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Gradient degradation skin filler and preparation method thereof

A dermal filler and gradient technology, which is applied in the field of gradient degradable dermal fillers and their preparation, can solve the problems of inability to achieve filling effects, slow degradation of fillers and ease of operation, and high hardness of products, so as to prevent immunity Risk of origin and risk of endotoxin, no risk of allergy, effect of excellent rheological properties

Active Publication Date: 2022-03-15
西安德诺海思医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the addition of microspheres itself will cause changes in the rheological properties of the filler. If the cross-linking of the gel component is too high, the overall product will be harder and difficult to inject; while the cross-linking of the gel component is too low, the degradation will still be relatively low. Fast, unable to achieve a more natural filling effect, so the current cross-linking process cannot meet the perfect combination of slow degradation of fillers and ease of operation
[0005]In addition, collagen and sodium hyaluronate are both derived from animal tissue extraction or microbial fermentation, and there are risks of immunogenicity and endotoxin contamination

Method used

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  • Gradient degradation skin filler and preparation method thereof
  • Gradient degradation skin filler and preparation method thereof
  • Gradient degradation skin filler and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] This embodiment provides a preparation method of a gradient degradable dermal filler, comprising the following steps:

[0047] 1. Preparation of gel phase:

[0048] 1.1 Sodium polyglutamate is prepared into a sodium polyglutamate solution with a concentration of 25%, and carbodiimide with a concentration of 1% is added to the sodium polyglutamate solution, and then the solution is placed at room temperature for cross-linking 24 hours, after the cross-linking is completed, dialyze the gel block for 24 hours to remove the cross-linking agent. The diameter range is between 25-200μm;

[0049] 1.2 Prepare a sodium polyglutamate solution with a concentration of 8%, add 0.2% carbodiimide at 2-8°C, and add the above-mentioned primary cross-linked sodium polyglutamate gel particles to the 8% sodium polyglutamate solution , stir to make the carbodiimide and sodium polyglutamate solution evenly adhere to the primary cross-linked sodium polyglutamate gel particles, then separate,...

Embodiment 2

[0055] This embodiment provides a preparation method of a gradient degradable dermal filler, comprising the following steps:

[0056] 1. Preparation of gel phase:

[0057] 1.1 Prepare sodium alginate into a sodium alginate solution with a concentration of 10%, add polyethylene glycol diglycidyl ether with a final concentration of 8% to the sodium alginate solution, and then place the solution at 60°C for cross-linking After 2.5 hours, after the cross-linking is completed, the gel block is broken into 0.3-0.5mm particles, boiled in water for 10 minutes, and repeated 3 times after changing the water, and the obtained gel is screened to obtain a cross-linked sodium alginate gel. Colloidal particles, so that the particle size range is between 25-200 μm;

[0058] 1.2 Prepare a sodium alginate solution with a concentration of 2%, add 0.6% polyethylene glycol diglycidyl ether at 2-8°C, add the above-mentioned primary cross-linked sodium alginate gel particles into the 2% sodium algi...

Embodiment 3

[0064] This embodiment provides a preparation method of a gradient degradable dermal filler, comprising the following steps:

[0065] 1. Preparation of gel phase:

[0066] 1.1 Sodium carboxymethyl cellulose is formulated into a sodium carboxymethyl cellulose solution with a concentration of 5%, and epichlorohydrin with a final concentration of 2% is added to the sodium carboxymethyl cellulose solution, and then the solution is placed at 50 Cross-linking at ℃ for 6 hours. After cross-linking, wash the gel blocks alternately with absolute ethanol / water for 30 minutes each time. One hour is a cleaning cycle. Washing for 4 cycles, the resulting gel is placed in A vacuum drying oven volatilizes the absolute ethanol therein, and passes through a sieve to obtain primary croscarmellose sodium gel particles, so that the particle size range is between 25-200 μm;

[0067] 1.2 Separately prepare a 1% sodium carboxymethylcellulose solution, add 0.8% epichlorohydrin at 2-8°C, add 1% carbox...

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Abstract

The invention discloses a gradient degradation skin filler and a preparation method thereof, and relates to the field of tissue filling and medical biological materials. In the filling agent disclosed by the invention, a gel matrix phase serving as a carrier is subjected to secondary crosslinking, so that primary crosslinking gel particles with relatively high crosslinking degree can be uniformly dispersed in a matrix material with relatively low crosslinking degree, and a gel particle matrix formed by the filling agent is high in central crosslinking degree and low in peripheral crosslinking degree; in addition, by compounding degradable or non-degradable microspheres, self collagen regeneration is stimulated. The filler prepared by the secondary crosslinking process has excellent rheological mechanical properties, not only has deformation resistance and durability endowed by high-crosslinking-degree gel, but also has softness and natural aesthetics brought by low-crosslinking-degree gel.

Description

technical field [0001] The invention relates to the fields of tissue filling and medical biomaterials, in particular to a gradient degradable dermal filler and a preparation method thereof. Background technique [0002] Affected by many factors, the face will gradually show aging changes. Years of sun exposure is the single biggest contributor to aging changes in the skin, and it also plays a role in many other facial cosmetic concerns. Usually with age, the fat, collagen and hyaluronic acid in the skin will gradually decrease, and the face will gradually lose its plump and youthful appearance, resulting in wrinkles of varying degrees. With years of facial expression and repeated skin folding, dynamic wrinkles gradually form, such as the forehead, glabella, nasolabial folds, perioral and periorbital areas; facial tissues gradually lose their own elasticity and ability to resist tension, and under the action of gravity A saggy look inevitably begins to develop underneath. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/18A61L27/12A61L27/16A61L27/50A61L27/52A61L27/58
CPCA61L27/20A61L27/18A61L27/16A61L27/12A61L27/52A61L27/58A61L27/50A61L2430/34A61L2400/06
Inventor 张立娟
Owner 西安德诺海思医疗科技有限公司
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