Intestinal flora marker for predicting curative effect of immunotherapy and application of intestinal flora marker
A technology of intestinal flora and immunotherapy, applied in the field of immunotherapy, can solve the problems of analyzing species and difficult bacteria, achieve the effect of large individual differences, multiple detection targets, and avoid the disadvantages of single index detection
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[0085] According to the current research results, a single detection index is difficult to effectively predict the efficacy of immunotherapy, and there is a high false positive or false negative rate. As a biomarker, intestinal flora has the advantages of large individual differences and multiple detection targets. Based on the detection method of real-time fluorescence quantitative PCR, the present invention screens 55 detection targets of intestinal bacterial genome DNA, and obtains 5 scoring formulas that can be used to predict the curative effect of immunotherapy. The relative expression level and scoring of targets can predict the efficacy of immunotherapy in melanoma patients with different drug regimens. The specific detection targets and their numbers are as follows:
[0086]
[0087] Due to the particularity of stool samples, the amount of samples collected or added cannot reach the same degree of standardization as that of blood and urine samples, so it is diffic...
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