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Application of magnesium salviae miltiorrhizae acetate in preparation of anti-pulmonary fibrosis medicine

A technology of magnesium acetate of salvia miltiorrhiza and pulmonary fibrosis, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., and can solve the problem of little therapeutic effect on pulmonary fibrosis

Pending Publication Date: 2022-02-25
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, due to insufficient understanding of the pathological changes and pathogenesis of pulmonary fibrosis in previous studies, it was believed that the anti-fibrosis effect of salvianolic acid B was mainly due to its anti-inflammatory activity, and dexamethasone was selected as the positive control. Pulmonary Fibrosis Treatments Have Little Response

Method used

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  • Application of magnesium salviae miltiorrhizae acetate in preparation of anti-pulmonary fibrosis medicine
  • Application of magnesium salviae miltiorrhizae acetate in preparation of anti-pulmonary fibrosis medicine
  • Application of magnesium salviae miltiorrhizae acetate in preparation of anti-pulmonary fibrosis medicine

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Experimental program
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Embodiment

[0023] Experimental reagents: 75% alcohol, absolute ethanol were purchased from Sinopharm Chemical Reagent Co., Ltd.; DMSO was purchased from Sigma-Aldrich Company; penicillin and streptomycin, fetal bovine serum (FBS), 10×PBS were purchased from Gibco Company; MEM medium , F-12K medium was purchased from Hyclone Company; Trizol was purchased from Thremo life science; bleomycin (BLM) and pirfenidone (Pirfenidone) were purchased from Dalian Meilun Biotechnology Co., Ltd.; Prepared by CN104974119B; CCK8 kit, SYBR Green fluorescent dye purchased from Shanghai Yisheng Biotechnology Co., Ltd.; reverse transcriptase provided by Takara.

[0024] Surgical instruments: ophthalmic scissors, ophthalmic forceps, 1ml syringe, among which scissors and forceps need to be sterilized and dried in advance.

[0025] Experimental equipment: low-temperature high-speed centrifuge (Eppendorf, 5415R), cell incubator (Thermo Fisher Scientific, 371), ultrapure water preparation system (Pall Cascada), u...

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Abstract

The invention provides an application of magnesium salviae miltiorrhizae acetate in preparation of an anti-pulmonary fibrosis medicine. Compared with the prior art, the MLB can show the same anti-fibrosis curative effect as pirfenidone which is clinically used at present, on one hand, the MLB can relieve the pulmonary fibrosis symptom of a mouse and relieve lung tissue damage and collagen deposition, and thus the survival rate of the mouse is improved; and on the other hand, the compound also shows an inhibition effect on in-vitro fibrotic cells, and has no obvious cytotoxicity at the cellular level.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to the use of magnesium salvia acetate in the preparation of anti-pulmonary fibrosis drugs. Background technique [0002] The lung is one of the most important organs that undertake the basic functions of human life such as respiration and blood circulation. The lung also has certain secretion and metabolism functions. Pulmonary fibrosis is a serious irreversible and fatal lung disease, which is the second leading cause of death in patients with lung diseases after cancer. The cause of pulmonary fibrosis is unknown, and it often occurs in the elderly. Since the last century, the incidence of the disease has been slowly increasing year by year. In recent years, it has also been reported in young people. The prognosis of patients with pulmonary fibrosis is extremely poor, and the survival time after diagnosis is generally less than three years. [0003] At present, the drug thera...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/343A61P11/00
CPCA61K31/343A61P11/00
Inventor 宣利江潘国宇罗鑫王文琼
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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