingredients, but are prone to polymorphic transformation during storage, leading to drug leakage

Method used

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  • Phenylethyl resorcinol nanostructure lipid carrier, preparation method and application in cosmetics
  • Phenylethyl resorcinol nanostructure lipid carrier, preparation method and application in cosmetics
  • Phenylethyl resorcinol nanostructure lipid carrier, preparation method and application in cosmetics

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Embodiment Construction

[0060] 1. Materials and Reagents

[0061] The experimental methods used in the following examples, unless otherwise specified, are conventional methods; the reagents, materials, instruments, etc. used in the following examples, unless otherwise specified, can be obtained from commercial sources.

[0062] White oil, olive oil are cosmetic grade, come from Sigma company;

[0063] Oleic acid and oleic acid macrogol glyceride are cosmetic grade, from France Garfars;

[0064] Castor oil polyoxyl ester, isooctyl palmitate, ethylhexyl palmitate, and caprylic triglyceride are cosmetic grades from BASF, Germany;

[0065] Isononyl isononanoate is cosmetic grade, from Nissin, Japan;

[0066] Soy lecithin is cosmetic grade, from Cargill Bio;

[0067] Beeswax is cosmetic grade, from Suzhou Yushiji Biotechnology Co., Ltd.;

[0068] Phenylethyl resorcinol is cosmetic grade, from Japan TCI;

[0069] Insect white wax is cosmetic grade, from Suzhou Yushiji Biotechnology Co., Ltd.;

[0070...

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Abstract

The invention discloses a phenethyl resorcinol nano-structure lipid carrier, a preparation method and application of the phenethyl resorcinol nano-structure lipid carrier in cosmetics. The nanostructure lipid carrier comprises the following components in percentage by mass: 0.1%-2% of mixed lipid, 0.1%-2% of a surfactant and the balance of a carrier, the content of the mixed emulsifier is 1%-4%; and the balance of water. The nano-structure lipid carrier effectively improves the stability and encapsulation efficiency of active substances, has a slow release effect, is easy to prepare on a large scale, and has a better application prospect in the field of cosmetics.

Description

technical field [0001] The invention relates to a nano-lipid carrier, in particular to a phenylethyl resorcinol nano-structured lipid carrier, a preparation method and an application in cosmetics. Background technique [0002] As a functional raw material of cosmetics, whitening agent has received great attention. Its development and application research have been deepened continuously, and high-efficiency raw materials on the market have been continuously updated. As one of the current mainstream whitening agents, phenylethyl resorcinol (PR) mainly reduces the content of melanin by inhibiting the activity of tyrosinase. It is quicker than kojic acid and more in line with the needs of consumers. However, its poor water solubility and instability when exposed to light limit its application in whitening products, so it is necessary to wrap it with an appropriate delivery system to improve its photostability and solubility; and the natural barrier of the skin is to a large exte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/92A61K8/14A61K8/34A61K8/37A61K8/55A61Q19/02
CPCA61K8/347A61K8/14A61K8/927A61K8/37A61K8/922A61K8/553A61Q19/02A61K2800/782A61K2800/56
Inventor 刘晨光杨莹于钰孙茜丁松李军
Owner OCEAN UNIV OF CHINA
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