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Preparation method of traditional Chinese medicine molecule doped polypyrrole nanoparticles

A technology of polypyrrole nanometer and polyvinylpyrrolidone, which is applied in the field of preparation of polypyrrole nanoparticle, can solve the problems of difficult control and preparation, achieve long-term inhibition of remaining tumor activity, simple preparation process, and low cost

Pending Publication Date: 2022-02-18
CHINA-SINGAPORE INT JOINT RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, the photothermal effect of pure polypyrrole needs auxiliary agents to improve, and there are various types of auxiliary agents, which are difficult to control and prepare

Method used

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  • Preparation method of traditional Chinese medicine molecule doped polypyrrole nanoparticles
  • Preparation method of traditional Chinese medicine molecule doped polypyrrole nanoparticles
  • Preparation method of traditional Chinese medicine molecule doped polypyrrole nanoparticles

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Experimental program
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Embodiment 1

[0029] This embodiment provides a preparation method of polypyrrole nanoparticles doped with traditional Chinese medicine molecules, comprising the following steps:

[0030] S1. Add 1g of polyvinylpyrrolidone (PVP) and 25ml of ultrapure water into a 50ml round bottom flask, stir for 0.5h at room temperature, and mark it as No. 1;

[0031] Add 0.0907g dopamine after the stirring is completed;

[0032] Add 0.25ml of the prepared ginsenoside Rh1 aqueous solution (40mg / ml);

[0033] S2. Add 130 μL of pyrrole monomer to the solution prepared in step S1, and continue stirring to fully dissolve it;

[0034] S3, add 1ml ferric chloride hexahydrate solution (0.75g / ml) to the solution prepared in step S2, stir for 3h, seal three circles of sealing paper at the bottle mouth, prevent air interference, fully react;

[0035] S4. Centrifuge at a speed of 12000r / min for 30 minutes to fully precipitate. After the reaction is complete, wash with a large amount of ethanol / acetone mixture, and ...

Embodiment 2

[0037] This embodiment provides a preparation method of polypyrrole nanoparticles doped with traditional Chinese medicine molecules, comprising the following steps:

[0038] S1. Add 0.2g polyvinylpyrrolidone (PVP) and 25ml ultrapure water into a 50ml round bottom flask, stir for 0.5h at room temperature, and mark it as No. 1;

[0039] Add 0.3g of dopamine after the stirring is completed;

[0040] Add 0.25ml of the prepared ginsenoside Rh1 aqueous solution (8mg / ml);

[0041] S2. Add 70 μL of pyrrole monomer to the solution prepared in step S1, and continue stirring to fully dissolve it;

[0042] After S3, 10min, add 1ml ferric chloride hexahydrate solution (0.2g / ml) to the solution prepared in step S2, stir for 3h, seal three circles of sealing paper at the bottle mouth, prevent air interference, and fully react;

[0043] S4. Centrifuge at a speed of 12000r / min for 30 minutes to fully precipitate. After the reaction is complete, wash with a large amount of ethanol / acetone mix...

Embodiment 3

[0045] This embodiment provides a preparation method of polypyrrole nanoparticles doped with traditional Chinese medicine molecules, comprising the following steps:

[0046] S1. Add 2g of polyvinylpyrrolidone (PVP) and 25ml of ultrapure water into a 50ml round bottom flask, stir for 0.5h at room temperature, and mark it as No. 1;

[0047] Add 0.0241g dopamine after the stirring is completed;

[0048] Add 0.25ml of prepared ginsenoside Rh1 aqueous solution (80mg / ml);

[0049] S2. Add 570 μL of pyrrole monomer to the solution prepared in step S1, and continue stirring to fully dissolve it;

[0050] After S3, 10min, add 1ml ferric chloride hexahydrate solution (2.50g / ml) to the solution prepared in step S2, stir for 3h, seal three circles of sealing paper at the bottle mouth, prevent air interference, fully react;

[0051] S4. Centrifuge at a speed of 12000r / min for 30 minutes to fully precipitate. After the reaction is complete, wash with a large amount of ethanol / acetone mixt...

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Abstract

The invention discloses a preparation method of traditional Chinese medicine molecule doped polypyrrole nanoparticles. The preparation method comprises the following steps: S1, sequentially dissolving polyvinylpyrrolidone, dopamine and ginsenoside Rh1; S2, adding a pyrrole monomer into the solution in the step S1, and conducting stirring to fully dissolve the pyrrole monomer; S3, adding a ferric chloride hexahydrate solution into the solution in the step S2, fully conducting stirring and mixing, conducting sealing, and conducting stirring for reacting for a period of time; and S4, after the reaction is completed, performing high-speed centrifugation, and performing cleaning with an ethanol / acetone mixed solution to finally obtain the nanoparticles. Conductive polypyrrole is used as a main body, traditional Chinese medicine molecules and polydopamine are jointly used as doping agents, and the nano-particles with photo-thermal rapid and long-acting anti-tumor functions are constructed.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a preparation method of polypyrrole nanoparticles doped with traditional Chinese medicine molecules. Background technique [0002] In recent years, in terms of tumor research, photothermal therapy of polypyrrole is gradually emerging. Compared with traditional chemotherapy and surgical resection, the high efficiency and low toxicity of photothermal therapy have become its huge competitive advantages. Photothermal therapy uses materials with strong light absorption in the near infrared to convert light energy into heat energy to kill cancer cells. Compared with traditional chemotherapy and radiotherapy, it has the advantages of less side effects and better specificity. In recent years, various nanomaterials have been used in tumor photothermal therapy, and excellent therapeutic effects have been achieved in animal tumor model experiments. Polypyrrole (PPy) is an orga...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K31/704A61K9/52A61K47/34A61P35/00B82Y5/00B82Y40/00
CPCA61K41/0052A61K31/704A61K9/5146A61K9/5192A61P35/00B82Y5/00B82Y40/00A61K2300/00
Inventor 钱磊宁成云
Owner CHINA-SINGAPORE INT JOINT RES INST
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