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Layered super-hydrophilic Ti-Cu-MOFs as well as preparation method and application thereof

A ti-cu-mofs, super-hydrophilic technology, applied in chemical instruments and methods, other chemical processes, etc., can solve the problem of affecting the separation and purification performance of MOFs, preparation methods and reaction conditions affecting the morphology, crystal structure and pores of MOFs efficiency and other issues, to achieve the effects of saving pretreatment time and cost, controllable morphology and structure, and high adsorption capacity

Active Publication Date: 2022-05-13
ZHEJIANG SHUREN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004]The structure of MOFs is closely related to the type of metal atoms, organic ligands and / or targeting agents, and its preparation method and reaction conditions will also affect the shape of MOFs. appearance, crystal structure and porosity, and then affect the separation and purification performance of MOFs

Method used

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  • Layered super-hydrophilic Ti-Cu-MOFs as well as preparation method and application thereof
  • Layered super-hydrophilic Ti-Cu-MOFs as well as preparation method and application thereof
  • Layered super-hydrophilic Ti-Cu-MOFs as well as preparation method and application thereof

Examples

Experimental program
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preparation example Construction

[0025] The invention provides a method for preparing layered superhydrophilic Ti-Cu-MOFs, comprising the following steps:

[0026] mixing the copper source, the rigid aromatic amine ligand, the stabilizer and water, and performing the first solvothermal reaction to obtain the intermediate;

[0027] The intermediate is mixed with a titanium source and an organic solvent for a second solvothermal reaction to obtain layered superhydrophilic Ti-Cu-MOFs.

[0028] The invention mixes the copper source, the rigid aromatic amine ligand, the stabilizer and water, and performs the first solvothermal reaction to obtain the intermediate. In the present invention, the copper source is preferably a copper salt, more preferably at least one of copper acetate and copper nitrate; the rigid aromatic amine ligand preferably includes 4,4'-diamino-terphenyl and tri( At least one of 4-aminophenyl)amine; said stabilizer preferably includes at least one of sulfamic acid and p-aminobenzoic acid. In ...

Embodiment 1～9

[0042] (1) Add copper source, rigid aromatic amine ligand, stabilizer and 30mL pure water into a polytetrafluoroethylene thick-walled pressure-resistant bottle, seal it with a polytetrafluoroethylene screw plug, and ultrasonically disperse for 30 minutes;

[0043] (2) Transfer the polytetrafluoroethylene thick-walled pressure-resistant bottle described in step (1) to a microwave reactor, set the reaction temperature to 180° C., and perform solvothermal reaction at this temperature for 24 hours;

[0044] (3) After the solvothermal reaction in step (2) is completed, naturally cool to room temperature, collect the filter residue by vacuum filtration, rinse the filter residue with water, methanol, and acetone in sequence, and dry it in vacuum at 60°C for 12 hours;

[0045] (4) Add the product obtained in step (3) into a polytetrafluoroethylene thick-walled pressure-resistant bottle, then add 15mL N,N-dimethylformamide and titanium source in sequence, seal it with a polytetrafluoroe...

Embodiment 1

[0052] The transmission electron micrographs and scanning electron micrographs of the layered superhydrophilic Ti-Cu-MOFs prepared in Example 1 are as follows: figure 1 with figure 2 shown. Depend on figure 1 It can be seen that the layered superhydrophilic Ti-Cu-MOFs prepared by the present invention have regular morphology and present an obvious lamellar structure, which is characterized by figure 2 The scanning electron microscopy characterization results were further confirmed.

[0053] The layered superhydrophilic Ti-Cu-MOFs prepared in Examples 2-9 are similar in appearance to the layered superhydrophilic Ti-Cu-MOFs prepared in Example 1, and the surface is rich in hydroxyl groups. The layered superhydrophilic Ti-Cu-MOFs prepared in Examples 2-9 have a high adsorption capacity for phospholipid co-extraction in clinical biological samples, and thus can achieve efficient separation and purification of complex matrices in clinical biological samples.

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Abstract

The invention provides layered super-hydrophilic Ti-Cu-MOFs as well as a preparation method and application thereof, and relates to the technical field of composite materials. According to the invention, copper ions and titanium ions are taken as bimetallic centers and are subjected to a coordination reaction with rigid aromatic amine ligands, so that layered super-hydrophilic Ti-Cu-MOFs with a lamellar structure are efficiently synthesized. Compared with the prior art, the preparation method is simple, the morphology and the structure are controllable, the surface of the prepared layered super-hydrophilic Ti-Cu-MOFs has rich hydroxyl groups, and the prepared layered super-hydrophilic Ti-Cu-MOFs has high adsorption capacity on phospholipid co-extracts in clinical biological samples; the method can be used for analyzing phenothiazine drugs and metabolites thereof in biological samples and realizing one-step separation and purification, so that the pretreatment efficiency of clinical biological samples is greatly improved, and the analysis time is shortened.

Description

technical field [0001] The invention relates to the technical field of composite materials, in particular to a layered superhydrophilic Ti-Cu-MOFs and its preparation method and application. Background technique [0002] Phenothiazines are a class of typical antipsychotic drugs, which have a good therapeutic effect in clinical practice. However, cases of poisoning or even death due to overdose or misuse occur from time to time. Since this type of drug is easily metabolized in the body, the content of the original drug in the body is very small. Therefore, it is of great practical significance to establish a simple, rapid and sensitive method for the detection of phenothiazines and their metabolites in plasma. In recent years, with the development of mass spectrometry, liquid chromatography tandem mass spectrometry has become a common method for the detection of phenothiazine drug residues in clinical biological samples. At the same time, in order to meet the requirements o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G83/00B01J20/281
CPCC08G83/008B01J20/281C07F7/28B01J20/3078B01J20/226C07F1/08B01J2220/48
Inventor 陆胤赵永纲雷超叶明立塔兹娅娜·萨维斯卡娅安德烈·伊万尼茨
Owner ZHEJIANG SHUREN UNIV
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