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Chitosan oligosaccharide enteric capsule as well as preparation method and application thereof

A technology of enteric-coated capsules and chitosan oligosaccharides, which is applied in capsule delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., and can solve problems such as reduction, precipitation, and stratification of chitosan oligosaccharides

Active Publication Date: 2022-04-22
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the production of chitosan oligosaccharide preparations, phenomena such as layering, turbidity, precipitation, and uneven color are prone to occur, making the chitosan oligosaccharide preparations poor in stability; Chinese patent document CN111617030A disclosed chitosan oligosaccharides on September 4, 2020 Oral liquid and its application in the preparation of weight-loss drugs, the oral solution of oligochitosan is easily degraded by gastric acid, resulting in a decrease in the amount of oligochitosan acting on the intestinal flora and reducing the efficacy of the drug; Chinese patent document CN108653317A was published in October 2018 On the 16th, a chitosan oligosaccharide oral solution and its preparation method were disclosed. It was prepared from 25-40 parts of chitosan oligosaccharide, 1-3 parts of flavoring agent, 2-4 parts of preservative, and 1.5-2 parts of stabilizer. The addition of a large amount of excipients will lead to a decrease in the content of the main drug in the same volume, and it will also be easily degraded by the stomach

Method used

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  • Chitosan oligosaccharide enteric capsule as well as preparation method and application thereof
  • Chitosan oligosaccharide enteric capsule as well as preparation method and application thereof
  • Chitosan oligosaccharide enteric capsule as well as preparation method and application thereof

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Embodiment 1

[0026] Embodiment 1, chitosan oligosaccharide enteric-coated capsule of the present invention and its preparation

[0027] Recipe: Oligochitosan 10g, Eudragit L100 40g, HPMC10g, Drcaps capsule shell

[0028] making process:

[0029] S1. Dissolution: Dissolve Eudragit L100 in water and let it swell for 0.5 hours to obtain Eudragit L100 solution; dissolve HPMC in water and let it stand for 0.5 hours to obtain HPMC solution; completely dissolve chitosan oligosaccharide in water to obtain chitosan oligosaccharide solution ;

[0030] S2. Stirring: Slowly add the chitosan oligosaccharide solution into the Eudragit L100 solution while stirring, then add the HPMC solution, and stir vigorously with a magnetic stirrer for 0.5h to obtain a mixed medicinal solution;

[0031] S3. Ultrasonic treatment: put the mixed medicinal solution into an ultrasonic instrument, and perform ultrasonic treatment at the highest frequency for 0.5 h at 37°C;

[0032] S4. Freeze-drying: The ultrasonically ...

Embodiment 2

[0034] Embodiment 2, oligochitosaccharide enteric-coated capsule of the present invention and its preparation

[0035] Recipe: Chitooligosaccharide 20g, Eudragit L100 80g, HPMC 20g, Drcaps capsule shell

[0036] making process:

[0037] S1. Dissolution: Dissolve Eudragit L100 in water and let it swell for 0.5 hours to obtain Eudragit L100 solution; dissolve HPMC in water and let it stand for 0.5 hours to obtain HPMC solution; completely dissolve chitosan oligosaccharide in water to obtain chitosan oligosaccharide solution ;

[0038] S2. Stirring: Slowly add the chitosan oligosaccharide solution into the Eudragit L100 solution while stirring, then add the HPMC solution, and stir vigorously with a magnetic stirrer for 0.5h to obtain a mixed medicinal solution;

[0039] S3. Ultrasonic treatment: put the mixed drug into an ultrasonic instrument, and perform ultrasonic treatment at the highest frequency at 37°C for 0.5h;

[0040] S4. Freeze-drying: The ultrasonically treated mixed...

Embodiment 3

[0042] Embodiment 3, oligochitosaccharide enteric-coated capsule of the present invention and its preparation

[0043] Recipe: Chitooligosaccharide 30g, Eudragit L100 120g, HPMC 30g, Drcaps capsule shell

[0044] making process:

[0045] S1. Dissolution: Dissolve Eudragit L100 in water and let it swell for 0.5 hours to obtain Eudragit L100 solution; dissolve HPMC in water and let it stand for 0.5 hours to obtain HPMC solution; completely dissolve chitosan oligosaccharide in water to obtain chitosan oligosaccharide solution ;

[0046] S2. Stirring: Slowly add the chitosan oligosaccharide solution into the Eudragit L100 solution while stirring, then add the HPMC solution, and stir vigorously with a magnetic stirrer for 0.5h to obtain a mixed medicinal solution;

[0047] S3. Ultrasonic treatment: put the mixed medicinal solution into an ultrasonic instrument, and perform ultrasonic treatment at the highest frequency for 0.5 h at 37°C;

[0048] S4. Freeze-drying: The ultrasonic...

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Abstract

The invention discloses a chitosan oligosaccharide enteric capsule which comprises a content and a capsule shell, the content comprises an enteric auxiliary material, chitosan oligosaccharide and a release regulator, and the mass ratio of the enteric auxiliary material to the chitosan oligosaccharide to the release regulator is (3-5): 1: 1; the chitosan oligosaccharide enteric capsule content is prepared by a freeze drying method, compared with a traditional preparation process, the dosage of auxiliary materials can be reduced to a great extent, the process is reasonable and stable, the smell of chitosan oligosaccharide can be well covered, the patient compliance is improved, and the chitosan oligosaccharide enteric capsule content has the enteric preparation characteristics of being insoluble in the stomach and instant in the intestine; the smell of the chitosan oligosaccharide can be well covered, the compliance of a patient is improved, the degradation of the chitosan oligosaccharide in gastric acid can be reduced, and the release and absorption of a molecular prototype of the chitosan oligosaccharide in intestinal tracts can be increased.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a chitosan oligosaccharide enteric-coated capsule and a preparation method and application thereof. Background technique [0002] Obesity is a relatively complex chronic endocrine disease, the main cause and manifestation of which is excessive accumulation of body fat, which is closely related to metabolic diseases such as diabetes, non-alcoholic fatty liver, and hyperlipidemia. Adverse effects caused by obesity are mainly divided into two categories: one is symptoms caused by excessive accumulation of adipose tissue in the body (such as osteoarthritis, obstructive sleep apnea, stigma caused by physical appearance), and the other is caused by Diseases (T2DM, cardiovascular disease, non-alcoholic fatty liver disease) caused by excessive increase in the number of fat cells in other tissues and organs in the state of obesity. In addition, the strength of the ass...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/46A61K47/38A61K47/32A61K31/7016A61K31/702A61K31/722A61P3/04
CPCA61K9/1682A61K9/1635A61K9/1652A61K9/1664A61K31/7016A61K31/702A61K31/722A61P3/04Y02A50/30
Inventor 苏政权曹华白研贺锦灿
Owner GUANGDONG PHARMA UNIV
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