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Stabilizing composition containing hydroquinone or derivative thereof

A composition and derivative technology, which is applied in the direction of drug combination, effective ingredients of hydroxyl compounds, medical preparations containing active ingredients, etc., can solve the problems of hydroquinone irritation and instability, reduce toxicity and ensure stability , Increase the effect of storage stability

Pending Publication Date: 2022-05-03
LG HOUSEHOLD & HEALTH CARE LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Though can try to overcome any shortcoming of this hydroquinone, be difficult to satisfy above-mentioned two shortcoming simultaneously, i.e. the irritation and the instability of hydroquinone

Method used

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  • Stabilizing composition containing hydroquinone or derivative thereof
  • Stabilizing composition containing hydroquinone or derivative thereof
  • Stabilizing composition containing hydroquinone or derivative thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～5 and comparative example 1～6

[0035] Comparison of the degree of discoloration according to the ratio of two antioxidants in the composite composition of hydroquinone and metal oxide (calamine)

[0036] Examples 1-5 and Comparative Examples 1-6 were prepared and evaluated according to the composition shown in Table 1 below.

[0037] [Table 1]

[0038]

[0039] Specifically, it was prepared as follows. According to the ratios in Table 1 above, the hydrophilic solvent and antioxidants 1 and 2 were mixed at room temperature. While stirring at 3000 rpm with a homomixer (homomixer), calamine as a metal oxide was charged and dispersed. When the calamine was sufficiently uniformly dispersed by stirring for 15 minutes, hydroquinone was added and stirred at 3000 rpm for 5 minutes to completely dissolve.

[0040] The degree of discoloration is measured as follows. In order to confirm the storage stability of the composition in Table 1 above, it was stored at 50° C. for 4 weeks. Afterwards, 200 ul of the supe...

Embodiment 6～7 and comparative example 7～10

[0044] Comparison of the degree of discoloration according to the type of antioxidant in the composite composition of hydroquinone and metal oxide (calamine)

[0045] Examples 6-7 and Comparative Examples 7-10 were prepared and evaluated according to the compositions shown in Table 2 below. The preparation method and the discoloration measurement method are the same as those in the above-mentioned Examples 1-5.

[0046] [Table 2]

[0047]

[0048] The results are shown in Table 2 and figure 2 . In Examples 6 and 7, the degree of discoloration showed a low value of 2.1 or less. On the contrary, in Comparative Examples 7 to 10, the degree of discoloration was 16.3 or more, which was high. Therefore, as for the kind of antioxidant, only using the same kind as in Examples 6 and 7 can improve the storage stability of hydroquinone in the composite composition of metal oxide and hydroquinone.

Embodiment 6、8、9 and comparative example 11～15

[0050] Comparison of the degree of discoloration according to the kind of acid (acid) in the composite composition of hydroquinone and metal oxide (calamine)

[0051] Examples 6, 8, and 9 and Comparative Examples 11 to 15 were prepared and evaluated according to the compositions shown in Table 3 below. The preparation method and the discoloration measurement method are the same as those in the above-mentioned Examples 1-5.

[0052] [table 3]

[0053]

[0054] The results are shown in Table 3 and image 3 . As in Examples 6, 8 and 9, when the type of acid used as an antioxidant is a dibasic or tribasic carboxylic acid, the discoloration degree is lower than 2.4. However, when the same other acids as in Comparative Examples 11 to 15 were used, the degree of discoloration was 28.9 or higher, which was high. Therefore, the storage stability of hydroquinone in the composite composition of metal oxide and hydroquinone can be improved only by using dibasic or tribasic carboxyl...

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PUM

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Abstract

The present disclosure relates to a stabilized composition containing hydroquinone or a derivative thereof, and a composition for securing the stability of hydroquinone or a derivative thereof, in which hydroquinone or a derivative thereof is contained as a whitening active ingredient, and additionally contains a metal oxide (preferably zinc oxide (ZnO), calamine (Calamine), titanium dioxide (TIO2) or a mixture thereof) as an ingredient for improving skin irritation. In order to ensure this stability, the composition of the present disclosure comprises (i) sodium metasulfite, sodium bisulfite, or a mixture thereof, and (ii) a dicarboxylic acid, a tricarboxylic acid, or a mixture thereof.

Description

technical field [0001] The present disclosure relates to a composition which not only reduces skin irritation but also ensures the stability of hydroquinone or its derivatives while containing hydroquinone or its derivatives which are useful for skin whitening and the like. Background technique [0002] In order to prevent skin pigmentation, a method of inhibiting melanin production by blocking some processes in the melanin production process is utilized. As such whitening agents, ascorbic acid, arbutin, kojic acid, etc. have been used in cosmetics, but the whitening effect is not high. [0003] Hydroquinone or its derivatives are superior in whitening effect compared with the above-mentioned whitening ingredients. However, hydroquinone or its derivatives are easily discolored by oxidation by air, heat, and / or light, and may be toxic to melanin-producing cells when oxidized. Specifically, oxidized hydroquinone passes through p-benzoquinone to generate quinhydrone, which ar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/34A61K8/27A61K8/29A61K8/23A61K8/362A61Q19/02A61K31/05A61K33/30A61K33/24A61K47/02A61K47/12A61P17/00
CPCA61K8/347A61K8/27A61K8/29A61K8/23A61K8/362A61Q19/02A61K31/05A61K33/30A61K33/24A61K47/02A61K47/12A61P17/00A61K2800/522A61K2800/592A61K2300/00A61K8/34A61K8/35A61K8/365
Inventor 陆娜恩金米娜黄铉珉全胜贤卢曙薰
Owner LG HOUSEHOLD & HEALTH CARE LTD
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