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Annona cherimolia and purslane herb compound as well as preparation method and application thereof

A compound, purslane technology, applied in the directions of pharmaceutical formulations, cosmetic preparations, cosmetic preparations, etc., can solve the problems of reduced activity, low efficacy, low yield, etc., so as to soothe skin, reduce activity, and improve pain. Effect

Pending Publication Date: 2022-02-18
杭州配方师科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, the extracts of cherimoya such as cyclic peptides and the extracts of purslane such as Omega-3,6 are obtained by water extraction, and this extraction method will make the cyclic peptides and Omega-3,6 The rate is relatively low. Adding cyclic peptides and Omega-3,6 directly to the raw materials of skin care products will have the problem of low efficacy, mainly reflected in the poor effect of cyclic peptides and Omega-3,6 on the activity reduction of TRPV1 and NF-κB The soothing effect on the skin is also relatively poor

Method used

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  • Annona cherimolia and purslane herb compound as well as preparation method and application thereof
  • Annona cherimolia and purslane herb compound as well as preparation method and application thereof
  • Annona cherimolia and purslane herb compound as well as preparation method and application thereof

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preparation example Construction

[0028] The present invention also provides a preparation method of the compound of cherimoya and purslane, which is characterized in that: comprising the following steps:

[0029] S01 raw material processing: mixing cherimoya peel and purslane, drying and pulverizing;

[0030] S02 extraction: Add the pulverized raw material into the mixed solution of polyol / water, inject it into the extraction device, and add supercritical carbon dioxide solvent into the extraction device for extraction, and obtain the extract containing cyclic peptide and Omega-3,6 fatty acid ;

[0031] S03 catalysis: add lipase to the extract to catalyze for a period of time, and obtain the cyclic peptide fatty acid complex after centrifugal filtration.

[0032] Polyols are 1,2-butanediol, 1,2-hexanediol, 1,2-pentanediol, 1,3-propanediol, 1,5-pentanediol, butanediol, propylene glycol, hexanediol , 1,6-hexanediol, 2,3-butanediol or one or more.

[0033] The mixed solution is formed by mixing polyhydric alc...

Embodiment 1

[0042] A preparation method of cherimoya and purslane compound, is characterized in that: comprises the following steps:

[0043] S01 Raw material processing: Select clean and complete cherimoya peel and purslane, mix the cherimoya peel and purslane into the tank, place the tank to dry at 100°C, and then put the of cherimoya peel and purslane crushed;

[0044]S02 extraction: take 1kg of pulverized raw material powder and add it to 5kg of mixed solution, mix it and pour it into the extraction tank, and add supercritical carbon dioxide solvent into the extraction tank for extraction to obtain cyclic peptides and Omega-3,6 fatty acids The extraction solution, wherein the mixed solution is mixed with 1,2-butanediol and water at a mass ratio of 1:1, the temperature in the extraction cylinder is 45°C during extraction, and the flow rate of supercritical carbon dioxide solvent is 35L / h. The extraction time is 0.5h;

[0045] S03 catalysis: add Rhizopus lipase to the extract, catalyz...

Embodiment 2

[0048] A preparation method of cherimoya and purslane compound, is characterized in that: comprises the following steps:

[0049] S01 Raw material processing: Select clean and complete cherimoya peel and purslane, mix the cherimoya peel and purslane into the tank, place the tank at 60°C to dry, and then put the of cherimoya peel and purslane crushed;

[0050] S02 extraction: Take 1kg of pulverized raw material powder and add it to 1kg of mixed solution, inject it into the extraction tank after mixing, and add supercritical carbon dioxide solvent into the extraction tank for extraction to obtain cyclic peptides and Omega-3,6 fatty acids The extraction solution, wherein the mixed solution is made of 1,2-hexanediol and water at a mass ratio of 1:2, the temperature in the extraction cylinder is 30°C during extraction, and the flow rate of supercritical carbon dioxide solvent is 20L / h. The extraction time is 3h;

[0051] S03 Catalysis: Add Psychrobacter lipase to the extract, cat...

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Abstract

The invention discloses anAnnona cherimolia and purslane herb compound and a preparation method and application thereof. The compound is a cyclopeptide fatty acid compound generated by reaction of cyclopeptide contained in Annona cherimolia and Omega-3,6 fatty acid contained in purslane herb, and the compound is prepared through the steps of drying, smashing, supercritical carbon dioxide solvent extraction and lipase catalysis. According to the application of the cyclopeptide fatty acid compound as a raw material of a skin care product, the yield of the cyclopeptide and the Omega-3,6 can be improved through the preparation method, the cyclopeptide and the Omega-3,6 are catalyzed through biological catalysis to generate the cyclopeptide fatty acid compound, and the cyclopeptide fatty acid compound effectively reduces the activity of TRPV1 and NF-[kappa]B and plays a role in relieving the skin.

Description

【Technical field】 [0001] The invention belongs to the technical field of plant extraction, and in particular relates to a compound of cherimoya and purslane and its preparation method and application. 【Background technique】 [0002] Anemone is a deciduous small tree of the family Annonaceae, which can be cultivated in southern Yunnan, China, and Hainan Island, Guangdong. The edible fruit is a famous tropical fruit, containing 1.83% protein, 0.14% fat and 18.41% sugar. The rind of custard apple contains many biologically significant natural compounds, such as alkaloids (mainly isoquinolines), annonaceae lactones, cyclic peptides, and dimeramides. Among them, cyclic peptides are an important class of natural product compounds. Drugs such as vancomycin, cyclosporine, daptomycin, glamimycin S and bleomycin belong to this class. Their success in the market proves that these Types of molecules can range from antibiotic and antifungal compounds to immunosuppressants and even anti...

Claims

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Application Information

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IPC IPC(8): C07K7/06C12P21/02A61K8/64A61Q19/00
CPCC07K7/06C12P21/02A61K8/645A61Q19/00Y02P20/54
Inventor 陈旻庞颖潘莎
Owner 杭州配方师科技有限公司
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