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Experimental method for reducing blood sugar of BKS-DB diabetic mouse by using rhizoma polygonati solid beverage

A technology of solid beverages and diabetic rats, applied in pathology reference, drug reference, patient-specific data, etc., can solve the problems of lack of test data, inability to draw down-regulation effect of diabetes, etc., and achieve the effect of improving insulin resistance state

Pending Publication Date: 2022-04-22
康学春
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Problems solved by technology

[0003] However, there is currently a lack of specific and effective experimental data in clinical practice, and it is impossible to conclude which indicators of Polygonatum Solid Beverage have a down-regulation effect on diabetes, as well as which side effects and unfavorable factors

Method used

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  • Experimental method for reducing blood sugar of BKS-DB diabetic mouse by using rhizoma polygonati solid beverage

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Embodiment Construction

[0034] see figure 1 , in an embodiment of the present invention, an experimental method for the hypoglycemic effect of Polygonatum solid drink on BKS-DB diabetic model mice, comprising the following steps:

[0035] Preferably, the mice are male BKS-DB diabetic mice aged 7 weeks and weighing 35-40 g.

[0036] Priority, the sealwort solid drink low dose group, sealwort solid drink middle dose group and sealwort solid drink high dose group were given 12g / kg, 24g / kg and 48g / kg of the crude drug of sealwort solid drink respectively according to the body weight of the mice, and the positive group was given according to the weight of the mice. Mice were given 300 mg / kg of metformin orally, and the diabetic model group was given 300 mg / kg of normal saline according to the weight of mice.

[0037] Priority, insulin resistance index (HOMA-IR) = FBG (fasting blood glucose) × FIN (fasting insulin) / 22.51.

[0038] Preferably, the detection of glycosylated hemoglobin in step S4 includes...

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Abstract

The invention relates to the technical field of rhizoma polygonati solid beverages, and discloses an experimental method for reducing blood sugar of BKS-DB diabetic rats by using rhizoma polygonati solid beverages, and the experimental method comprises the following steps: S1, detecting the activity, hair gloss, food intake, water intake and physique weight of the rats; s2, detecting an insulin resistance index; s3, detecting biochemical indexes such as triglyceride, total cholesterol and high-density lipoprotein cholesterol; s4, observing the change of each group of tissues by using an upright microscope; and S5, carrying out glycosylated hemoglobin detection and glycosylated serum protein concentration detection. Experimental analysis is carried out on the body weight, food intake, water intake, blood glucose level, fasting insulin level, insulin resistance index and the like of BKS-DB diabetic mice, and the results show that the rhizoma polygonati solid beverage obviously reduces the fasting blood glucose level of the BKS-DB diabetic mice, improves the insulin resistance state, and has a significant effect on preventing and treating the BKS-DB diabetic mice. The rhizoma polygonati solid beverage has a down-regulating effect on blood lipid triglyceride and glycated serum protein, and has no obvious liver and kidney injury side effect due to drug intervention.

Description

technical field [0001] The invention relates to the technical field of Polygonatum solid beverage, in particular to an experimental method for lowering blood sugar in BKS-DB diabetic rats by Polygonatum solid beverage. Background technique [0002] Polygonatum solid drink is mainly composed of Polygonatum, corn silk, bitter melon and other medicines. It has the effects of nourishing qi and nourishing yin, lowering blood sugar and diuresis. It is often used clinically for diabetes, nephritis, edema, oliguria, hypertension and other diseases, and has good clinical curative effect. [0003] However, there is currently a lack of specific and effective experimental data clinically, and it is impossible to draw which indicators of Polygonatum solid beverage have a down-regulation effect on diabetes, and which side effects and unfavorable factors. Contents of the invention [0004] The purpose of the present invention is to provide an experimental method for lowering blood sugar ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H70/40G16H70/60G16H10/60
CPCG16H70/40G16H70/60G16H10/60
Inventor 康学春
Owner 康学春
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