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Application of saussurea japonica in preparation of medicine for preventing and treating diseases characterized by fever caused by microbial infection

A technique for microbial infection, zebrasia, applied in the field of medicine

Pending Publication Date: 2022-04-08
INNER MONGOLIA UNIV FOR THE NATITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to relevant literature reports at home and abroad, the current research on Pseudomonas praecox is limited to the detection of amino acid components, research on active ingredients related to bile salt-independent stimulation of bile secretion, etc.

Method used

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  • Application of saussurea japonica in preparation of medicine for preventing and treating diseases characterized by fever caused by microbial infection
  • Application of saussurea japonica in preparation of medicine for preventing and treating diseases characterized by fever caused by microbial infection
  • Application of saussurea japonica in preparation of medicine for preventing and treating diseases characterized by fever caused by microbial infection

Examples

Experimental program
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preparation example Construction

[0022] In the present invention, there is no special limitation on the preparation method of the extract of Zebrasia meadowsii, and the extraction methods known to those skilled in the art will suffice.

[0023] In the present invention, the preparation method of the medicinal material powder of the prairie chrysanthemum includes: after the medicinal material of the prairie chrysanthemum is dried, it is directly pulverized, and passed through a 60-mesh sieve to obtain the product;

[0024] The preparation method of the ethanol extract of C. meadowsii comprises: mixing C. meadowskin with ethanol aqueous solution or absolute ethanol with a volume concentration of 70% and 95%, soaking, extracting by heating under reflux, and filtering to obtain the product.

[0025] Wherein, the mass-to-volume ratio of Cauliflower prairie and ethanol aqueous solution or absolute ethanol of the present invention is preferably 1g: (9~10) ml; more preferably 1g: 10ml; the temperature of the soaking i...

Embodiment 1

[0064] Embodiment 1: the preparation method of the extracts of all levels of Rhizoma praecox

[0065] (1) Alcoholic Extract of Saffron

[0066] Take 500g of Cauliflower, add 10 times the amount of 95% ethanol (5000mL) to soak for 4-6 hours, heat and reflux for extraction for 4 hours, extract 3 times, and combine the extracts. After filtering with 4 layers of gauze, the filtrate was recovered with a rotary evaporator to recover the solvent under reduced pressure. After recovering 95% ethanol, it was dried in the air to obtain the 95% ethanol extract of C.

[0067] (2) Water extract of prairie chrysanthemum

[0068] Take 500g of prairie chrysanthemum, add 10 times the amount of water (5000mL) to soak for 4-6 hours, heat and reflux for extraction for 4 hours, extract 3 times, and combine the extracts. After filtering with 4 layers of gauze, the filtrate is recovered with a rotary evaporator under reduced pressure to recover the solvent, and after the recovery of water is comple...

Embodiment 2

[0087] Example 2: Antipyretic effect and mechanism of Rhizoma praecox medicinal powder, water extract of Rhizoma praecox and ethanol extract of Rhizoma praecox on dry yeast-induced fever rats

[0088] SD rats with a body weight of about 220-240 g were selected. Three days before the experiment, the rectal temperature was measured twice a day with a thermometer at intervals of 1 hour, so that they could adapt to the operation of rectal temperature measurement in subsequent experiments and reduce the influence of temperature fluctuations in subsequent experiments on the experimental results. Rats whose rectal temperature exceeded 38°C twice at intervals in the first 3 days or whose difference was greater than 0.5°C between the two measurements were excluded. The remaining rats were randomly divided into the blank control group, the model control group, the aspirin group (positive), the prairie chamomile medicinal material powder group, and the high, medium, and low dose groups of...

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Abstract

The invention provides an application of saussurea meadow in preparation of a medicine for preventing and treating diseases characterized by fever caused by microbial infection. The invention discloses a new application of a saussurea meadow medicinal material and an extract thereof in preparation of antipyretic and anti-inflammatory drugs. The saussurea meadow medicinal material and the extract thereof have antipyretic and anti-inflammatory effects in cellular level, molecular level and animal experiments.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to the application of a prairie chrysanthemum in the preparation of medicines for preventing and treating diseases characterized by fever caused by microbial infection. Background technique [0002] Fever is one of the common clinical symptoms, a conservative systemic response triggered by infectious or non-infectious diseases, and one of the early indications of infection, inflammation and poisoning. As an important pathological process and clinical manifestation of many diseases, fever is also an important signal of disease occurrence, which affects a complex process of multiple systems of endocrine, nervous, immune and behavioral systems in the central nervous system. [0003] Modern medicine believes that fever is caused by exogenous pyrogens such as various microorganisms, pathogens and their products, inflammatory exudates, sterile necrotic tissue, antigen-antibo...

Claims

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Application Information

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IPC IPC(8): A61K36/285A61P31/16A61P1/00A61P31/10A61P29/00
Inventor 辛颖红艳青云郝俊生喜杰
Owner INNER MONGOLIA UNIV FOR THE NATITIES
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