Preparation process and quality control method of inula and ochre soup formula granules

Pending Publication Date: 2022-05-06
SICHUAN NEO GREEN PHARMA TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at present, there are few research reports on its preparation and quality control, so the modern preparation and quality control of Xuanfu Daizhe Decoction are investigated and studied

Method used

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  • Preparation process and quality control method of inula and ochre soup formula granules
  • Preparation process and quality control method of inula and ochre soup formula granules
  • Preparation process and quality control method of inula and ochre soup formula granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] This example is a preparation process of the formula granules of Xuanfu Daizhe Decoction.

[0090] Raw material formula: Inula 5.0kg, ginseng 3.3kg, ginger 8.4kg, ocher 1.7kg, licorice 5.0kg, pinellia 5.0kg, jujube 5.0kg.

[0091] Preparation process: add water to decoct three times, add 8 times the amount of water to the first decoction, soak for 0.5 hours, and extract for 1 hour; add 8 times the amount of water to the second decoction, extract for 1 hour; liquid, stand still, 4000r / min centrifugal filtration, the filtered water extract is concentrated under reduced pressure to a clear paste with a relative density of 1.05, and mixed evenly. Spray drying at a temperature of 80°C and a feeding speed of 0.4R / min. After adding dextrin, the weight ratio of dextrin to clear paste is 1:2, granulate, and dry below 60°C to make 10kg spin-coated Daizhe soup formula granules.

Embodiment 2

[0093] Raw material formula: Inula 5.0kg, ginseng 3.3kg, ginger 8.4kg, ocher 1.7kg, licorice 5.0kg, pinellia 5.0kg, jujube 5.0kg.

[0094] Preparation process: add water to decoct three times, add 8 times the amount of water to the first decoction, soak for 0.5 hours, and extract for 1 hour; add 8 times the amount of water to the second decoction, extract for 1 hour; solution, let it stand, 4000r / min centrifugal filtration, the filtered water extract is concentrated under reduced pressure to a clear paste with a relative density of 1.05, mixed evenly, when the feed temperature is 55°C, the inlet air temperature is 200°C, and the air outlet Spray drying at a temperature of 100°C and a feeding speed of 0.6 R / min. After adding lactose, the weight ratio of lactose to clear paste is 1:5, granulate, and dry below 60°C to make 10kg of spin-coated ocher soup Formula granules.

Embodiment 3

[0096] Raw material formula: Inula 5.0kg, ginseng 3.3kg, ginger 8.4kg, ocher 1.7kg, licorice 5.0kg, pinellia 5.0kg, jujube 5.0kg.

[0097] Preparation process: add water to decoct three times, add 8 times the amount of water to the first decoction, soak for 0.5 hours, and extract for 1 hour; add 8 times the amount of water to the second decoction, extract for 1 hour; liquid, stand still, 4000r / min centrifugal filtration, the filtered water extract is concentrated under reduced pressure to a clear paste with a relative density of 1.05, and mixed evenly. Spray drying at a temperature of 100°C and a feeding speed of 0.5 R / min. After adding dextrin, the weight ratio of dextrin to clear paste is 1:2, granulate, and dry below 60°C to make 10kg spin-coated Daizhe soup formula granules.

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Abstract

According to the preparation process and the quality control method, the total content of chlorogenic acid and caffeic acid and the total content of liquiritin and ammonium glycyrrhizinate in the inula type ochre soup are researched for the first time, the dry extract yield is combined, meanwhile, the dry extract yield is taken as main investigation indexes, and the inula type ochre soup formula granules are prepared. The process parameters and conditions of a water extraction process, a separation and purification process, a concentration process, a spray drying process, a forming process and the like in the preparation process of the inula flower and orange soup formula granules are respectively determined, and the preparation process of the inula flower and orange soup formula granules, which is stable and reliable in process operation, reasonable and feasible, is provided; in view of the quality of the finished product of the inula and ochre soup formula granules, the invention also establishes a comprehensive quality control method of high performance liquid chromatography and thin layer chromatography.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine formula granules, and specifically relates to a preparation process and a quality control method of Xuanfu Daizhe Tang formula granules. Background technique [0002] Xuanfu Daizhe Decoction comes from Article 161 of Zhang Zhongjing's "Treatise on Febrile Diseases" in the Eastern Han Dynasty: "Treatise fever sweating, if vomiting, after the solution, the heart is hard, and the qi cannot be eliminated, Xuanfu Daizhe Decoction is the main treatment." It is composed of three liang of inula, two liang of ginseng, one liang of ochre, roasted licorice, three liang, washed pinellia, half a liter, five liang of ginger, broken jujube, twelve pieces. The whole prescription has the effects of reducing phlegm, replenishing qi and harmonizing the stomach. It is a common prescription for treating stomach deficiency and phlegm blocking qi. It is mainly used for feeling of hard feeling under...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61K9/16A61P1/00A61P1/04A61P1/08G01N30/02G01N30/06G01N30/34G01N30/36G01N30/74G01N30/86G01N30/90G01N30/91G01N30/95A61K33/26
CPCA61K36/28A61K33/26A61K36/258A61K36/9068A61K36/8888A61K36/484A61K36/725A61K9/1652A61K9/1623A61P1/00A61P1/04A61P1/08G01N30/02G01N30/06G01N30/34G01N30/36G01N30/74G01N30/8679G01N30/90G01N30/95G01N30/91A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 周厚成胡昌江黄宇冯健戴德蓉钟磊周维
Owner SICHUAN NEO GREEN PHARMA TECH DEV
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