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A kind of active peptide microparticle preparation and preparation method thereof

A technology of active peptides and microparticles, applied in the direction of microcapsules, applications, capsule delivery, etc., to achieve the best dispersion effect

Active Publication Date: 2020-09-18
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the existing microcapsule technology processes cannot solve the above problems at the same time.

Method used

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  • A kind of active peptide microparticle preparation and preparation method thereof
  • A kind of active peptide microparticle preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: Preparation of the active peptide microparticle preparation of the present invention

[0029] Add sodium alginate (viscosity 300cp.s) into pure water, stir and dissolve to obtain an aqueous solution of sodium alginate; wherein the mass concentration of the aqueous solution of sodium alginate is 1.5%;

[0030] Add bonito peptide powder into the ammonium alginate aqueous solution and stir to obtain a mixed solution of bonito peptide and sodium alginate; wherein, the mass of sodium alginate and bonito peptide in the mixed solution of bonito peptide and sodium alginate The ratio is 1:2;

[0031] Adding calcium chloride, barium chloride and magnesium chloride in water as a crosslinking agent, stirring to obtain a crosslinking agent solution; wherein, the mass ratio of calcium chloride, barium chloride and magnesium chloride is 1.2:0.1:0.2;

[0032] Adjust the pH of the above-mentioned crosslinking agent solution to 4.5;

[0033] Add 100 mL of the mixed soluti...

Embodiment 2

[0036] Embodiment 2: Preparation of the active peptide microparticle preparation of the present invention

[0037] Add sodium alginate (viscosity 300cp.s) into pure water, stir and dissolve to obtain an aqueous solution of sodium alginate; wherein the mass concentration of the aqueous solution of sodium alginate is 1.5%;

[0038] Add bonito peptide powder into the ammonium alginate aqueous solution and stir to obtain a mixed solution of bonito peptide and sodium alginate; wherein, the mass of sodium alginate and bonito peptide in the mixed solution of bonito peptide and sodium alginate The ratio is 1:1;

[0039]Adding calcium chloride, barium chloride and magnesium chloride in water as a crosslinking agent and stirring to obtain a crosslinking agent solution; wherein the mass ratio of calcium chloride, barium chloride and magnesium chloride is 1.0:0.2:0.3;

[0040] Adjust the pH of the above-mentioned crosslinking agent solution to 4.5;

[0041] Add 100 mL of the mixed solut...

Embodiment 3

[0043] Embodiment 3: preparation active peptide microparticle preparation of the present invention

[0044] Add sodium alginate (viscosity 300cp.s) into pure water, stir and dissolve to obtain an aqueous solution of sodium alginate; wherein the mass concentration of the aqueous solution of sodium alginate is 1.5%;

[0045] Add bonito peptide powder into the ammonium alginate aqueous solution and stir to obtain a mixed solution of bonito peptide and sodium alginate; wherein, the mass of sodium alginate and bonito peptide in the mixed solution of bonito peptide and sodium alginate The ratio is 1:2;

[0046] Chitosan (molecular weight 150kDa) is added in the acetic acid aqueous solution of 1% mass concentration, stirs and dissolves, obtains the acetic acid aqueous solution of chitosan; Wherein the mass concentration of chitosan is 1%;

[0047] Add calcium chloride, barium chloride and magnesium chloride in the acetic acid aqueous solution of above-mentioned chitosan, stir, obtai...

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Abstract

The invention relates to the field of microcapsules and discloses an active peptide microparticle preparation and a preparation method thereof. The preparation method comprises the following steps: adding active peptides in a sodium alginate solution to obtain an active peptide and sodium alginate mixed solution, then dropwise adding into a chitosan and cross-linking agent mixed solution or a cross-linking agent solution through a microcapsule granulator to obtain active peptide microparticles and freeze-drying to obtain the active peptide microparticle preparation; a cross-linking agent is a combination of calcium chloride, barium chloride and magnesium chloride. The active peptide microparticle preparation and the preparation method thereof provided by the invention have the benefits that through the proper cross-linking agent and the proportion thereof, the active peptide microparticle preparation has better dispersity when being brewed with water with higher temperature, meanwhile better masks the odor of the active peptides and effectively solves the problems of influence of the active peptides on long-term use of a consumer and mouth feeling.

Description

technical field [0001] The invention relates to the technical field of microcapsules, in particular to an active peptide microparticle preparation and a preparation method thereof. Background technique [0002] Many active peptides extracted from automatic plants, such as oyster peptides, skipjack fish peptides, and sea cucumber peptides, have strong biological activity and are ideal functional factors for health food. However, these active peptides have a strong odor that consumers cannot bear, which seriously affects the customer experience and willingness to take it for a long time. Therefore, there is an urgent need to improve the mouthfeel of these active peptides through taste-masking technology. [0003] Adding excipients relieves bitterness by interfering with the taste buds. The method is the simplest and the cost is low, but the effect is limited, and the effect is not good for extremely bitter and easily hydrolyzed drugs. Moreover, due to differences in taste pr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A23P10/30A23L33/18
Inventor 陈伟鸿肖俊勇马方励盛剑勇马忠华
Owner INFINITUS (CHINA) CO LTD
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